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2015
13 Citations (Scopus)

Necklace cytoplasmic bodies in hereditary myopathy with early respiratory failure

Uruha, A., Hayashi, Y. K., Oya, Y., Mori-Yoshimura, M., Kanai, M., Murata, M., Kawamura, M., Ogata, K., Matsumura, T., Suzuki, S., Takahashi, Y., Kondo, T., Kawarabayashi, T., Ishii, Y., Kokubun, N., Yokoi, S., Yasuda, R., Kira, J. I., Mitsuhashi, S., Noguchi, S. & 2 others, Nonaka, I. & Nishino, I., May 1 2015, In : Journal of Neurology, Neurosurgery and Psychiatry. 86, 5, p. 483-489 7 p.

Research output: Contribution to journalArticle

Fibronectins
Muscles
Pathology
Sensitivity and Specificity
Muscular Diseases

Neuropathology of multiple sclerosis

Masaki, K. & Kira, J. I., Sep 1 2015, In : Nihon rinsho. Japanese journal of clinical medicine. 73, p. 141-149 9 p.

Research output: Contribution to journalArticle

Acute Disease
Meningitis
Multiple Sclerosis
Disease Progression
Chronic Disease
5 Citations (Scopus)

Outcomes of pregnancy during interferon beta-1a therapy in Japanese patients with multiple sclerosis: Interim results of a postmarketing surveillance study

Shimizu, Y., Makioka, H., Harada, N., Nakabayashi, S., Saida, T. & Kira, J-I., Nov 1 2015, In : Clinical and Experimental Neuroimmunology. 6, 4, p. 402-408 7 p.

Research output: Contribution to journalArticle

Pregnancy Outcome
Multiple Sclerosis
Recurrence
Postpartum Period
Pregnancy
Central Nervous System Diseases
Demyelinating Diseases
Peripheral Nervous System Diseases
Multiple Sclerosis
Pathology
39 Citations (Scopus)

Peripheral blood T cell dynamics predict relapse in multiple sclerosis patients on fingolimod

Song, Z. Y., Yamasaki, R., Kawano, Y., Sato, S., Masaki, K., Yoshimura, S., Matsuse, D., Murai, H., Matsushita, T. & Kira, J. I., Apr 28 2015, In : PloS one. 10, 4, e0124923.

Research output: Contribution to journalArticle

T-cells
relapse
sclerosis
blood cells
Multiple Sclerosis
20 Citations (Scopus)

Pre-admission CHADS2, CHA2DS2-VASc, and R2CHADS2 scores on severity and functional outcome in acute ischemic stroke with atrial fibrillation

Tanaka, K., Yamada, T., Torii, T., Furuta, K., Matsumoto, S., Yoshimura, T., Takase, K. I., Wakata, Y., Nakashima, N., Kira, J. I. & Murai, H., Jul 1 2015, In : Journal of Stroke and Cerebrovascular Diseases. 24, 7, p. 1629-1635 7 p.

Research output: Contribution to journalArticle

Atrial Fibrillation
Stroke
ROC Curve
National Institutes of Health (U.S.)
Area Under Curve
2 Citations (Scopus)

Pure dysarthria and dysarthria-facial paresis syndrome due to internal capsule and/or corona radiata infarction

Tanaka, K., Yamada, T., Torii, T., Yoshimura, T., Takase, K. I., Togao, O., Wakata, Y., Hiwatashi, A., Nakashima, N., Kira, J. I. & Murai, H., Oct 7 2015, In : BMC neurology. 15, 1, 184.

Research output: Contribution to journalArticle

Internal Capsule
Dysarthria
Facial Paralysis
Infarction
Stroke

Tumefactive multiple sclerosis and connexin

Masaki, K. & Kira, J. I., Sep 1 2015, In : Nihon rinsho. Japanese journal of clinical medicine. 73, p. 826-834 9 p.

Research output: Contribution to journalArticle

Connexins
Gap Junctions
Cell Communication
Neuroglia
Multiple Sclerosis
2014
2 Citations (Scopus)

[Disease concept, etiology and mechanisms of multiple sclerosis]

Kira, J. I., Nov 1 2014, In : Nihon rinsho. Japanese journal of clinical medicine. 72, 11, p. 1884-1894 11 p.

