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2019

Identification of candidate molecular targets of the novel antineoplastic antimitotic NP-10

Yokoyama, T., Yukuhiro, M., Iwasaki, Y., Tanaka, C., Sankoda, K., Fujiwara, R., Shibuta, A., Higashi, T., Motoyama, K., Arima, H., Yoshida, K., Sugimoto, N., Morimoto, H., Kosako, H., Ohshima, T. & Fujita, M., Dec 1 2019, In : Scientific reports. 9, 1, 16825.

Research output: Contribution to journalArticle

Open Access
Antimitotic Agents
Antineoplastic Agents
polyoxyethylene(10)nonylphenyl ether
Karyopherins
HCT116 Cells
2 Citations (Scopus)

Inhibiting the MCM8-9 complex selectively sensitizes cancer cells to cisplatin and olaparib

Morii, I., Iwabuchi, Y., Mori, S., Suekuni, M., Natsume, T., Yoshida, K., Sugimoto, N., Kanemaki, M. T. & Fujita, M., Mar 2019, In : Cancer Science. 110, 3, p. 1044-1053 10 p.

Research output: Contribution to journalArticle

Open Access
Cisplatin
Platinum Compounds
Neoplasms
Papillomaviridae
DNA Helicases
2018

Genome-wide analysis of the spatiotemporal regulation of firing and dormant replication origins in human cells

Sugimoto, N., Maehara, K., Yoshida, K., Ohkawa, Y. & Fujita, M., Jul 27 2018, In : Nucleic Acids Research. 46, 13, p. 6683-6696 14 p.

Research output: Contribution to journalArticle

Spatio-Temporal Analysis
Replication Origin
Chromatin
Transcription Initiation Site
Genome
13 Citations (Scopus)
Spatio-Temporal Analysis
Replication Origin
Chromatin
Transcription Initiation Site
Genome
3 Citations (Scopus)

GRWD1 regulates ribosomal protein L23 levels via the ubiquitin-proteasome system

Watanabe, S., Fujiyama, H., Takafuji, T., Kayama, K., Matsumoto, M., Nakayama, K. I., Yoshida, K., Sugimoto, N. & Fujita, M., Aug 1 2018, In : Journal of Cell Science. 131, 15

Research output: Contribution to journalArticle

Ribosomal Proteins
Proteasome Endopeptidase Complex
Ubiquitin
Glutamic Acid
Down-Regulation
5 Citations (Scopus)

Sensitive detection of fluorescence in western blotting by merging images

Kondo, Y., Higa, S., Iwasaki, T., Matsumoto, T., Maehara, K., Harada, A., Baba, Y., Fujita, M. & Ohkawa, Y., Jan 2018, In : PloS one. 13, 1, e0191532.

Research output: Contribution to journalArticle

Merging
Western blotting
Fluorescence
Western Blotting
fluorescence
2017
16 Citations (Scopus)

DNA replication origins and fork progression at mammalian telomeres

Higa, M., Fujita, M. & Yoshida, K., Apr 2017, In : Genes. 8, 4, 112.

Research output: Contribution to journalReview article

Replication Origin
Telomere
DNA Replication
Chromosomal Instability
Proteins
5 Citations (Scopus)

GRWD1, a new player among oncogenesis-related ribosomal/nucleolar proteins

Takafuji, T., Kayama, K., Sugimoto, N. & Fujita, M., Aug 3 2017, In : Cell Cycle. 16, 15, p. 1397-1403 7 p.

Research output: Contribution to journalReview article

Ribosomal Proteins
Nuclear Proteins
Carcinogenesis
Neoplasms
Protein Biosynthesis
13 Citations (Scopus)

GRWD1 negatively regulates p53 via the RPL11–MDM2 pathway and promotes tumorigenesis

Kayama, K., Watanabe, S., Takafuji, T., Tsuji, T., Hironaka, K., Matsumoto, M., Nakayama, K. I., Enari, M., Kohno, T., Shiraishi, K., Kiyono, T., Yoshida, K., Sugimoto, N. & Fujita, M., Jan 1 2017, In : EMBO Reports. 18, 1, p. 123-137 15 p.

Research output: Contribution to journalArticle

Glutamic Acid
Carcinogenesis
Ligases
Ubiquitin
WD40 Repeats
2 Citations (Scopus)

Molecular mechanism for chromatin regulation during MCM loading in mammalian cells

Sugimoto, N. & Fujita, M., Jan 1 2017, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 61-78 18 p. (Advances in Experimental Medicine and Biology; vol. 1042).

Research output: Chapter in Book/Report/Conference proceedingChapter

Multicarrier modulation
Chromatin
Nucleosomes
Licensure
Cells
8 Citations (Scopus)

Roles of the PDZ-binding motif of HPV 16 E6 protein in oncogenic transformation of human cervical keratinocytes

Yoshimatsu, Y., Nakahara, T., Tanaka, K., Inagawa, Y., Narisawa-Saito, M., Yugawa, T., Ohno, S. I., Fujita, M., Nakagama, H. & Kiyono, T., Jul 2017, In : Cancer Science. 108, 7, p. 1303-1309 7 p.

Research output: Contribution to journalArticle

PDZ Domains
Keratinocytes
Neoplastic Cell Transformation
Carcinogenesis
Proteins
5 Citations (Scopus)

TRF2 recruits ORC through TRFH domain dimerization

Higa, M., Kushiyama, T., Kurashige, S., Kohmon, D., Enokitani, K., Iwahori, S., Sugimoto, N., Yoshida, K. & Fujita, M., Jan 1 2017, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1864, 1, p. 191-201 11 p.

