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  • Hiroyuki Kitao

Activation of the FA pathway mediated by phosphorylation and ubiquitination

Ishiai, M., Sato, K., Tomida, J., Kitao, H., Kurumizaka, H. & Takata, M., Oct 2017, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 803-805, p. 89-95 7 p.

Research output: Contribution to journalReview article

8 Citations (Scopus)

A minimal threshold of FANCJ helicase activity is required for its response to replication stress or double-strand break repair

Bharti, S. K., Sommers, J. A., Awate, S., Bellani, M. A., Khan, I., Bradley, L., King, G. A., Seol, Y., Vidhyasagar, V., Wu, Y., Abe, T., Kobayashi, K., Shin-Ya, K., Kitao, H., Wold, M. S., Branzei, D., Neuman, K. C. & Brosh, R. M., Jul 6 2018, In : Nucleic acids research. 46, 12, p. 6238-6256 19 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Antitumor Molecular Mechanism of Trifluridine and Tipiracil Hydrochloride (TAS-102: TFTD)

Kitao, H., Matsuoka, K., Iimori, M., Tokunaga, E., Saeki, H., Oki, E., Miyamoto, Y., Baba, H. & Maehara, Y., Jan 1 2016, In : Gan to kagaku ryoho. Cancer & chemotherapy. 43, 1, p. 8-14 7 p.

Research output: Contribution to journalReview article

ATR-Chk1 signaling pathway and homologous recombinational repair protect cells from 5-fluorouracil cytotoxicity

Fujinaka, Y., Matsuoka, K., Iimori, M., Tuul, M., Sakasai, R., Yoshinaga, K., Saeki, H., Morita, M., Kakeji, Y., Gillespie, D. A., Yamamoto, K. I., Takata, M., Kitao, H. & Maehara, Y., Mar 1 2012, In : DNA Repair. 11, 3, p. 247-258 12 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Biological and clinical significance of loss of heterozygosity at the INPP4B gene locus in Japanese breast cancer

Tokunaga, E., Yamashita, N., Kitao, H., Tanaka, K., Taketani, K., Inoue, Y., Saeki, H., Oki, E., Oda, Y. & Maehara, Y., Feb 1 2016, In : Breast. 25, p. 62-68 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Clinical Significance of the Wild Type p53-Induced Phosphatase 1 Expression in Invasive Breast Cancer

Inoue, Y., Yamashita, N., Kitao, H., Tanaka, K., Saeki, H., Oki, E., Oda, Y., Tokunaga, E. & Maehara, Y., Aug 2018, In : Clinical Breast Cancer. 18, 4, p. e643-e650

Research output: Contribution to journalArticle

2 Citations (Scopus)

Contribution of BubR1 to oxidative stress-induced aneuploidy in p53-deficient cells

Ikawa-Yoshida, A., Ando, K., Oki, E., Saeki, H., Kumashiro, R., Taketani, K., Ida, S., Tokunaga, E., Kitao, H., Morita, M. & Maehara, Y., Aug 2013, In : Cancer Medicine. 2, 4, p. 447-456 10 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Copy-neutral loss of heterozygosity at the p53 locus in carcinogenesis of esophageal squamous cell carcinomas associated with p53 mutations

Saeki, H., Kitao, H., Yoshinaga, K., Nakanoko, T., Kubo, N., Kakeji, Y., Morita, M. & Maehara, Y., Apr 1 2011, In : Clinical Cancer Research. 17, 7, p. 1731-1740 10 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

CtIP- and ATR-dependent FANCJ phosphorylation in response to DNA strand breaks mediated by DNA replication

Sakasai, R., Sakai, A., Iimori, M., Kiyonari, S., Matsuoka, K., Kakeji, Y., Kitao, H. & Maehara, Y., Dec 1 2012, In : Genes to Cells. 17, 12, p. 962-970 9 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Discrimination of p53 immunohistochemistry-positive tumors by its staining pattern in gastric cancer

Ando, K., Oki, E., Saeki, H., Yan, Z., Tsuda, Y., Hidaka, G., Kasagi, Y., Otsu, H., Kawano, H., Kitao, H., Morita, M. & Maehara, Y., Jan 1 2015, In : Cancer Medicine. 4, 1, p. 75-83 9 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

DNA replication stress and cancer chemotherapy

Kitao, H., Iimori, M., Kataoka, Y., Wakasa, T., Tokunaga, E., Saeki, H., Oki, E. & Maehara, Y., Feb 1 2018, In : Cancer Science. 109, 2, p. 264-271 8 p.

