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  • Hiroaki Niiro
2019

CCR6+ group 3 innate lymphoid cells accumulate in inflamed joints in rheumatoid arthritis and produce Th17 cytokines

Takaki-Kuwahara, A., Arinobu, Y., Miyawaki, K., Yamada, H., Tsuzuki, H., Irino, K., Ayano, M., Kimoto, Y., Mitoma, H., Akahoshi, M., Tsukamoto, H., Horiuchi, T., Niiro, H. & Akashi, K., Aug 30 2019, In : Arthritis Research and Therapy. 21, 1, 198.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
1 Citation (Scopus)

Serum levels of fibroblast growth factor-2 distinguish Takayasu arteritis from giant cell arteritis independent of age at diagnosis

Fukui, S., Kuwahara-Takaki, A., Ono, N., Sato, S., Koga, T., Kawashiri, S. Y., Iwanaga, N., Iwamoto, N., Ichinose, K., Tamai, M., Nakamura, H., Origuchi, T., Migita, K., Arinobu, Y., Niiro, H., Tada, Y., Akashi, K., Maeda, T. & Kawakami, A., Dec 1 2019, In : Scientific reports. 9, 1, 688.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2018

Activation of central/effector memory T cells and T-helper 1 polarization in malignant melanoma patients treated with anti-programmed death-1 antibody

Yamaguchi, K., Mishima, K., Ohmura, H., Hanamura, F., Ito, M., Nakano, M., Tsuchihashi, K., Ota, S. I., Wada, N., Uchi, H., Ariyama, H., Kusaba, H., Niiro, H., Akashi, K. & Baba, E., Oct 2018, In : Cancer Science. 109, 10, p. 3032-3042 11 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
5 Citations (Scopus)
2017

Functional interleukin-33 receptors are expressed in early progenitor stages of allergy-related granulocytes

Tsuzuki, H., Arinobu, Y., Miyawaki, K., Takaki, A., Ota, S. I., Ota, Y., Mitoma, H., Akahoshi, M., Mori, Y., Iwasaki, H., Niiro, H., Tsukamoto, H. & Akashi, K., Jan 1 2017, In : Immunology. 150, 1, p. 64-73 10 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Genome-wide Association Study of Idiopathic Osteonecrosis of the Femoral Head

Sakamoto, Y., Yamamoto, T., Sugano, N., Takahashi, D., Watanabe, T., Atsumi, T., Nakamura, J., Hasegawa, Y., Akashi, K., Narita, I., Miyamoto, T., Takeuchi, T., Ikari, K., Amano, K., Fujie, A., Kubo, T., Tada, Y., Kaneuji, A., Nakamura, H., Miyamura, T. & 70 others, Kabata, T., Yamaji, K., Okawa, T., Sudo, A., Ohzono, K., Tanaka, Y., Yasunaga, Y., Matsuda, S., Imai, Y., Nakashima, Y., Motomura, G., Ikemura, S., Yamaguchi, R., Karasuyama, K., Sonoda, K., Nishii, T., Sakai, T., Takao, M., Irie, T., Asano, T., Iwasaki, N., Atsumi, T., Tamaoki, S., Nakanishi, R., Tanabe, S., Kishida, S., Hagiwara, S., Seki, T., Tsukamoto, H., Niiro, H., Arinobu, Y., Akahoshi, M., Mitoma, H., Ayano, M., Kuroda, T., Toyama, Y., Funayama, A., Hanaoka, H., Yamaoka, K., Kawaguchi, Y., Yamanaka, H., Hosozawa, T., Momohara, S., Chino, K., Fujioka, M., Ueshima, K., Ishida, M., Saito, M., Hayashi, S., Ikegami, A., Ichiseki, T., Mizokawa, S., Ohta, Y., Kajino, Y., Sekiya, F., Higuchi, F., Hasegawa, M., Miyamoto, N., Miyazaki, S., Yamaguchi, T., Ando, W., Saito, K., Nakano, K., Kuroda, Y., Yamasaki, T., Akiyama, M., Kubo, M., Kamatani, Y., Iwamoto, Y. & Ikegawa, S., Dec 1 2017, In : Scientific reports. 7, 1, 15035.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Musashi-1 is the candidate of the regulator of hair cell progenitors during inner ear regeneration

Wakasaki, T., Niiro, H., Jabbarzadeh-Tabrizi, S., Ohashi, M., Kimitsuki, T., Nakagawa, T., Komune, S. & Akashi, K., Aug 16 2017, In : BMC Neuroscience. 18, 1, 64.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2016

Bi-cytopenia possibly induced by anti-PD-1 antibody for primary malignant melanoma of the esophagus A case report

Inadomi, K., Kumagai, H., Arita, S., Tsuruta, N., Takayoshi, K., Mishima, K., Ota, S. I., Tanaka, M., Okumura, Y., Sagara, K., Nio, K., Nakano, M., Uchi, H., Yamamoto, H., Ariyama, H., Kusaba, H., Niiro, H., Oda, Y., Akashi, K. & Baba, E., Jul 26 2016, In : Medicine (United States). 95, 29, e4283.

