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  • Noriko Isobe
2020

A case of overlapping adult-onset linear scleroderma and Parry-Romberg syndrome presenting with widespread ipsilateral neurogenic involvement

Yamasaki, R., Yonekawa, T., Inamizu, S., Shinoda, K., Ochi, H., Matsushita, T., Isobe, N., Tsuji, G., Sadashima, S., Kuma, Y., Oda, Y., Iwaki, T., Furue, M. & Kira, J. I., Feb 1 2020, In : Neuropathology. 40, 1, p. 109-115 7 p.

Research output: Contribution to journalArticle

Central nervous system-specific antinuclear antibodies in patients with multiple sclerosis

Fujii, T., Yamasaki, R., Miyachi, Y., Nagata, S., Maimaitijiang, G., Nakamura, Y., Shinoda, K., Matsushita, T., Isobe, N. & Kira, J. I., Feb 15 2020, In : Journal of the Neurological Sciences. 409, 116619.

Research output: Contribution to journalArticle

Environmental risk factors for multiple sclerosis in Japanese people

Sakoda, A., Matsushita, T., Nakamura, Y., Watanabe, M., Shinoda, K., Masaki, K., Isobe, N., Yamasaki, R. & Kira, J. I., Feb 2020, In : Multiple Sclerosis and Related Disorders. 38, 101872.

Research output: Contribution to journalArticle

Oligodendroglial connexin 47 regulates neuroinflammation upon autoimmune demyelination in a novel mouse model of multiple sclerosis

Zhao, Y., Yamasaki, R., Yamaguchi, H., Nagata, S., Une, H., Cui, Y., Masaki, K., Nakamuta, Y., Iinuma, K., Watanabe, M., Matsushita, T., Isobe, N. & Kira, J. I., Jan 28 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 4, p. 2160-2169 10 p.

Research output: Contribution to journalArticle

Spinal cord involvement by atrophy and associations with disability are different between multiple sclerosis and neuromyelitis optica spectrum disorder

Nakamura, Y., Liu, Z., Fukumoto, S., Shinoda, K., Sakoda, A., Matsushita, T., Hayashida, S., Isobe, N., Watanabe, M., Hiwatashi, A., Yamasaki, R. & Kira, J. I., Jan 1 2020, In : European Journal of Neurology. 27, 1, p. 92-99 8 p.

Research output: Contribution to journalArticle

Unique HLA haplotype associations in IgG4 anti-neurofascin 155 antibody-positive chronic inflammatory demyelinating polyneuropathy

Ogata, H., Isobe, N., Zhang, X., Yamasaki, R., Fujii, T., Machida, A., Morimoto, N., Kaida, K., Masuda, T., Ando, Y., Kuwahara, M., Kusunoki, S., Nakamura, Y., Matsushita, T. & Kira, J. I., Feb 15 2020, In : Journal of Neuroimmunology. 339, 577139.

Research output: Contribution to journalArticle

2019

A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis

International Multiple Sclerosis Genetics Consortium, Dec 1 2019, In : Nature communications. 10, 1, 2236.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)
Open Access

Brainstem posterior reversible encephalopathy syndrome in a case with Guillain–Barré syndrome

Yokoyama, J., Yamaguchi, H., Koge, J., Matsushita, T., Isobe, N., Yamasaki, R. & Kira, J. I., Nov 1 2019, In : Clinical and Experimental Neuroimmunology. 10, 4, p. 267-271 5 p.

Research output: Contribution to journalArticle

Case of central nervous system inflammatory disease in late pregnancy

Isobe, N., Baba, T., Nakamura, Y., Shinoda, K., Watanabe, M., Matsushita, T. & Kira, J. I., Mar 2019, In : Clinical and Experimental Neuroimmunology. 10, S1, p. 54-58 5 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Helicobacter pylori infection and demyelinating disease of the central nervous system

Kira, J. I. & Isobe, N., Apr 15 2019, In : Journal of Neuroimmunology. 329, p. 14-19 6 p.