Research output: Contribution to journalReview article

11 Citations (Scopus)

Epigenetic inactivation of BRCA1 through promoter hypermethylation and its clinical importance in triple-negative breast cancer

Yamashita, N., Tokunaga, E., Kitao, H., Hitchins, M., Inoue, Y., Tanaka, K., Hisamatsu, Y., Taketani, K., Akiyoshi, S., Okada, S., Oda, Y., Saeki, H., Oki, E. & Maehara, Y., Dec 2015, In : Clinical Breast Cancer. 15, 6, p. 498-504 7 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Epithelial Paradox: Clinical Significance of Coexpression of E-cadherin and Vimentin With Regard to Invasion and Metastasis of Breast Cancer

Yamashita, N., Tokunaga, E., Iimori, M., Inoue, Y., Tanaka, K., Kitao, H., Saeki, H., Oki, E. & Maehara, Y., Oct 2018, In : Clinical Breast Cancer. 18, 5, p. e1003-e1009

Research output: Contribution to journalArticle

13 Citations (Scopus)

Evaluation of homologous recombinational repair in chicken B lymphoma cell line, DT40.

Kitao, H., Hirano, S. & Takata, M., Oct 4 2011, In : Methods in molecular biology (Clifton, N.J.). 745, p. 293-309 17 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Evolving 5-fluorouracil therapy to achieve enhanced efficacy-past and current efforts of researchers

Maehara, Y., Oki, E., Saeki, H., Tokunaga, E., Kitao, H., Iimori, M., Niimi, S., Kataoka, Y., Emi, Y., Kakeji, Y., Baba, H. & Shirasaka, T., Jul 2016, In : Japanese Journal of Cancer and Chemotherapy. 43, 7, p. 845-854 10 p.

Research output: Contribution to journalReview article

Expression of APOBEC3B mRNA in primary breast cancer of Japanese women

Tokunaga, E., Yamashita, N., Tanaka, K., Inoue, Y., Akiyoshi, S., Saeki, H., Oki, E., Kitao, H. & Maehara, Y., Dec 2016, In : PloS one. 11, 12, e0168090.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Expression of PD-L1 and HLA Class I in Esophageal Squamous Cell Carcinoma: Prognostic Factors for Patient Outcome

Ito, S., Okano, S., Morita, M., Saeki, H., Tsutsumi, S., Tsukihara, H., Nakashima, Y., Ando, K., Imamura, Y., Ohgaki, K., Oki, E., Kitao, H., Mimori, K. & Maehara, Y., Aug 1 2016, In : Annals of Surgical Oncology. 23, p. 508-515 8 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

FancJ/Brip1 helicase protects against genomic losses and gains in vertebrate cells

Kitao, H., Nanda, I., Sugino, R. P., Kinomura, A., Yamazoe, M., Arakawa, H., Schmid, M., Innan, H., Hiom, K. & Takata, M., Jun 1 2011, In : Genes to Cells. 16, 6, p. 714-727 14 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

FANCJ expression predicts the response to 5-fluorouracil-based chemotherapy in MLH1-proficient colorectal cancer

Nakanishi, R., Kitao, H., Fujinaka, Y., Yamashita, N., Iimori, M., Tokunaga, E., Yamashita, N., Morita, M., Kakeji, Y. & Maehara, Y., Oct 1 2012, In : Annals of Surgical Oncology. 19, 11, p. 3627-3635 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Fanconi anemia: A disorder defective in the DNA damage response

Kitao, H. & Takata, M., Apr 1 2011, In : International journal of hematology. 93, 4, p. 417-424 8 p.

