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  • Eiji Oki
2015

Hyperthermia combined with chemotherapy for patients with residual or recurrent oesophageal cancer after definitive chemoradiotherapy

Maehara, Y., Nishimura, S., Saeki, H., Nakanoko, T., Kasagi, Y., Tsuda, Y., Zaitsu, Y., Ando, K., Nakashima, Y., Imamura, Y. U., Ohgaki, K., Oki, E., Ohga, S., Nakamura, K. & Morita, M., Apr 1 2015, In : Anticancer research. 35, 4, p. 2299-2304 6 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Indocyanine Green Fluorescence Angiography for Quantitative Evaluation of Gastric Tube Perfusion in Patients Undergoing Esophagectomy

Yukaya, T., Saeki, H., Kasagi, Y., Nakashima, Y., Ando, K., Imamura, Y., Ohgaki, K., Oki, E., Morita, M. & Maehara, Y., Aug 1 2015, In : Journal of the American College of Surgeons. 221, 2, p. e37-e42

Research output: Contribution to journalArticle

27 Citations (Scopus)

Intensive immunofluorescence staining methods for low expression protein: Detection of intestinal stem cell marker LGR5

Yamazaki, M., Kato, A., Zaitsu, Y., Watanabe, T., Iimori, M., Funahashi, S., Kitao, H., Saeki, H., Oki, E. & Suzuki, M., Oct 29 2015, In : Acta Histochemica et Cytochemica. 48, 5, p. 159-164 6 p.

Research output: Contribution to journalComment/debate

4 Citations (Scopus)

Intensive Immunofluorescence Staining Methods for Low Expression Protein: Detection of Intestinal Stem Cell Marker LGR5

Yamazaki, M., Kato, A., Zaitsu, Y., Watanabe, T., Iimori, M., Funahashi, S., Kitao, H., Saeki, H., Oki, E. & Suzuki, M., Oct 29 2015, In : Acta Histochemica et Cytochemica. 48, 5, p. 159-64 6 p.

Research output: Contribution to journalArticle

Laparoscopic total gastrectomy for RGC: Four case reports

Korehisa, S., Ohgaki, K., Yukaya, T., Zaitu, Y., Tsuda, Y., Kasagi, Y., Ando, K., Nakashima, Y., Imamura, Y., Saeki, H., Oki, E. & Maehara, Y., Sep 1 2015, In : Anticancer research. 35, 9, p. 5023-5026 4 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Long-term treatment with panitumumab monotherapy for recurrent colorectal cancer

Ando, K., Oki, E., Saeki, H., Nakashima, Y. & Maehara, Y., Jul 2015, In : International Cancer Conference Journal. 4, 3, p. 151 154 p.

Research output: Contribution to journalArticle

Loss of heterozygosity of PTEN (Encoding phosphate and tensin homolog) associated with elevated HER2 expression is an adverse prognostic indicator in gastric cancer

Zaitsu, Y., Oki, E., Ando, K., Ida, S., Kimura, Y., Saeki, H., Morita, M., Hirahashi, M., Oda, Y. & Maehara, Y., Mar 6 2015, In : Oncology (Switzerland). 88, 3, p. 189-194 6 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Molecular Characteristics of Basaloid Squamous Cell Carcinoma of the Esophagus: Analysis of KRAS, BRAF, and PIK3CA Mutations and LINE-1 Methylation

Baba, Y., Ishimoto, T., Harada, K., Kosumi, K., Murata, A., Miyake, K., Hiyoshi, Y., Kurashige, J., Iwatsuki, M., Iwagami, S., Miyamoto, Y., Sakamoto, Y., Yoshida, N., Oki, E., Iyama, K. I., Watanabe, M. & Baba, H., Oct 15 2015, In : Annals of Surgical Oncology. 22, 11, p. 3659-3665 7 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Molecular characteristics of colorectal neuroendocrine carcinoma; Similarities with adenocarcinoma rather than neuroendocrine tumor

Takizawa, N., Ohishi, Y., Hirahashi, M., Takahashi, S., Nakamura, K., Tanaka, M., Oki, E., Takayanagi, R. & Oda, Y., Dec 2015, In : Human Pathology. 46, 12, p. 1890-1900 11 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Number of lymph node metastases may indicate the regimen for adjuvant chemotherapy in patients with stage III colorectal cancer

Ando, K., Oki, E., Saeki, H., Kasagi, Y., Tsuda, Y., Zaitsu, Y., Nakashima, Y., Imamura, Y., Ohgaki, K. & Maehara, Y., Nov 2015, In : Anticancer research. 35, 11, p. 6207-6211 5 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