Research output: Contribution to journalArticle

16 Citations (Scopus)
54 Citations (Scopus)

Generation mechanism of RANKL+ effector memory B cells: Relevance to the pathogenesis of rheumatoid arthritis

Ota, Y., Niiro, H., Ota, S. I., Ueki, N., Tsuzuki, H., Nakayama, T., Mishima, K., Higashioka, K., Jabbarzadeh-Tabrizi, S., Mitoma, H., Akahoshi, M., Arinobu, Y., Kukita, A., Yamada, H., Tsukamoto, H. & Akashi, K., Mar 16 2016, In : Arthritis Research and Therapy. 18, 1, 67.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Long-term clinical safety and efficacy of brodalumab in the treatment of Japanese patients with moderate-to-severe plaque psoriasis

the Japanese Brodalumab Study Group, Nov 1 2016, In : Journal of the European Academy of Dermatology and Venereology. 30, 11, p. 1957-1960 4 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Renal insufficiency in concert with renin-angiotensinaldosterone inhibition is a major risk factor for hyperkalemia associated with low-dose trimethoprim-sulfamethoxazole in adults

Higashioka, K., Niiro, H., Yoshida, K., Oryoji, K., Kamada, K., Mizuki, S. & Yokota, E., Mar 1 2016, In : Internal Medicine. 55, 5, p. 467-471 5 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Safety, pharmacokinetics, and pharmacodynamics of epratuzumab in Japanese patients with moderate-to-severe systemic lupus erythematosus: Results from a phase 1/2 randomized study

Tsuru, T., Tanaka, Y., Kishimoto, M., Saito, K., Yoshizawa, S., Takasaki, Y., Miyamura, T., Niiro, H., Morimoto, S., Yamamoto, J., Lledo-Garcia, R., Shao, J., Tatematsu, S., Togo, O. & Koike, T., Jan 2 2016, In : Modern Rheumatology. 26, 1, p. 87-93 7 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2015

Amplification of IL-21 signalling pathway through bruton's tyrosine kinase in human B cell activation

Wang, S. P., Iwata, S., Nakayamada, S., Niiro, H., Jabbarzadeh-Tabrizi, S., Kondo, M., Kubo, S., Yoshikawa, M. & Tanaka, Y., May 5 2015, In : Rheumatology (United Kingdom). 54, 8, p. 1488-1497 10 p., keu532.

Research output: Contribution to journalArticle

19 Citations (Scopus)

A TIM-3/Gal-9 Autocrine Stimulatory Loop Drives Self-Renewal of Human Myeloid Leukemia Stem Cells and Leukemic Progression

Kikushige, Y., Miyamoto, T., Yuda, J., Jabbarzadeh-Tabrizi, S., Shima, T., Takayanagi, S. I., Niiro, H., Yurino, A., Miyawaki, K., Takenaka, K., Iwasaki, H. & Akashi, K., Sep 3 2015, In : Cell stem cell. 17, 3, p. 341-352 12 p., 1815.

Research output: Contribution to journalArticle

54 Citations (Scopus)

Characteristics of MPO-ANCA-positive granulomatosis with polyangiitis: a retrospective multi-center study in Japan

Ono, N., Niiro, H., Ueda, A., Sawabe, T., Nishizaka, H., Furugo, I., Yoshizawa, S., Yoshizawa, S., Tsukamoto, H., Kiyohara, C., Tada, Y. & Horiuchi, T., Jan 1 2015, In : Rheumatology International. 35, 3, p. 555-559 5 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Effector B cells in autoimmune diseases

Niiro, H., Jan 1 2015, In : Japanese Journal of Clinical Immunology. 38, 5, p. 412-420 9 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Increased Syk phosphorylation leads to overexpression of TRAF6 in peripheral B cells of patients with systemic lupus erythematosus

Iwata, S., Yamaoka, K., Niiro, H., Jabbarzadeh-Tabrizi, S., Wang, S. P., Kondo, M., Yoshikawa, M., Akashi, K. & Tanaka, Y., Jun 3 2015, In : Lupus. 24, 7, p. 695-704 10 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Microarray analysis of gene expression in fibrovascular membranes excised from patients with proliferative diabetic retinopathy

Ishikawa, K., Yoshida, S., Kobayashi, Y., Zhou, Y., Nakama, T., Nakao, S., Sassa, Y., Oshima, Y., Niiro, H., Akashi, K., Kono, T. & Ishibashi, T., Jan 1 2015, In : Investigative Ophthalmology and Visual Science. 56, 2, p. 932-946 15 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)
8 Citations (Scopus)
2013