Research output: Contribution to journalReview article

53 Citations (Scopus)

Fanconi anemia group J mutation abolishes its DNA repair function by uncoupling DNA translocation from helicase activity or disruption of protein-DNA complexes

Wu, Y., Sommers, J. A., Suhasini, A. N., Leonard, T., Deakyne, J. S., Mazin, A. V., Shin-ya, K., Kitao, H. & Brosh, R. M., Nov 11 2010, In : Blood. 116, 19, p. 3780-3791 12 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)

Gastric Cancer Patients with High PLK1 Expression and DNA Aneuploidy Correlate with Poor Prognosis

Otsu, H., Iimori, M., Ando, K., Saeki, H., Aishima, S., Oda, Y., Morita, M., Matsuo, K., Kitao, H., Oki, E. & Maehara, Y., Jul 1 2016, In : Oncology (Switzerland). 91, 1, p. 31-40 10 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

High expression of BUBR1 is one of the factors for inducing DNA aneuploidy and progression in gastric cancer

Ando, K., Kakeji, Y., Kitao, H., Iimori, M., Zhao, Y., Yoshida, R., Oki, E., Yoshinaga, K., Matumoto, T., Morita, M., Sakaguchi, Y. & Maehara, Y., Mar 1 2010, In : Cancer Science. 101, 3, p. 639-645 7 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

High expression of the Notch ligand Jagged-1 is associated with poor prognosis after surgery for colorectal cancer

Sugiyama, M., Oki, E., Nakaji, Y., Tsutsumi, S., Ono, N., Nakanishi, R., Sugiyama, M., Nakashima, Y., Sonoda, H., Ohgaki, K., Yamashita, N., Saeki, H., Okano, S., Kitao, H., Morita, M., Oda, Y. & Maehara, Y., Nov 1 2016, In : Cancer Science. 107, 11, p. 1705-1716 12 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

High incidence and frequency of LOH are associated with aggressive features of high-grade HER2 and triple-negative breast cancers

Tokunaga, E., Okada, S., Yamashita, N., Akiyoshi, S., Kitao, H., Morita, M., Kakeji, Y. & Maehara, Y., Apr 1 2012, In : Breast Cancer. 19, 2, p. 161-169 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Histone chaperone activity of Fanconi anemia proteins, FANCD2 and FANCI, is required for DNA crosslink repair

Sato, K., Ishiai, M., Toda, K., Furukoshi, S., Osakabe, A., Tachiwana, H., Takizawa, Y., Kagawa, W., Kitao, H., Dohmae, N., Obuse, C., Kimura, H., Takata, M. & Kurumizaka, H., Aug 29 2012, In : EMBO Journal. 31, 17, p. 3524-3536 13 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Impact of Expression of Vimentin and Axl in Breast Cancer

Tanaka, K., Tokunaga, E., Inoue, Y., Yamashita, N., Saeki, H., Okano, S., Kitao, H., Oki, E., Oda, Y. & Maehara, Y., Dec 1 2016, In : Clinical Breast Cancer. 16, 6, p. 520-526.e2

Research output: Contribution to journalArticle

13 Citations (Scopus)

Intensive immunofluorescence staining methods for low expression protein: Detection of intestinal stem cell marker LGR5

Yamazaki, M., Kato, A., Zaitsu, Y., Watanabe, T., Iimori, M., Funahashi, S., Kitao, H., Saeki, H., Oki, E. & Suzuki, M., Oct 29 2015, In : Acta Histochemica et Cytochemica. 48, 5, p. 159-164 6 p.

Research output: Contribution to journalComment/debate

3 Citations (Scopus)

Involvement of ribonucleotide reductase-M1 in 5-fluorouracil.-induced DNA damage in esophageal cancer cell lines

Aoki, Y., Sakogawa, K., Hihara, J., Emi, M., Hamai, Y., Kono, K., Shi, L., Sun, J., Kitao, H., Ikura, T., Niida, H., Nakanishi, M., Okada, M. & Tashiro, S., Jun 1 2013, In : International journal of oncology. 42, 6, p. 1951-1960 10 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Loss of heterozygosity at BRCA1 locus is significantly associated with aggressiveness and poor prognosis in breast cancer

Okada, S., Tokunaga, E., Kitao, H., Akiyoshi, S., Yamashita, N., Saeki, H., Oki, E., Morita, M., Kakeji, Y. & Maehara, Y., May 1 2012, In : Annals of Surgical Oncology. 19, 5, p. 1499-1507 9 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Low incidence of methylation of the promoter region of the FANCF gene in Japanese primary breast cancer

