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  • 2019
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Author

  • Keiichi Nakayama
Article

A 23 gene–based molecular prognostic score precisely predicts overall survival of breast cancer patients

Shimizu, H. & Nakayama, K. I., Aug 2019, In : EBioMedicine. 46, p. 150-159 10 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Acetaldehyde administrationinduces salsolinol formation in vivo in the dorsal striatum of Aldh2-knockout and C57BL/6N mice

Ito, A., Jamal, M., Ameno, K., Tanaka, N., Takakura, A., Kawamoto, T., Kitagawa, K., Nakayama, K., Matsumoto, A., Miki, T. & Kinoshita, H., Oct 15 2018, In : Neuroscience Letters. 685, p. 50-54 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Akt1-mediated Gata3 phosphorylation controls the repression of IFNÎ 3 in memory-type Th2 cells

Hosokawa, H., Tanaka, T., Endo, Y., Kato, M., Shinoda, K., Suzuki, A., Motohashi, S., Matsumoto, M., Nakayama, K. I. & Nakayama, T., Apr 7 2016, In : Nature communications. 7, 11289.

Research output: Contribution to journalArticle

12 Citations (Scopus)

A large-scale targeted proteomics assay resource based on an in vitro human proteome

Matsumoto, M., Matsuzaki, F., Oshikawa, K., Goshima, N., Mori, M., Kawamura, Y., Ogawa, K., Fukuda, E., Nakatsumi, H., Natsume, T., Fukui, K., Horimoto, K., Nagashima, T., Funayama, R., Nakayama, K. & Nakayama, K. I., Feb 28 2017, In : Nature Methods. 14, 3, p. 251-258 8 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Bcl11b sets pro-T cell fate by site-specific cofactor recruitment and by repressing Id2 and Zbtb16

Hosokawa, H., Romero-Wolf, M., Yui, M. A., Ungerbäck, J., Quiloan, M. L. G., Matsumoto, M., Nakayama, K. I., Tanaka, T. & Rothenberg, E. V., Dec 1 2018, In : Nature Immunology. 19, 12, p. 1427-1440 14 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

CHD8 haploinsufficiency results in autistic-like phenotypes in mice

Katayama, Y., Nishiyama, M., Shoji, H., Ohkawa, Y., Kawamura, A., Sato, T., Suyama, M., Takumi, T., Miyakawa, T. & Nakayama, K. I., Jan 1 2016, In : Nature. 537, 7622, p. 675-679 5 p.

Research output: Contribution to journalArticle

96 Citations (Scopus)

Combined mutation of Apc, Kras, and Tgfbr2 effectively drives metastasis of intestinal cancer

Sakai, E., Nakayama, M., Oshima, H., Kouyama, Y., Niida, A., Fujii, S., Ochiai, A., Nakayama, K. I., Mimori, K., Suzuki, Y., Hong, C. P., Ock, C. Y., Kim, S. J. & Oshima, M., Mar 1 2018, In : Cancer Research. 78, 5, p. 1334-1346 13 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Decreased Brain pH as a Shared Endophenotype of Psychiatric Disorders

Hagihara, H., Catts, V. S., Katayama, Y., Shoji, H., Takagi, T., Huang, F. L., Nakao, A., Mori, Y., Huang, K. P., Ishii, S., Graef, I. A., Nakayama, K. I., Shannon Weickert, C. & Miyakawa, T., Feb 1 2018, In : Neuropsychopharmacology. 43, 3, p. 459-468 10 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Degradation of the endoplasmic reticulum–anchored transcription factor MyRF by the ubiquitin ligase SCFFbxw7 in a manner dependent on the kinase GSK-3

Nakayama, S., Yumimoto, K., Kawamura, A. & Nakayama, K. I., Apr 13 2018, In : Journal of Biological Chemistry. 293, 15, p. 5705-5714 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis

Muto, Y., Moroishi, T., Ichihara, K., Nishiyama, M., Shimizu, H., Eguchi, H., Moriya, K., Koike, K., Mimori, K., Mori, M., Katayama, Y. & Nakayama, K. I., Apr 1 2019, In : Journal of Experimental Medicine. 216, 4, p. 950-965 16 p.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells

Muto, Y., Nishiyama, M., Nita, A., Moroishi, T. & Nakayama, K. I., Jul 17 2017, In : Nature communications. 8, 16114.

Research output: Contribution to journalArticle

16 Citations (Scopus)

F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner

Yumimoto, K., Akiyoshi, S., Ueo, H., Sagara, Y., Onoyama, I., Ueo, H., Ohno, S., Mori, M., Mimori, K. & Nakayama, K. I., Feb 2 2015, In : Journal of Clinical Investigation. 125, 2, p. 621-635 15 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)

FBXL12-mediated degradation of ALDH3 is essential for trophoblast differentiation during placental development

Nishiyama, M., Nita, A., Yumimoto, K. & Nakayama, K. I., Nov 2015, In : STEM CELLS. 33, 11, p. 3327-3340 14 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

FBXL12 regulates T-cell differentiation in a cell-autonomous manner

Nita, A., Nishiyama, M., Muto, Y. & Nakayama, K., May 1 2016, In : Genes to Cells. 21, 5, p. 517-524 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

FBXL5 inactivation in mouse brain induces aberrant proliferation of neural stem progenitor cells

Yamauchi, T., Nishiyama, M., Moroishi, T., Kawamura, A. & Nakayama, K. I., Apr 1 2017, In : Molecular and cellular biology. 37, 8, e00470-16.