Research output: Contribution to journalArticle

Origin Recognition Complex
Dimerization
Telomere
DNA Replication
Chromatin
2016
3 Citations (Scopus)

Identification of immunoglobulin gene sequences from a small read number of mRNA-seq using hybridomas

Kuniyoshi, Y., Maehara, K., Iwasaki, T., Hayashi, M., Semba, Y., Fujita, M., Sato, Y., Kimura, H., Harada, A. & Ohkawa, Y., Oct 2016, In : PloS one. 11, 10, e0165473.

Research output: Contribution to journalArticle

immunoglobulin genes
Immunoglobulin Genes
hybridomas
Hybridomas
Immunoglobulins
4 Citations (Scopus)
Nucleosomes
Carrier Proteins
Replication Origin
Histones
Chromatin
2015
4 Citations (Scopus)

A novel anti-microtubule agent with carbazole and benzohydrazide structures suppresses tumor cell growth in vivo

Ohira, M., Iwasaki, Y., Tanaka, C., Kuroki, M., Matsuo, N., Kitamura, T., Yukuhiro, M., Morimoto, H., Pang, N., Liu, B., Kiyono, T., Amemiya, M., Tanaka, K., Yoshida, K., Sugimoto, N., Ohshima, T. & Fujita, M., May 19 2015, In : Biochimica et Biophysica Acta - General Subjects. 1850, 9, p. 1676-1684 9 p.

Research output: Contribution to journalArticle

Cell growth
Microtubules
Tumors
Cells
Growth
22 Citations (Scopus)

Cdt1-binding protein GRWD1 is a novel histone-binding protein that facilitates MCM loading through its influence on chromatin architecture

Sugimoto, N., Maehara, K., Yoshida, K., Yasukouchi, S., Osano, S., Watanabe, S., Aizawa, M., Yugawa, T., Kiyono, T., Kurumizaka, H., Ohkawa, Y. & Fujita, M., Jan 1 2015, In : Nucleic acids research. 43, 12, p. 5898-5911 14 p.

Research output: Contribution to journalArticle

Histones
Chromatin
Glutamic Acid
Carrier Proteins
Replication Origin
2013
30 Citations (Scopus)

Noncanonical NOTCH signaling limits self-renewal of human epithelial and induced pluripotent stem cells through ROCK activation

Yugawa, T., Nishino, K., Ohno, S. I., Nakahara, T., Fujita, M., Goshima, N., Umezawa, A. & Kiyono, T., Nov 15 2013, In : Molecular and cellular biology. 33, 22, p. 4434-4447 14 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Keratinocytes
Pluripotent Stem Cells
Critical Pathways
Monomeric GTP-Binding Proteins
2012
9 Citations (Scopus)

A critical role of MYC for transformation of human cells by HPV16 E6E7 and oncogenic HRAS

Narisawa-Saito, M., Inagawa, Y., Yoshimatsu, Y., Haga, K., Tanaka, K., Egawa, N., Ohno, S. I., Ichikawa, H., Yugawa, T., Fujita, M. & Kiyono, T., Apr 16 2012, In : Carcinogenesis. 33, 4, p. 910-917 8 p.

Research output: Contribution to journalArticle

Keratinocytes
Neoplastic Cell Transformation
Sirolimus
Neoplasms
Foreskin
26 Citations (Scopus)

Heterocomplex formation by Arp4 and β-actin is involved in the integrity of the Brg1 chromatin remodeling complex

Nishimoto, N., Watanabe, M., Watanabe, S., Sugimoto, N., Yugawa, T., Ikura, T., Koiwai, O., Kiyono, T. & Fujita, M., Aug 15 2012, In : Journal of Cell Science. 125, 16, p. 3870-3882 13 p.

Research output: Contribution to journalArticle

Chromatin Assembly and Disassembly
Actins
Histone Acetyltransferases
Proteins
Mutant Proteins
40 Citations (Scopus)

The E1 Protein of Human Papillomavirus Type 16 Is Dispensable for Maintenance Replication of the Viral Genome

Egawa, N., Nakahara, T., Ohno, S. I., Narisawa-Saito, M., Yugawa, T., Fujita, M., Yamato, K., Natori, Y. & Kiyono, T., Mar 1 2012, In : Journal of virology. 86, 6, p. 3276-3283 8 p.

Research output: Contribution to journalArticle

Papillomaviridae
Viral Genome
virus replication
Human papillomavirus 16
Maintenance
2011
26 Citations (Scopus)
Replication Origin
DNA Replication
Chromatin
Sucrose
DNA
2010
20 Citations (Scopus)

CDC6 interaction with ATR regulates activation of a replication checkpoint in higher eukaryotic cells

Yoshida, K., Sugimoto, N., Iwahori, S., Yugawa, T., Narisawa-Saito, M., Kiyono, T. & Fujita, M., Jan 15 2010, In : Journal of cell science. 123, 2, p. 225-235 11 p.

Research output: Contribution to journalArticle

Eukaryotic Cells
Xenopus
Phosphorylation
S Phase
Chromatin
38 Citations (Scopus)

ΔNp63α repression of the Notch1 gene supports the proliferative capacity of normal human keratinocytes and cervical cancer cells

Yugawa, T., Narisawa-Saito, M., Yoshimatsu, Y., Haga, K., Ohno, S. I., Egawa, N., Fujita, M. & Kiyono, T., May 15 2010, In : Cancer Research. 70, 10, p. 4034-4044 11 p.

Research output: Contribution to journalArticle

Keratinocytes
Uterine Cervical Neoplasms
Genes
Differentiation Antigens
p53 Genes