Tokunaga, E., Okada, S., Kitao, H., Shiotani, S., Saeki, H., Endo, K., Morita, M., Kakeji, Y. & Maehara, Y., Apr 1 2011, In : Breast Cancer. 18, 2, p. 120-123 4 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

MDC1 methylation mediated by lysine methyltransferases EHMT1 and EHMT2 regulates active ATM accumulation flanking DNA damage sites

Watanabe, S., Iimori, M., Chan, D. V., Hara, E., Kitao, H. & Maehara, Y., Dec 1 2018, In : Scientific reports. 8, 1, 10888.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Mitotic slippage and the subsequent cell fates after inhibition of Aurora B during tubulin-binding agent-induced mitotic arrest

Tsuda, Y., Iimori, M., Nakashima, Y., Nakanishi, R., Ando, K., Ohgaki, K., Kitao, H., Saeki, H., Oki, E. & Maehara, Y., Dec 1 2017, In : Scientific reports. 7, 1, 16762.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Monitoring trifluridine incorporation in the peripheral blood mononuclear cells of colorectal cancer patients under trifluridine/tipiracil medication

Nakanishi, R., Kitao, H., Kiniwa, M., Morodomi, Y., Iimori, M., Kurashige, J., Sugiyama, M., Nakashima, Y., Saeki, H., Oki, E. & Maehara, Y., Dec 1 2017, In : Scientific reports. 7, 1, 16969.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Oxaliplatin - A 10-year trajectory

Kanaji, S., Oki, E., Saeki, H., Kitao, H., Maehara, Y. & Kakeji, Y., Jun 2016, In : Japanese Journal of Cancer and Chemotherapy. 43, 6, p. 715-722 8 p.

Research output: Contribution to journalReview article

Oxaliplatin -- A 10-Year Trajectory

Kanaji, S., Oki, E., Saeki, H., Kitao, H., Maehara, Y. & Kakeji, Y., Jun 1 2016, In : Gan to kagaku ryoho. Cancer & chemotherapy. 43, 6, p. 715-722 8 p.

Research output: Contribution to journalArticle

PARP and CSB modulate the processing of transcription-mediated DNA strand breaks

Sakai, A., Sakasai, R., Kakeji, Y., Kitao, H. & Maehara, Y., Jan 1 2012, In : Genes and Genetic Systems. 87, 4, p. 265-272 8 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Phosphorylation of EB2 by Aurora B and CDK1 ensures mitotic progression and genome stability

Iimori, M., Watanabe, S., Kiyonari, S., Matsuoka, K., Sakasai, R., Saeki, H., Oki, E., Kitao, H. & Maehara, Y., Mar 31 2016, In : Nature communications. 7, 11117.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Podoplanin is expressed at the invasive front of esophageal squamous cell carcinomas and is involved in collective cell invasion

Nakashima, Y., Yoshinaga, K., Kitao, H., Ando, K., Kimura, Y., Saeki, H., Oki, E., Morita, M., Kakeji, Y., Hirahashi, M., Oda, Y. & Maehara, Y., Dec 1 2013, In : Cancer Science. 104, 12, p. 1718-1725 8 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Prognostic impact of MutT homolog-1 expression on esophageal squamous cell carcinoma

Akiyama, S., Saeki, H., Nakashima, Y., Iimori, M., Kitao, H., Oki, E., Oda, Y., Nakabeppu, Y., Kakeji, Y. & Maehara, Y., Jan 1 2017, In : Cancer Medicine. 6, 1, p. 258-266 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Prognostic relevance of KRAS and BRAF mutations in Japanese patients with colorectal cancer

Nakanishi, R., Harada, J., Tuul, M., Zhao, Y., Ando, K., Saeki, H., Oki, E., Ohga, T., Kitao, H., Kakeji, Y. & Maehara, Y., Dec 1 2013, In : International Journal of Clinical Oncology. 18, 6, p. 1042-1048 7 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Rad9, Rad17, TopBP1 and Claspin Play Essential Roles in Heat-Induced Activation of ATR Kinase and Heat Tolerance

Tuul, M., Kitao, H., Iimori, M., Matsuoka, K., Kiyonari, S., Saeki, H., Oki, E., Morita, M. & Maehara, Y., Feb 1 2013, In : PloS one. 8, 2, e55361.