Four cases of MPO-ANCA-positive vasculitis with otitis media, and review of the literature

Ono, N., Yoshihiro, K., Oryoji, D., Matsuda, M., Ueki, Y., Uezono, S., Kai, Y., Himeji, D., Niiro, H. & Ueda, A., May 1 2013, In : Modern Rheumatology. 23, 3, p. 554-563 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

PU.1 is a potent tumor suppressor in classical Hodgkin lymphoma cells

Yuki, H., Ueno, S., Tatetsu, H., Niiro, H., Iino, T., Endo, S., Kawano, Y., Komohara, Y., Takeya, M., Hata, H., Okada, S., Watanabe, T., Akashi, K., Mitsuya, H. & Okuno, Y., Feb 7 2013, In : Blood. 121, 6, p. 962-970 9 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

The cytotoxic effects of certolizumab pegol and golimumab mediated by transmembrane tumor necrosis factorα

Ueda, N., Tsukamoto, H., Mitoma, H., Ayano, M., Tanaka, A., Ohta, S. I., Inoue, Y., Arinobu, Y., Niiro, H., Akashi, K. & Horiuchi, T., May 1 2013, In : Inflammatory bowel diseases. 19, 6, p. 1224-1231 8 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)
2012

Amplification of Toll-like receptor-mediated signaling through spleen tyrosine kinase in human B-cell activation

Iwata, S., Yamaoka, K., Niiro, H., Nakano, K., Wang, S. P., Akashi, K. & Tanaka, Y., Jun 2012, In : Journal of Allergy and Clinical Immunology. 129, 6, p. 1594-1601.e2

Research output: Contribution to journalArticle

21 Citations (Scopus)

Cigarette smoking, alcohol consumption, and risk of systemic lupus erythematosus: A case-control study in a Japanese population

Kiyohara, C., Washio, M., Horiuchi, T., Asami, T., Ide, S., Atsumi, T., Kobashi, G., Tada, Y., Takahashi, H., Kodama, H., Akashi, K., Harada, M., Niiro, H., Tsukamoto, H., Hotokebuchi, T., Nagasawa, K., Ushiyama, O., Mori, M., Oura, A., Sinomura, Y. & 15 others, Suzuki, H., Yamamoto, M., Horita, T., Koike, T., Abe, T., Tanaka, H., Nogami, N., Okamoto, K., Sakamoto, N., Sasaki, S., Miyake, Y., Yokoyama, T., Hirota, Y., Inaba, Y. & Nagai, M., Jul 1 2012, In : Journal of Rheumatology. 39, 7, p. 1363-1370 8 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

CIN85 is required for Cbl-mediated regulation of antigen receptor signaling in human B cells

Niiro, H., Jabbarzadeh-Tabrizi, S., Kikushige, Y., Shima, T., Noda, K., Ota, S. I., Tsuzuki, H., Inoue, Y., Arinobu, Y., Iwasaki, H., Shimoda, S., Baba, E., Tsukamoto, H., Horiuchi, T., Taniyama, T. & Akashi, K., Mar 8 2012, In : Blood. 119, 10, p. 2263-2273 11 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Hereditary angioedema in Japan: Genetic analysis of 13 unrelated cases

Yamamoto, T., Horiuchi, T., Miyahara, H., Yoshizawa, S., Maehara, J., Shono, E., Takamura, K., MacHida, H., Tsujioka, K., Kaneko, T., Uemura, N., Suzawa, K., Inagaki, N., Umegaki, N., Kasamatsu, Y., Hara, A., Arinobu, Y., Inoue, Y., Niiro, H., Kashiwagai, Y. & 4 others, Harashima, S. I., Tahira, T., Tsukamoto, H. & Akashi, K., Mar 2012, In : American Journal of the Medical Sciences. 343, 3, p. 210-214 5 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Involvement of Syk in pathology of systemic autoimmune disease

Iwata, S., Yamaoka, K., Nakano, K., Wang, S. P., Saito, K., Tanaka, Y., Niiro, H. & Akashi, K., Jan 1 2012, In : Japanese Journal of Clinical Immunology. 35, 1, p. 56-61 6 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Serum progranulin levels are elevated in patients with systemic lupus erythematosus, reflecting disease activity

Tanaka, A., Tsukamoto, H., Mitoma, H., Kiyohara, C., Ueda, N., Ayano, M., Ohta, S. I., Inoue, Y., Arinobu, Y., Niiro, H., Horiuchi, T. & Akashi, K., Nov 11 2012, In : Arthritis Research and Therapy. 14, 6, R244.