Research output: Contribution to journalReview article

Multiple Sclerosis
Central Nervous System
Genes
Th17 Cells
Th1 Cells

[Genetic factors in multiple sclerosis and neuromyelitis optica]

Sato, S. & Kira, J. I., Nov 1 2014, In : Nihon rinsho. Japanese journal of clinical medicine. 72, 11, p. 1918-1923 6 p.

Research output: Contribution to journalArticle

Neuromyelitis Optica
Multiple Sclerosis
Disease Resistance
Genome-Wide Association Study
Major Histocompatibility Complex
2 Citations (Scopus)

A case of adult-onset reducing body myopathy presenting a novel clinical feature, asymmetrical involvement of the sternocleidomastoid and trapezius muscles

Fujii, T., Hayashi, S., Kawamura, N., Higuchi, M. A., Tsugawa, J., Ohyagi, Y., Hayashi, Y. K., Nishino, I. & Kira, J. I., Aug 15 2014, In : Journal of the Neurological Sciences. 343, 1-2, p. 206-210 5 p.

Research output: Contribution to journalArticle

Superficial Back Muscles
Muscular Diseases
Muscles
Atrophy
Mutation
8 Citations (Scopus)

A case of neuromyelitis optica harboring both anti-aquaporin-4 antibodies and a pathogenic mitochondrial DNA mutation for Leber's hereditary optic neuropathy

Shiraishi, W., Hayashi, S., Kamada, T., Isobe, N., Yamasaki, R., Murai, H., Ohyagi, Y. & Kira, J. I., Feb 1 2014, In : Multiple Sclerosis. 20, 2, p. 258-260 3 p.

Research output: Contribution to journalArticle

Leber's Hereditary Optic Atrophy
Aquaporin 4
Neuromyelitis Optica
Optic Nerve
Mitochondrial DNA
1 Citation (Scopus)

A case of non-convulsive status epilepticus after influenza virus B infection

Une, H., Uehara, T., Tateishi, T., Shigetou, H., Oyagi, Y. & Kira, J. I., Mar 2014, In : Clinical Neurology. 54, 3, p. 227-230 4 p.

Research output: Contribution to journalArticle

Status Epilepticus
Virus Diseases
Orthomyxoviridae
Consciousness
etiracetam
15 Citations (Scopus)

Age-related changes across the primary and secondary somatosensory areas: An analysis of neuromagnetic oscillatory activities

Hagiwara, K., Ogata, K., Okamoto, T., Uehara, T., Hironaga, N., Shigeto, H., Kira, J. I. & Tobimatsu, S., May 2014, In : Clinical Neurophysiology. 125, 5, p. 1021-1029 9 p.

Research output: Contribution to journalArticle

Somatosensory Cortex
Magnetic Fields
Magnetoencephalography
Somatosensory Evoked Potentials
Median Nerve
68 Citations (Scopus)

A nationwide survey of hypertrophic pachymeningitis in Japan

Yonekawa, T., Murai, H., Utsuki, S., Matsushita, T., Masaki, K., Isobe, N., Yamasaki, R., Yoshida, M., Kusunoki, S., Sakata, K., Fujii, K. & Kira, J. I., Jul 2014, In : Journal of Neurology, Neurosurgery and Psychiatry. 85, 7, p. 732-739 8 p.

Research output: Contribution to journalArticle

Meningitis
Japan
Antineutrophil Cytoplasmic Antibodies
Immunoglobulin G
Surveys and Questionnaires
39 Citations (Scopus)

Apathy/depression, but not subjective fatigue, is related with cognitive dysfunction in patients with multiple sclerosis

Niino, M., Mifune, N., Kohriyama, T., Mori, M., Ohashi, T., Kawachi, I., Shimizu, Y., Fukaura, H., Nakashima, I., Kusunoki, S., Miyamoto, K., Yoshida, K., Kanda, T., Nomura, K., Yamamura, T., Yoshii, F., Kira, J. I., Nakane, S., Yokoyama, K., Matsui, M. & 2 others, Miyazaki, Y. & Kikuchi, S., Jan 6 2014, In : BMC neurology. 14, 1, 3.