One-stage Procedure for Concomitant Abdominal Aortic Aneurysm and Gastric Cancer

Matsumoto, T., Matsuda, D., Honma, K., Aoyagi, Y., Okadome, J., Morisaki, K., Tanaka, S., Saeki, H., Oki, E. & Maehara, Y., Dec 1 2015, In : Anticancer research. 35, 12, p. 6909-6912 4 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Pharyngo-laryngo-esophagectomy and reconstruction with a gastric tube for corrosive pharyngoesophagitis

Kawano, H., Morita, M., Otsu, H., Ando, K., Hiyoshi, Y., Ito, S., Saeki, H., Oki, E. & Maehara, Y., Oct 1 2015, In : Esophagus. 12, 4, p. 360-364 5 p.

Research output: Contribution to journalArticle

Phase II Trial of S-1 and Oxaliplatin Plus Cetuximab for Colorectal Cancer Patients with Initially Unresectable or Not Optimally Resectable Liver Metastases (KSCC1002)

Oki, E., Emi, Y., Miyamoto, Y., Kabashima, A., Higashi, H., Ogata, Y., Ikebe, M., Saeki, H., Tokunaga, S., Shirabe, K., Beppu, T., Uchida, S., Takatsuki, M., Sakoda, M., Eguchi, S., Akagi, Y., Kakeji, Y., Baba, H., Natsugoe, S. & Maehara, Y., Dec 1 2015, In : Annals of Surgical Oncology. 22, p. 1067-1074 8 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Preventive effect of Goshajinkigan on peripheral neurotoxicity of FOLFOX therapy (GENIUS trial): a placebo-controlled, double-blind, randomized phase III study

Oki, E., Emi, Y., Kojima, H., Higashijima, J., Kato, T., Miyake, Y., Kon, M., Ogata, Y., Takahashi, K., Ishida, H., Saeki, H., Sakaguchi, Y., Yamanaka, T., Kono, T., Tomita, N., Baba, H., Shirabe, K., Kakeji, Y. & Maehara, Y., Aug 8 2015, In : International Journal of Clinical Oncology. 20, 4, p. 767-775 9 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Prognostic impact of Des-γ-carboxyl prothrombin in living-donor liver transplantation for recurrent hepatocellular carcinoma

Harimoto, N., Yoshida, Y., Kurihara, T., Takeishi, K., Itoh, S., Harada, N., Tsujita, E., Yamashita, Y. I., Uchiyama, H., Soejima, Y., Ikegami, T., Yoshizumi, T., Kawanaka, H., Ikeda, T., Shirabe, K., Saeki, H., Oki, E., Kimura, Y. & Maehara, Y., Apr 1 2015, In : Transplantation Proceedings. 47, 3, p. 703-704 2 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Prognostic nutritional index predicts severe complications, recurrence, and poor prognosis in patients with colorectal cancer undergoing primary tumor resection

Tokunaga, R., Sakamoto, Y., Nakagawa, S., Miyamoto, Y., Yoshida, N., Oki, E., Watanabe, M. & Baba, H., Nov 1 2015, In : Diseases of the colon and rectum. 58, 11, p. 1048-1057 10 p.

Research output: Contribution to journalArticle

102 Citations (Scopus)

Recent advances in multidisciplinary approach for rectal cancer

Oki, E., Ando, K., Kasagi, Y., Zaitsu, Y., Sugiyama, M., Nakashima, Y., Sonoda, H., Ohgaki, K., Saeki, H. & Maehara, Y., Aug 8 2015, In : International Journal of Clinical Oncology. 20, 4, p. 641-649 9 p.

Research output: Contribution to journalReview article

2 Citations (Scopus)

SPINK1 status in colorectal cancer, impact on proliferation, and role in colitis-associated cancer

Ida, S., Ozaki, N., Araki, K., Hirashima, K., Zaitsu, Y., Taki, K., Sakamoto, Y., Miyamoto, Y., Oki, E., Morita, M., Watanabe, M., Maehara, Y., Yamamura, K. I., Baba, H. & Ohmuraya, M., Jul 1 2015, In : Molecular Cancer Research. 13, 7, p. 1130-1138 9 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Suppressor microRNA-145 Is epigenetically regulated by promoter hypermethylation in esophageal squamous cell carcinoma

Harada, K., Baba, Y., Ishimoto, T., Kosumi, K., Tokunaga, R., Izumi, D., Ohuchi, M., Nakamura, K., Kiyozumi, Y., Kurashige, J., Iwagami, S., Miyamoto, Y., Sakamoto, Y., Yoshida, N., Oki, E., Watanabe, M. & Baba, H., Sep 1 2015, In : Anticancer research. 35, 9, p. 4617-4624 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