Research output: Contribution to journalArticle

46 Citations (Scopus)

The role of natural killer (NK) and NKT cells in the loss of tolerance in murine primary biliary cirrhosis

Shimoda, S., Tsuneyama, K., Kikuchi, K., Harada, K., Nakanuma, Y., Nakamura, M., Ishibashi, H., Hisamoto, S., Niiro, H., Leung, P. S. C., Ansari, A. A., Gershwin, M. E. & Akashi, K., Jun 1 2012, In : Clinical and Experimental Immunology. 168, 3, p. 279-284 6 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
2011

Analysis of immune reconstitution after autologous CD34 + stem/progenitor cell transplantation for systemic sclerosis: Predominant reconstitution of Th1 CD4 + t cells

Tsukamoto, H., Nagafuji, K., Horiuchi, T., Mitoma, H., Niiro, H., Arinobu, Y., Inoue, Y., To, K., Miyamoto, T., Iwasaki, H., Teshima, T., Harada, M. & Akashi, K., May 1 2011, In : Rheumatology. 50, 5, p. 944-952 9 p., keq414.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Interaction between Toll-like receptors and natural killer cells in the destruction of bile ducts in primary biliary cirrhosis

Shimoda, S., Harada, K., Niiro, H., Shirabe, K., Taketomi, A., Maehara, Y., Tsuneyama, K., Nakanuma, Y., Leung, P., Ansari, A. A., Gershwin, M. E. & Akashi, K., Apr 1 2011, In : Hepatology. 53, 4, p. 1270-1281 12 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)

Self-Renewing Hematopoietic Stem Cell Is the Primary Target in Pathogenesis of Human Chronic Lymphocytic Leukemia

Kikushige, Y., Ishikawa, F., Miyamoto, T., Shima, T., Urata, S., Yoshimoto, G., Mori, Y., Iino, T., Yamauchi, T., Eto, T., Niiro, H., Iwasaki, H., Takenaka, K. & Akashi, K., Aug 16 2011, In : Cancer Cell. 20, 2, p. 246-259 14 p.

Research output: Contribution to journalArticle

172 Citations (Scopus)
2010

[Interleukin-2(IL-2) and its receptor].

Niiro, H., Jul 2010, In : Nippon rinsho. Japanese journal of clinical medicine. 68 Suppl 7, p. 69-71 3 p.

Research output: Contribution to journalArticle

[Interleukin-3(IL-3), IL-4, IL-5].

Niiro, H., Jul 2010, In : Nippon rinsho. Japanese journal of clinical medicine. 68 Suppl 7, p. 72-74 3 p.

Research output: Contribution to journalArticle

A critical role of c-Cbl-interacting protein of 85 kDa in the development and progression of head and neck squamous cell carcinomas through the Ras-ERK pathway

Wakasaki, T., Masuda, M., Niiro, H., Jabbarzadeh-Tabrizi, S., Noda, K., Taniyama, T., Komune, S. & Akashi, K., Oct 2010, In : Neoplasia. 12, 10, p. 789-796 8 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

CX3CL1 (fractalkine): A signpost for biliary inflammation in primary biliary cirrhosis

Shimoda, S., Harada, K., Niiro, H., Taketomi, A., Maehara, Y., Tsuneyama, K., Kikuchi, K., Nakanuma, Y., Mackay, I. R., Gershwin, M. E. & Akashi, K., Feb 1 2010, In : Hepatology. 51, 2, p. 567-575 9 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)

Gene expression profile of hyperoxic and hypoxic retinas in a mouse model of oxygen-induced retinopathy

Ishikawa, K., Yoshida, S., Kadota, K., Nakamura, T., Niiro, H., Arakawa, S., Yoshida, A., Akashi, K. & Ishibashi, T., Aug 1 2010, In : Investigative Ophthalmology and Visual Science. 51, 8, p. 4307-4319 13 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Safety and potential efficacy of tacrolimus for treatment of lupus nephritis with persistent proteinuria

Uchino, A., Tsukamoto, H., Nakashima, H., Yoshizawa, S., Furugo, I., Mitoma, H., Oryoji, K., Shimoda, T., Niiro, H., Tada, Y., Yano, T., Nonaka, T., Oishi, R., Akashi, K. & Horiuchi, T., Mar 23 2010, In : Clinical and experimental rheumatology. 28, 1, p. 6-12 7 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Wegener's granulomatosis detected initially by integrated 18F-fluorodeoxyglucose positron emission tomography/computed tomography

Ueda, N., Inoue, Y., Himeji, D., Shimao, Y., Oryoji, K., Mitoma, H., Arinobu, Y., Niiro, H., Tsukamoto, H., Horiuchi, T., Ueda, A. & Akashi, K., Apr 1 2010, In : Modern Rheumatology. 20, 2, p. 205-209 5 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)