Research output: Contribution to journalReview article

3 Citations (Scopus)

Intractable axonal neuropathy with multifocal peripheral nerve swelling in neuromyelitis optica spectrum disorders: A case report

Mizuno, Y., Shinoda, K., Watanabe, M., Ogata, H., Isobe, N., Matsushita, T., Yamasaki, R., Tanaka, K., Koike, H., Katsuno, M. & Kira, J. I., Oct 2019, In : Multiple Sclerosis and Related Disorders. 35, p. 16-18 3 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Intrathecal cytokine profile in neuropathy with anti-neurofascin 155 antibody

Ogata, H., Zhang, X., Yamasaki, R., Fujii, T., Machida, A., Morimoto, N., Kaida, K., Masuda, T., Ando, Y., Kuwahara, M., Kusunoki, S., Nakamura, Y., Matsushita, T., Isobe, N. & Kira, J. I., Nov 1 2019, In : Annals of Clinical and Translational Neurology. 6, 11, p. 2304-2316 13 p.

Research output: Contribution to journalArticle

Open Access

Link between HLA alleles and anti-NMDAR encephalitis

Isobe, N., Jun 1 2019, In : Journal of Neurology, Neurosurgery and Psychiatry. 90, 6, 1 p.

Research output: Contribution to journalComment/debate

Long-term use of interferon-β in multiple sclerosis increases Vδ1-Vδ2-Vγ9- γδ T cells that are associated with a better outcome

Maimaitijiang, G., Watanabe, M., Shinoda, K., Isobe, N., Nakamura, Y., Masaki, K., Matsushita, T., Yoshikai, Y. & Kira, J. I., Sep 13 2019, In : Journal of neuroinflammation. 16, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

International Multiple Sclerosis Genetics Consortium & ANZgene, IIBDGC, WTCCC2, Sep 27 2019, In : Science. 365, 6460, eaav7188.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Recurrent rhombencephalomyelitis associated with allergen immunotherapy by mite antigen sublingual tablets

Kawajiri, M., Koge, J., Hashimoto, T., Yamada, T., Isobe, N. & Kira, J. I., Jun 2019, In : eNeurologicalSci. 15, 100190.

Research output: Contribution to journalLetter

Open Access

Serum GFAP and neurofilament light as biomarkers of disease activity and disability in NMOSD

Watanabe, M., Nakamura, Y., Michalak, Z., Isobe, N., Barro, C., Leppert, D., Matsushita, T., Hayashi, F., Yamasaki, R., Kuhle, J. & Kira, J. I., Sep 24 2019, In : Neurology. 93, 13, p. E1299-E1311

Research output: Contribution to journalArticle

2 Citations (Scopus)

Sex-specific Tau methylation patterns and synaptic transcriptional alterations are associated with neural vulnerability during chronic neuroinflammation

Didonna, A., Cantó, E., Shams, H., Isobe, N., Zhao, C., Caillier, S. J., Condello, C., Yamate-Morgan, H., Tiwari-Woodruff, S. K., Mofrad, M. R. K., Hauser, S. L. & Oksenberg, J. R., Jul 2019, In : Journal of Autoimmunity. 101, p. 56-69 14 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

The genetic diversity of multiple sclerosis risk among Hispanic and African American populations living in the United States

Beecham, A. H., Amezcua, L., Chinea, A., Manrique, C. P., Rubi, C., Isobe, N., Lund, B. T., Santaniello, A., Beecham, G. W., Burchard, E. G., Comabella, M., Patsopoulos, N., Fitzgerald, K., Calabresi, P. A., De Jager, P., Conti, D. V., Delgado, S. R., Oksenberg, J. R. & McCauley, J. L., Jan 1 2019, (Accepted/In press) In : Multiple Sclerosis Journal.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2018

Aberrant STAT phosphorylation signaling in peripheral blood mononuclear cells from multiple sclerosis patients

MS-EPIC Study Group, Mar 7 2018, In : Journal of neuroinflammation. 15, 1, 72.