Research output: Contribution to journalArticle

Apathy
Multiple Sclerosis
Fatigue
Cognition
Depression
6 Citations (Scopus)

Association of cognitive impairment with magnetic resonance imaging findings and social activities in patients with multiple sclerosis

Niino, M., Mifune, N., Kohriyama, T., Mori, M., Ohashi, T., Kawachi, I., Shimizu, Y., Fukaura, H., Nakashima, I., Kusunoki, S., Miyamoto, K., Yoshida, K., Kanda, T., Nomura, K., Yamamura, T., Yoshii, F., Kira, J. I., Nakane, S., Yokoyama, K., Matsui, M. & 2 others, Miyazaki, Y. & Kikuchi, S., Oct 1 2014, In : Clinical and Experimental Neuroimmunology. 5, 3, p. 328-335 8 p.

Research output: Contribution to journalArticle

Multiple Sclerosis
Magnetic Resonance Imaging
Neuropsychological Tests
Brain Stem
Cognition
21 Citations (Scopus)

Clinical features and treatment status of adult myasthenia gravis in Japan

Murai, H., Masuda, M., Utsugisawa, K., Nagane, Y., Suzuki, S., Imai, T., Motomura, M., Konno, S. & Kira, J. I., Feb 2014, In : Clinical and Experimental Neuroimmunology. 5, 1, p. 84-91 8 p.

Research output: Contribution to journalArticle

Myasthenia Gravis
Thymoma
Japan
Therapeutics
Age of Onset
20 Citations (Scopus)

Corpus callosum atrophy in patients with hereditary diffuse leukoencephalopathy with neuroaxonal spheroids: An MRI-based study

Kinoshita, M., Kondo, Y., Yoshida, K., Fukushima, K., Hoshi, K. I., Ishizawa, K., Araki, N., Yazawa, I., Washimi, Y., Saitoh, B., Kira, J. I. & Ikeda, S. I., Jan 1 2014, In : Internal Medicine. 53, 1, p. 21-27 7 p.

Research output: Contribution to journalArticle

Corpus Callosum
Atrophy
Nervous System
Magnetic Resonance Imaging
Leukoencephalopathies
2 Citations (Scopus)

Decreased CCR2 and CD62L expressions on peripheral blood classical monocytes in amyotrophic lateral sclerosis

Cui, Y. W., Kawano, Y., Yamasaki, R., Shi, N., Masaki, K., Isobe, N., Yonekawa, T., Matsushita, T., Tateishi, T., Hayashi, S. & Kira, J-I., Jan 1 2014, In : Clinical and Experimental Neuroimmunology. 5, 1, p. 92-96 5 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Monocytes
Chemotaxis
Immune System
Flow Cytometry
3 Citations (Scopus)

Distinct cytokine and T helper cell profiles between patients with multiple sclerosis who had or had not received interferon-beta

Doi, H., Song, Z. Y., Yoshimura, S., Tateishi, T., Yonekawa, T., Yamasaki, R., Murai, H., Matsushita, T. & Kira, J. I., Oct 1 2014, In : Clinical and Experimental Neuroimmunology. 5, 3, p. 321-327 7 p.

Research output: Contribution to journalArticle

Interferon-beta
Helper-Inducer T-Lymphocytes
Interferons
Multiple Sclerosis
Cytokines
1 Citation (Scopus)

Early inhibition of tumor necrosis factor-α and interleukin-6 in muscle tissue as a therapy for dystrophinopathy in mdx mice

Arahata, H., Ohyagi, Y., Iinuma, K. M., Tanaka, M., Tateishi, T., Yamasaki, R., Matsushita, T. & Kira, J. I., Oct 1 2014, In : Clinical and Experimental Neuroimmunology. 5, 3, p. 371-377 7 p.

Research output: Contribution to journalArticle

Inbred mdx Mouse
Interleukin-6
Tumor Necrosis Factor-alpha
Cytokines
Muscles
72 Citations (Scopus)

Efficiency of a small-world brain network depends on consciousness level: A resting-state fMRI study

Uehara, T., Yamasaki, T., Okamoto, T., Koike, T., Kan, S., Miyauchi, S., Kira, J. I. & Tobimatsu, S., Jun 2014, In : Cerebral Cortex. 24, 6, p. 1529-1539 11 p.

Research output: Contribution to journalArticle

Consciousness
Magnetic Resonance Imaging
Brain
Sleep Stages
Communication
1 Citation (Scopus)

Epilepsy and functional brain networks

Uehara, T., Shigeto, H. & Kira, J-I., Jan 1 2014, In : Clinical Neurology. 54, 12, p. 1139-1141 3 p.