The 1,2-diaminocyclohexane carrier ligand in oxaliplatin induces p53-dependent transcriptional repression of factors involved in thymidylate biosynthesis

Kiyonari, S., Iimori, M., Matsuoka, K., Watanabe, S., Morikawa-Ichinose, T., Miura, D., Niimi, S., Saeki, H., Tokunaga, E., Oki, E., Morita, M., Kadomatsu, K., Maehara, Y. & Kitao, H., Oct 1 2015, In : Molecular cancer therapeutics. 14, 10, p. 2332-2342 11 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

The use of a circular side stapling technique in laparoscopic low anterior resection for rectal cancer: Experience of 30 serial cases

Oki, E., Ando, K., Saeki, H., Nakashima, Y., Kimura, Y., Hiyoshi, Y., Imamura, Y., Ohgaki, K., Ito, S., Morita, M., Ikeda, T. & Maehara, Y., Jun 2015, In : International Surgery. 100, 6, p. 979-983 5 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Thymoglobulin for steroid-resistant immune-mediated graft dysfunction during simeprevir-based antiviral treatment for post-transplantation hepatitis c: Case report

Takeishi, K., Ikegami, T., Yoshizumi, T., Itoh, S., Harimoto, N., Harada, N., Tsujita, E., Kimura, Y., Yamashita, Y., Saeki, K., Oki, E., Shirabe, K. & Maehara, Y., Apr 1 2015, In : Transplantation Proceedings. 47, 3, p. 794-795 2 p.

Research output: Contribution to journalArticle

Tracheobronchial fistula during the perioperative period of esophagectomy for esophageal cancer

Morita, M., Saeki, H., Okamoto, T., Oki, E., Yoshida, S. & Maehara, Y., May 1 2015, In : World journal of surgery. 39, 5, p. 1119-1126 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Treatment results of two-stage operation for the patients with esophageal cancer concomitant with liver dysfunction

Yasuda, M., Saeki, H., Nakashima, Y., Yukaya, T., Tsutsumi, S., Tajiri, H., Zaitsu, Y., Tsuda, Y., Kasagi, Y., Ando, K., Imamura, Y., Ohgaki, K., Akahoshi, T., Oki, E. & Maehara, Y., Sep 18 2015, In : Journal of Medical Investigation. 62, 3, p. 149-153 5 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Trifluridine induces p53-dependent sustained G2 phase arrest with its massive misincorporation into DNA and few DNA strand breaks

Matsuoka, K., Iimori, M., Niimi, S., Tsukihara, H., Watanabe, S., Kiyonari, S., Kiniwa, M., Ando, K., Tokunaga, E., Saeki, H., Oki, E., Maehara, Y. & Kitao, H., 2015, In : Molecular cancer therapeutics. 14, 4, p. 1004-1013 10 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Triple therapy using direct-acting agents for recurrent hepatitis C after liver transplantation: A single-center experience

Ikegami, T., Yoshizumi, T., Soejima, Y., Harimoto, N., Itoh, S., Takeishi, K., Uchiyama, H., Kawanaka, H., Yamashita, Y. I., Tsujita, E., Harada, N., Oki, E., Saeki, H., Kimura, Y., Shirabe, K. & Maehara, Y., Apr 1 2015, In : Transplantation Proceedings. 47, 3, p. 730-732 3 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2014

Aberrations of BUBR1 and TP53 gene mutually associated with chromosomal instability in human colorectal cancer

Zhao, Y., Ando, K., Oki, E., Ikawa-Yoshida, A., Ida, S., Kimura, Y., Saeki, H., Kitao, H., Morita, M. & Maehara, Y., Oct 1 2014, In : Anticancer research. 34, 10, p. 5421-5427 7 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Book-binding technique for billroth i anastomosis during totally laparoscopic distal gastrectomy

Oki, E., Tsuda, Y., Saeki, H., Ando, K., Imamura, Y., Nakashima, Y., Ohgaki, K., Morita, M., Ikeda, T. & Maehara, Y., 2014, In : Journal of the American College of Surgeons. 219, 6, p. e69-e73

Research output: Contribution to journalArticle

6 Citations (Scopus)

Chromosomal Instability Associated with Global DNA Hypomethylation is Associated with the Initiation and Progression of Esophageal Squamous Cell Carcinoma