Research output: Contribution to journalArticle

13 Citations (Scopus)

The 1,2-diaminocyclohexane carrier ligand in oxaliplatin induces p53-dependent transcriptional repression of factors involved in thymidylate biosynthesis

Kiyonari, S., Iimori, M., Matsuoka, K., Watanabe, S., Morikawa-Ichinose, T., Miura, D., Niimi, S., Saeki, H., Tokunaga, E., Oki, E., Morita, M., Kadomatsu, K., Maehara, Y. & Kitao, H., Oct 1 2015, In : Molecular Cancer Therapeutics. 14, 10, p. 2332-2342 11 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

The antibodies against 5-bromo-2′-deoxyuridine specifically recognize trifluridine incorporated into DNA

Kitao, H., Morodomi, Y., Niimi, S., Kiniwa, M., Shigeno, K., Matsuoka, K., Kataoka, Y., Iimori, M., Tokunaga, E., Saeki, H., Oki, E. & Maehara, Y., May 3 2016, In : Scientific reports. 6, 25286.

Research output: Contribution to journalArticle

14 Citations (Scopus)

The molecular aspect of the antitumor effect of oxaliplatin in combination with 5-FU

Kitao, H., Kiyonari, S., Limori, M., Niimi, S., Kataoka, Y., Akiyama, S., Edahiro, K., Nakanishi, R., Tokunaga, E., Saeki, H., Oki, E., Kanaji, S., Kakeji, Y. & Maehara, Y., Jun 2016, In : Japanese Journal of Cancer and Chemotherapy. 43, 6, p. 707-714 8 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)

The Molecular Aspect of the Antitumor Effect of Oxaliplatin in Combination with 5-FU

Kitao, H., Kiyonari, S., Iimori, M., Niimi, S., Kataoka, Y., Akiyama, S., Edahiro, K., Nakanishi, R., Tokunaga, E., Saeki, H., Oki, E., Kanaji, S., Kakeji, Y. & Maehara, Y., Jun 1 2016, In : Gan to kagaku ryoho. Cancer & chemotherapy. 43, 6, p. 707-714 8 p.

Research output: Contribution to journalArticle

The Q motif of fanconi anemia group J protein (FANCJ) DNA helicase regulates its dimerization, DNA binding, and DNA repair function

Wu, Y., Sommers, J. A., Loiland, J. A., Kitao, H., Kuper, J., Kisker, C. & Brosh, R. M., Jun 22 2012, In : Journal of Biological Chemistry. 287, 26, p. 21699-21716 18 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Thymidine kinase 1 loss confers trifluridine resistance without affecting 5-fluorouracil metabolism and cytotoxicity

Edahiro, K., Iimori, M., Kobunai, T., Morikawa-Ichinose, T., Miura, D., Kataoka, Y., Niimi, S., Wakasa, T., Saeki, H., Oki, E., Kitao, H. & Maehara, Y., Oct 2018, In : Molecular Cancer Research. 16, 10, p. 1483-1490 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Trifluridine induces p53-dependent sustained G2 phase arrest with its massive misincorporation into DNA and few DNA strand breaks

Matsuoka, K., Iimori, M., Niimi, S., Tsukihara, H., Watanabe, S., Kiyonari, S., Kiniwa, M., Ando, K., Tokunaga, E., Saeki, H., Oki, E., Maehara, Y. & Kitao, H., Jan 1 2015, In : Molecular Cancer Therapeutics. 14, 4, p. 1004-1013 10 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Vimentin as a poor prognostic factor for triple-negative breast cancer

Yamashita, N., Tokunaga, E., Kitao, H., Hisamatsu, Y., Taketani, K., Akiyoshi, S., Okada, S., Aishima, S., Morita, M. & Maehara, Y., May 1 2013, In : Journal of Cancer Research and Clinical Oncology. 139, 5, p. 739-746 8 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)