Research output: Contribution to journalArticle

Epilepsy
Brain
Partial Epilepsy
Stroke
Magnetic Resonance Imaging
1 Citation (Scopus)
Drugs
Efficacy
Multiple Sclerosis
Multiple Sclerosis
Pharmaceutical Preparations
28 Citations (Scopus)

Extensive dysregulations of oligodendrocytic and astrocytic connexins are associated with disease progression in an amyotrophic lateral sclerosis mouse model

Cui, Y., Masaki, K., Yamasaki, R., Imamura, S., Suzuki, S. O., Hayashi, S., Sato, S., Nagara, Y., Kawamura, M. F. & Kira, J. I., Mar 6 2014, In : Journal of neuroinflammation. 11, 42.

Research output: Contribution to journalArticle

Connexins
Amyotrophic Lateral Sclerosis
Disease Progression
Horns
Excitatory Amino Acid Transporter 2
34 Citations (Scopus)

Fingolimod (FTY720) therapy in Japanese patients with relapsing multiple sclerosis over 12 months: Results of a phase 2 observational extension

Kira, J. I., Itoyama, Y., Kikuchi, S., Hao, Q., Kurosawa, T., Nagato, K., Tsumiyama, I., von Rosenstiel, P., Zhang-Auberson, L. & Saida, T., Jan 29 2014, In : BMC neurology. 14, 1, 21.

Research output: Contribution to journalArticle

Multiple Sclerosis
Aquaporin 4
Therapeutics
Safety
Placebos
Meningitis
Japan
Surveys and Questionnaires
8 Citations (Scopus)

Genetic and infectious profiles influence cerebrospinal fluid IgG abnormality in japanese multiple sclerosis patients

Yoshimura, S., Isobe, N., Matsushita, T., Masaki, K., Sato, S., Kawano, Y., Ochi, H. & Kira, J. I., Apr 15 2014, In : PloS one. 9, 4, e95367.

Research output: Contribution to journalArticle

Open Access
Cerebrospinal fluid
sclerosis
cerebrospinal fluid
Multiple Sclerosis
Cerebrospinal Fluid
12 Citations (Scopus)

Genetic and infectious profiles influence cerebrospinal fluid IgG abnormality in Japanese multiple sclerosis patients

Yoshimura, S., Isobe, N., Matsushita, T., Masaki, K., Sato, S., Kawano, Y., Ochi, H. & Kira, J. I., Jan 1 2014, In : PloS one. 9, 4, p. e95367

Research output: Contribution to journalArticle

Open Access
Cerebrospinal fluid
sclerosis
cerebrospinal fluid
Multiple Sclerosis
Cerebrospinal Fluid
11 Citations (Scopus)

Interleukin 2 receptor α chain gene polymorphisms and risks of multiple sclerosis and neuromyelitis optica in southern Japanese

Ainiding, G., Kawano, Y., Sato, S., Isobe, N., Matsushita, T., Yoshimura, S., Yonekawa, T., Yamasaki, R., Murai, H. & Kira, J. I., Feb 15 2014, In : Journal of the Neurological Sciences. 337, 1-2, p. 147-150 4 p.

Research output: Contribution to journalArticle

Neuromyelitis Optica
Interleukin-2 Receptors
Multiple Sclerosis
Genes
Genotype
3 Citations (Scopus)

Japanese guidelines for fingolimod in multiple sclerosis: Putting into practice

Matsui, M., Shimizu, Y., Doi, H., Tomioka, R., Nakashima, I., Niino, M. & Kira, J-I., Jan 1 2014, In : Clinical and Experimental Neuroimmunology. 5, 1, p. 34-48 15 p.

Research output: Contribution to journalReview article

Multiple Sclerosis
Guidelines
Lysosphingolipid Receptors
Aquaporin 4
Neuromyelitis Optica
Neurosciences
Allergy and Immunology
Myelitis
Multiple Sclerosis
Hyperalgesia
Multiple Sclerosis
Japan
Research

The actual state and problems in neurology training at graduate school

Kira, J-I., Ohyagi, Y., Taniwaki, T., Inuzuka, T., Yoshii, F., Aoki, M., Amano, T., Toyoshima, I., Fukutake, T. & Hashimoto, Y., Jan 1 2014, In : Clinical Neurology. 54, 4, p. 349-358 10 p.