Kawano, H., Saeki, H., Kitao, H., Tsuda, Y., Otsu, H., Ando, K., Ito, S., Egashira, A., Oki, E., Morita, M., Oda, Y. & Maehara, Y., 2014, In : Annals of Surgical Oncology. 21, 4, p. 696-702 7 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Clinical Outcomes and Prognostic Factors After Surgery for Non-Occlusive Mesenteric Ischemia: a Multicenter Study

Yukaya, T., Saeki, H., Taketani, K., Ando, K., Ida, S., Kimura, Y., Oki, E., Yasuda, M., Morita, M., Shirabe, K. & Maehara, Y., Sep 1 2014, In : Journal of Gastrointestinal Surgery. 18, 9, p. 1642-1647 6 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Contribution of Aurora-A and -B expression to DNA aneuploidy in gastric cancers

Honma, K., Nakanishi, R., Nakanoko, T., Ando, K., Saeki, H., Oki, E., Iimori, M., Kitao, H., Kakeji, Y. & Maehara, Y., Mar 2014, In : Surgery today. 44, 3, p. 454-461 8 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Erratum to: Rad51 Expression Is a Useful Predictive Factor for the Efficacy of Neoadjuvant Chemoradiotherapy in Squamous Cell Carcinoma of the Esophagus [Ann Surg Oncol, 10.1245/S10434-013-3220-2]

Nakanoko, T., Saeki, H., Morita, M., Nakashima, Y., Ando, K., Oki, E., Ohga, T., Kakeji, Y., Toh, Y. & Maehara, Y., Nov 19 2014, In : Annals of Surgical Oncology. 21, 4, p. 776 1 p.

Research output: Contribution to journalComment/debate

Gender differences in prognosis after esophagectomy for esophageal cancer

Morita, M., Otsu, H., Kawano, H., Kasagi, Y., Kimura, Y., Saeki, H., Ando, K., Ida, S., Oki, E., Tokunaga, E., Ikeda, T., Kusumoto, T. & Maehara, Y., Mar 2014, In : Surgery today. 44, 3, p. 505-512 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

IGF2 DMR0 methylation, loss of imprinting, and patient prognosis in esophageal squamous cell carcinoma

Murata, A., Baba, Y., Watanabe, M., Shigaki, H., Miyake, K., Ishimoto, T., Iwatsuki, M., Iwagami, S., Yoshida, N., Oki, E., Morita, M., Nakao, M. & Baba, H., Apr 2014, In : Annals of Surgical Oncology. 21, 4, p. 1166-1174 9 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

IgG4-related disease of the ileocecal region mimicking malignancy: A case report

Hiyoshi, Y., Oki, E., Zaitsu, Y., Ando, K., Ito, S., Saeki, H., Morita, M., Yamamoto, H., Baba, H. & Maehara, Y., Aug 9 2014, In : International Journal of Surgery Case Reports. 5, 10, p. 669-672 4 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Impact of second-line and later cetuximab-containing therapy and KRAS genotypes in patients with metastatic colorectal cancer: A multicenter study in Japan

Saeki, H., Emi, Y., Kumashiro, R., Otsu, H., Kawano, H., Ando, K., Ida, S., Kimura, Y., Tokunaga, E., Oki, E., Morita, M., Shimokawa, M. & Maehara, Y., Aug 2014, In : Surgery today. 44, 8, p. 1457-1464 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Intratumoral lymphangiogenesis and prognostic significance of VEGFC expression in gastric cancer

Ikeda, K., Oki, E., Saeki, H., Ando, K., Morita, M., Oda, Y., Imamura, M., Kakeji, Y. & Maehara, Y., Aug 1 2014, In : Anticancer research. 34, 8, p. 3911-3916 6 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

LINE-1 hypomethylation, DNA copy number alterations, and CDK6 amplification in esophageal squamous cell carcinoma

Baba, Y., Watanabe, M., Murata, A., Shigaki, H., Miyake, K., Ishimoto, T., Iwatsuki, M., Iwagami, S., Yoshida, N., Oki, E., Sakamaki, K., Nakao, M. & Baba, H., 2014, In : Clinical Cancer Research. 20, 5, p. 1114-1124 11 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Liver resectability of advanced liver-limited colorectal liver metastases following mFOLFOX6 with bevacizumab (KSCC0802 study)

KYUSHU STUDY GROUP OF CLINICAL CANCER (KSCC), Nov 1 2014, In : Anticancer research. 34, 11, p. 6655-6662 8 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Living donor liver transplantation followed by total gastrectomy - A two-stage planed operative strategy for early gastric cancer concomitant with decompensated liver cirrhosis

Nishimura, S., Saeki, H., Ikegami, T., Ando, K., Yamashita, Y. I., Oki, E., Yoshizumi, T., Morita, M., Shirabe, K. & Maehara, Y., Aug 1 2014, In : Anticancer research. 34, 8, p. 4307-4310 4 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Molecular mechanisms regulating the hormone sensitivity of breast cancer

Tokunaga, E., Hisamatsu, Y., Tanaka, K., Yamashita, N., Saeki, H., Oki, E., Kitao, H. & Maehara, Y., Nov 1 2014, In : Cancer Science. 105, 11, p. 1377-1383 7 p.