Research output: Contribution to journalArticle

4 Citations (Scopus)

A comparison of brain magnetic resonance imaging lesions in multiple sclerosis by race with reference to disability progression

Nakamura, Y., Gaetano, L., Matsushita, T., Anna, A., Sprenger, T., Radue, E. W., Wuerfel, J., Bauer, L., Amann, M., Shinoda, K., Isobe, N., Yamasaki, R., Saida, T., Kappos, L. & Kira, J. I., Sep 5 2018, In : Journal of neuroinflammation. 15, 1, 255.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Association of decreased percentage of Vδ2+Vγ9+ γδ T cells with disease severity in multiple sclerosis

Maimaitijiang, G., Shinoda, K., Nakamura, Y., Masaki, K., Matsushita, T., Isobe, N., Yamasaki, R., Yoshikai, Y. & Kira, J. I., Apr 10 2018, In : Frontiers in Immunology. 9, APR, 748.

Research output: Contribution to journalArticle

2 Citations (Scopus)
6 Citations (Scopus)

Emerging importance of big data in neuroimmunological research

Isobe, N., Feb 1 2018, In : Clinical and Experimental Neuroimmunology. 9, 1, 1 p.

Research output: Contribution to journalEditorial

Genetics in multiple sclerosis: Updates in the era of big data

Isobe, N., Feb 1 2018, In : Clinical and Experimental Neuroimmunology. 9, 1, p. 19-24 6 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)

Oral phase dysphagia in facial onset sensory and motor neuronopathy

Watanabe, M., Shiraishi, W., Yamasaki, R., Isobe, N., Sawatsubashi, M., Yasumatsu, R., Nakagawa, T. & Kira, J. I., Jun 2018, In : Brain and Behavior. 8, 6, e00999.

Research output: Contribution to journalArticle

多地点接続症例検討遠隔会議におけるユーザー体感品質を考慮した技術的課題 (JTTA 2018 FUKUOKA 第22回日本遠隔医療学会学術大会)

Translated title of the contribution: Technical agenda considering QoE in large multiparty videoconferencing for clinical case study富松俊太, 工藤孔梨子, 森山智彦, 平井康之, 磯部紀子 & 清水周次, Oct 2018, In : 日本遠隔医療学会雑誌 = Japanese journal of telemedicine and telecare. 14, 2, p. 155-158 4 p.

Research output: Contribution to journalArticle

2017

American Academy of Neurology 2017 Annual Meeting

Isobe, N., Aug 2017, In : Clinical and Experimental Neuroimmunology. 8, 3, p. 273-275 3 p.

Research output: Contribution to journalArticle

2016

Association of HLA genetic risk burden with disease phenotypes in multiple sclerosis

Isobe, N., Keshavan, A., Gourraud, P. A., Zhu, A. H., Datta, E., Schlaeger, R., Caillier, S. J., Santaniello, A., Lizée, A., Himmelstein, D. S., Baranzini, S. E., Hollenbach, J., Cree, B. A. C., Hauser, S. L., Oksenberg, J. R. & Henry, R. G., Jul 2016, In : JAMA Neurology. 73, 7, p. 795-802 8 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

HLA genetic risk burden in multiple sclerosis-reply

Isobe, N., Oksenberg, J. R. & Henry, R. G., Jan 1 2016, In : JAMA Neurology. 73, 12, p. 1501-1502 2 p.

Research output: Contribution to journalLetter

Latitude and HLA-DRB1*04:05 independently influence disease severity in Japanese multiple sclerosis: A cross-sectional study

Nakamura, Y., Matsushita, T., Sato, S., Niino, M., Fukazawa, T., Yoshimura, S., Hisahara, S., Isobe, N., Shimohama, S., Watanabe, M., Yoshida, K., Houzen, H., Miyazaki, Y., Yamasaki, R., Kikuchi, S. & Kira, J. I., Sep 6 2016, In : Journal of neuroinflammation. 13, 1, 239.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2014

A case of neuromyelitis optica harboring both anti-aquaporin-4 antibodies and a pathogenic mitochondrial DNA mutation for Leber's hereditary optic neuropathy

Shiraishi, W., Hayashi, S., Kamada, T., Isobe, N., Yamasaki, R., Murai, H., Ohyagi, Y. & Kira, J. I., Feb 1 2014, In : Multiple Sclerosis. 20, 2, p. 258-260 3 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

A nationwide survey of hypertrophic pachymeningitis in Japan

Yonekawa, T., Murai, H., Utsuki, S., Matsushita, T., Masaki, K., Isobe, N., Yamasaki, R., Yoshida, M., Kusunoki, S., Sakata, K., Fujii, K. & Kira, J. I., Jul 2014, In : Journal of Neurology, Neurosurgery and Psychiatry. 85, 7, p. 732-739 8 p.