Research output: Contribution to journalArticle

Neurology
Students
Japan
Research
Education

The actual state and problems in neurology training at hospital

Fukutake, T., Hashimoto, Y., Taniwaki, T., Toyoshima, I., Amano, T., Aoki, M., Yoshii, F., Inuzuka, T. & Kira, J-I., Jan 1 2014, In : Clinical Neurology. 54, 4, p. 341-348 8 p.

Research output: Contribution to journalArticle

Neurology
Teaching
Certification
Teaching Hospitals
Education

The actual state and problems in neurology training in medical schools

Taniwaki, T., Inuzuka, T., Yoshii, F., Aoki, M., Amano, T., Toyoshima, I., Fukutake, T., Hashimoto, Y. & Kira, J. I., 2014, In : Clinical Neurology. 54, 4, p. 335-340 6 p.

Research output: Contribution to journalArticle

Neurology
Medical Schools
Education
Graduate Education
Textbooks
Multiple Sclerosis
Fingolimod Hydrochloride
Multiple Sclerosis
Central Nervous System
Lysosphingolipid Receptors
Lymphocytes
Spinal Cord
2013

[Susceptible and resistant factors in neuro-immune disease].

Sato, S. & Kira, J. I., May 2013, In : Unknown Journal. 71, 5, p. 783-788 6 p.

Research output: Contribution to journalReview article

Immune System Diseases
Genetic Research
Microbiology
Allergy and Immunology
Biochemistry
26 Citations (Scopus)

A case of hereditary diffuse leukoencephalopathy with axonal spheroids caused by a de novo mutation in CSF1R masquerading as primary progressive multiple sclerosis

Saitoh, B. Y., Yamasaki, R., Hayashi, S., Yoshimura, S., Tateishi, T., Ohyagi, Y., Murai, H., Iwaki, T., Yoshida, K. & Kira, J. I., Sep 2013, In : Multiple Sclerosis Journal. 19, 10, p. 1367-1370 4 p.

Research output: Contribution to journalArticle

Colony-Stimulating Factor Receptors
Chronic Progressive Multiple Sclerosis
Macrophage Colony-Stimulating Factor
Neurologic Gait Disorders
Dysarthria
4 Citations (Scopus)

A case of medulla oblongata compression by tortuous vertebral arteries presenting with spastic quadriplegia

Kamada, T., Tateishi, T., Yamashita, T., Nagata, S., Ohyagi, Y. & Kira, J. I., Jan 1 2013, In : Clinical Neurology. 53, 5, p. 356-361 6 p.

Research output: Contribution to journalArticle

Medulla Oblongata
Quadriplegia
Vertebral Artery
Spastic Paraparesis
Lower Extremity
3 Citations (Scopus)

A case of neuromyelitis optica spectrum disorder associated with a limited cutaneous systemic sclerosis and Sjögren syndrome

Iwanaga, Y., Hayashi, S., Kawamura, N., Ohyagi, Y. & Kira, J. I., Sep 1 2013, In : Clinical Neurology. 53, 9, p. 695-700 6 p.

Research output: Contribution to journalArticle

Neuromyelitis Optica
Systemic Scleroderma
Skin
Paraparesis
Lower Extremity
2 Citations (Scopus)

A case of sensory ataxic neuropathy, dysarthria, and ophthalmoparesis with multiple mitochondrial DNA deletions

Tanaka, K., Tateishi, T., Kawamura, N., Ohyagi, Y., Urata, M. & Kira, J. I., Mar 1 2013, In : Clinical Neurology. 53, 3, p. 205-211 7 p.

Research output: Contribution to journalArticle

Muscle Weakness
Mitochondrial DNA
Exons
Lactic Acid
Sural Nerve
7 Citations (Scopus)

A guide to facilitate the early treatment of patients with idiopathic demyelinating disease (multiple sclerosis and neuromyelitis optica)

Carroll, W. M., Saida, T., Kim, H. J., Kira, J., Kermode, A. G., Tsai, C. P., Fujihara, K., Kusunoki, S., Tanaka, M., Kim, K. K. & Bates, D., Sep 2013, In : Multiple Sclerosis Journal. 19, 10, p. 1371-1380 10 p.

Research output: Contribution to journalReview article

Neuromyelitis Optica
Demyelinating Diseases
Multiple Sclerosis
Therapeutics
Neurology