Research output: Contribution to journalReview article

18 Citations (Scopus)

Mortalin is a prognostic factor of gastric cancer with normal p53 function

Ando, K., Oki, E., Zhao, Y., Ikawa-Yoshida, A., Kitao, H., Saeki, H., Kimura, Y., Ida, S., Morita, M., Kusumoto, T. & Maehara, Y., Apr 2014, In : Gastric Cancer. 17, 2, p. 255-262 8 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Non-cirrhotic portal-systemic encephalopathy caused by enlargement of a splenorenal shunt after pancreaticoduodenectomy for locally advanced duodenal cancer: Report of a case

Kasagi, Y., Saeki, H., Akahoshi, T., Kawasaki, J., Ando, K., Oki, E., Ohga, T., Tomikawa, M., Kakeji, Y., Shirabe, K. & Maehara, Y., Aug 2014, In : Surgery today. 44, 8, p. 1573-1576 4 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Nuclear expression of chemokine receptor CXCR4 indicates poorer prognosis in gastric cancer

Masuda, T., Nakashima, Y., Ando, K., Yoshinaga, K., Saeki, H., Oki, E., Morita, M., Oda, Y. & Maehara, Y., Nov 1 2014, In : Anticancer research. 34, 11, p. 6397-6403 7 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Outcome of esophagojejunostomy during totally laparoscopic total gastrectomy: A single-center retrospective study

Hiyoshi, Y., Oki, E., Ando, K., Ito, S., Saeki, H., Morita, M., Baba, H. & Maehara, Y., Dec 1 2014, In : Anticancer research. 34, 12, p. 7227-7232 6 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Oxidative DNA damage in human esophageal cancer: Clinicopathological analysis of 8-hydroxydeoxyguanosine and its repair enzyme

Kubo, N., Morita, M., Nakashima, Y., Kitao, H., Egashira, A., Saeki, H., Oki, E., Kakeji, Y., Oda, Y. & Maehara, Y., Apr 2014, In : Diseases of the Esophagus. 27, 3, p. 285-293 9 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Phase II study of docetaxel and S-1 (DS) as neoadjuvant chemotherapy for clinical stage III resectable gastric cancer

Oki, E., Emi, Y., Kusumoto, T., Sakaguchi, Y., Yamamoto, M., Sadanaga, N., Shimokawa, M., Yamanaka, T., Saeki, H., Morita, M., Takahashi, I., Hirabayashi, N., Sakai, K., Orita, H., Aishima, S., Kakeji, Y., Yamaguchi, K., Yoshida, K., Baba, H. & Maehara, Y., Jul 2014, In : Annals of Surgical Oncology. 21, 7, p. 2340-2346 7 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Pure laparoscopic right-sided hepatectomy in the semi-prone position for synchronous colorectal cancer with liver metastases

Ida, S., Oki, E., Ando, K., Kimura, Y., Yamashita, Y. I., Saeki, H., Ikegami, T., Yoshizumi, T., Watanabe, M., Morita, M., Shirabe, K., Kusumoto, T., Ikeda, T., Baba, H. & Maehara, Y., May 1 2014, In : Asian journal of endoscopic surgery. 7, 2, p. 133-137 5 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Rad51 expression is a useful predictive factor for the efficacy of neoadjuvant chemoradiotherapy in squamous cell carcinoma of the esophagus

Nakanoko, T., Saeki, H., Morita, M., Nakashima, Y., Ando, K., Oki, E., Ohga, T., Kakeji, Y., Toh, Y. & Maehara, Y., Feb 2014, In : Annals of Surgical Oncology. 21, 2, p. 597-604 8 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Significance of accurate human epidermal growth factor receptor-2 (HER2) evaluation as a new biomarker in gastric cancer

Kimura, Y., Oki, E., Yoshida, A., Aishima, S., Zaitsu, Y., Ohtsu, H., Ando, K., Ida, S., Saeki, H., Morita, M., Kusumoto, T., Oda, Y. & Maehara, Y., Aug 1 2014, In : Anticancer research. 34, 8, p. 4207-4212 6 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)