Research output: Contribution to journalArticle

72 Citations (Scopus)

Decreased CCR2 and CD62L expressions on peripheral blood classical monocytes in amyotrophic lateral sclerosis

Cui, Y. W., Kawano, Y., Yamasaki, R., Shi, N., Masaki, K., Isobe, N., Yonekawa, T., Matsushita, T., Tateishi, T., Hayashi, S. & Kira, J-I., Jan 1 2014, In : Clinical and Experimental Neuroimmunology. 5, 1, p. 92-96 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Genetic and infectious profiles influence cerebrospinal fluid IgG abnormality in japanese multiple sclerosis patients

Yoshimura, S., Isobe, N., Matsushita, T., Masaki, K., Sato, S., Kawano, Y., Ochi, H. & Kira, J. I., Apr 15 2014, In : PloS one. 9, 4, e95367.

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)

Genetic and infectious profiles influence cerebrospinal fluid IgG abnormality in Japanese multiple sclerosis patients

Yoshimura, S., Isobe, N., Matsushita, T., Masaki, K., Sato, S., Kawano, Y., Ochi, H. & Kira, J. I., Jan 1 2014, In : PloS one. 9, 4, p. e95367

Research output: Contribution to journalArticle

Open Access
12 Citations (Scopus)
3 Citations (Scopus)

Interleukin 2 receptor α chain gene polymorphisms and risks of multiple sclerosis and neuromyelitis optica in southern Japanese

Ainiding, G., Kawano, Y., Sato, S., Isobe, N., Matsushita, T., Yoshimura, S., Yonekawa, T., Yamasaki, R., Murai, H. & Kira, J. I., Feb 15 2014, In : Journal of the Neurological Sciences. 337, 1-2, p. 147-150 4 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Oligoclonal bands and age at onset correlate with genetic risk score in multiple sclerosis

Harbo, H. F., Isobe, N., Berg-Hansen, P., Bos, S. D., Caillier, S. J., Gustavsen, M. W., Mero, I. L., Celius, E. G., Hauser, S. L., Oksenberg, J. R. & Gourraud, P. A., May 2014, In : Multiple Sclerosis Journal. 20, 6, p. 660-668 9 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)
2013

Alterations in chemokine receptor expressions on peripheral blood monocytes in multiple sclerosis and neuromyelitis optica

Cui, Y. W., Kawano, Y., Shi, N., Masaki, K., Isobe, N., Yonekawa, T., Matsushita, T., Tateishi, T., Yamasaki, R., Murai, H. & Kira, J. I., Aug 1 2013, In : Clinical and Experimental Neuroimmunology. 4, 2, p. 201-205 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

A NOTCH4 missense mutation confers resistance to multiple sclerosis in Japanese

Huang, J., Yoshimura, S., Isobe, N., Matsushita, T., Yonekawa, T., Sato, S., Yamasaki, R. & Kira, J. I., Nov 2013, In : Multiple Sclerosis Journal. 19, 13, p. 1696-1703 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2 Citations (Scopus)
101 Citations (Scopus)

Clinical relevance of serum aquaporin-4 antibody levels in neuromyelitis optica

Isobe, N., Yonekawa, T., Matsushita, T., Masaki, K., Yoshimura, S., Fichna, J., Chen, S., Furmaniak, J., Smith, B. R. & Kira, J. I., May 1 2013, In : Neurochemical Research. 38, 5, p. 997-1001 5 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Distinct genetic and infectious profiles in Japanese neuromyelitis optica patients according to anti-aquaporin 4 antibody status

Yoshimura, S., Isobe, N., Matsushita, T., Yonekawa, T., Masaki, K., Sato, S., Kawano, Y., Kira, J. I., Miyamoto, K., Kusunoki, S., Nakatsuji, Y., Mochizuki, H., Ochi, K., Matsumoto, M., Kanda, T., Ochi, H., Miki, T., Okada, K. & Tsuji, S., Jan 2013, In : Journal of Neurology, Neurosurgery and Psychiatry. 84, 1, p. 29-34 6 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)