Research output: Contribution to journalArticle

8 Citations (Scopus)

FBXO21 mediates the ubiquitylation and proteasomal degradation of EID1

Watanabe, K., Yumimoto, K. & Nakayama, K. I., Aug 1 2015, In : Genes to Cells. 20, 8, p. 667-674 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

FBXW7 is involved in the acquisition of the malignant phenotype in epithelial ovarian tumors

Kitade, S., Onoyama, I., Kobayashi, H., Yagi, H., Yoshida, S., Kato, M., Tsunematsu, R., Asanoma, K., Sonoda, K., Wake, N., Hata, K., Nakayama, K. I. & Kato, K., Oct 1 2016, In : Cancer Science. 107, 10, p. 1399-1405 7 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Fbxw7 suppresses cancer metastasis by inhibiting niche formation

Yumimoto, K. & Nakayama, K. I., Aug 3 2015, In : OncoImmunology. 4, 8

Research output: Contribution to journalArticle

5 Citations (Scopus)

Frequent detection of pituitary-derived PRPREs in human prion diseases

Honda, H., Matsumoto, M., Shijo, M., Hamasaki, H., Sadashima, S., Suzuki, S. O., Aishima, S., Kai, K., Nakayama, K. I., Sasagasako, N. & Iwaki, T., Oct 1 2019, In : Journal of neuropathology and experimental neurology. 78, 10, p. 922-929 8 p.

Research output: Contribution to journalArticle

GRWD1 negatively regulates p53 via the RPL11–MDM2 pathway and promotes tumorigenesis

Kayama, K., Watanabe, S., Takafuji, T., Tsuji, T., Hironaka, K., Matsumoto, M., Nakayama, K. I., Enari, M., Kohno, T., Shiraishi, K., Kiyono, T., Yoshida, K., Sugimoto, N. & Fujita, M., Jan 1 2017, In : EMBO Reports. 18, 1, p. 123-137 15 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

GRWD1 regulates ribosomal protein L23 levels via the ubiquitin-proteasome system

Watanabe, S., Fujiyama, H., Takafuji, T., Kayama, K., Matsumoto, M., Nakayama, K. I., Yoshida, K., Sugimoto, N. & Fujita, M., Aug 1 2018, In : Journal of cell science. 131, 15

Research output: Contribution to journalArticle

5 Citations (Scopus)

Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp2

Zhang, S., Chen, Q., Liu, Q., Li, Y., Sun, X., Hong, L., Ji, S., Liu, C., Geng, J., Zhang, W., Lu, Z., Yin, Z. Y., Zeng, Y., Lin, K. H., Wu, Q., Li, Q., Nakayama, K., Nakayama, K. I., Deng, X., Johnson, R. L. & 4 others, Zhu, L., Gao, D., Chen, L. & Zhou, D., May 8 2017, In : Cancer Cell. 31, 5, p. 669-684.e7

Research output: Contribution to journalArticle

54 Citations (Scopus)

Identification of low-abundance proteins in serum via the isolation of HSP72 complexes

Tanaka, M., Shiota, M., Nakao, T., Uemura, R., Nishi, S., Ohkawa, Y., Matsumoto, M., Yamaguchi, M., Osada-Oka, M., Inagaki, A., Takahashi, K., Nakayama, K. I., Gi, M., Izumi, Y., Miura, K. & Iwao, H., Mar 16 2016, In : Journal of Proteomics. 136, p. 214-221 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Inhibiting Skp2 E3 ligase suppresses bleomycin-induced pulmonary fibrosis

Mikamo, M., Kitagawa, K., Sakai, S., Uchida, C., Ohhata, T., Nishimoto, K., Niida, H., Suzuki, S., Nakayama, K. I., Inui, N., Suda, T. & Kitagawa, M., Feb 6 2018, In : International journal of molecular sciences. 19, 2, 474.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Liver maturation deficiency in p57Kip2-/- mice occurs in a hepatocytic p57Kip2 expression-independent manner

Yanagida, A., Chikada, H., Ito, K., Umino, A., Kato-Itoh, M., Yamazaki, Y., Sato, H., Kobayashi, T., Yamaguchi, T., Nakayama, K. I., Nakauchi, H. & Kamiya, A., Nov 15 2015, In : Developmental Biology. 407, 2, p. 331-343 13 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Maternal TET3 is dispensable for embryonic development but is required for neonatal growth

Tsukada, Y. I., Akiyama, T. & Nakayama, K. I., Oct 28 2015, In : Scientific reports. 5, 15876.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Methylation of Gata3 protein at Arg-261 regulates transactivation of the Il5 gene in T helper 2 cells

Hosokawa, H., Kato, M., Tohyama, H., Tamaki, Y., Endo, Y., Kimura, M. Y., Tumes, D. J., Motohashi, S., Matsumoto, M., Nakayama, K. I., Tanaka, T. & Nakayama, T., May 22 2015, In : Journal of Biological Chemistry. 290, 21, p. 13095-13103 9 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

MTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide

Matsumoto, A., Pasut, A., Matsumoto, M., Yamashita, R., Fung, J., Monteleone, E., Saghatelian, A., Nakayama, K. I., Clohessy, J. G. & Pandolfi, P. P., Jan 12 2017, In : Nature. 541, 7636, p. 228-232 5 p.

Research output: Contribution to journalArticle

184 Citations (Scopus)

mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide.

Matsumoto, A., Pasut, A., Matsumoto, M., Yamashita, R., Fung, J., Monteleone, E., Saghatelian, A., Nakayama, K., Clohessy, J. & Pandolfi, P. P., 2017, In : Nature. 541, 7636, p. 228 5 p., 541.

Research output: Contribution to journalArticle

Noncanonical Pathway for Regulation of CCL2 Expression by an mTORC1-FOXK1 Axis Promotes Recruitment of Tumor-Associated Macrophages

Nakatsumi, H., Matsumoto, M. & Nakayama, K. I., Nov 28 2017, In : Cell Reports. 21, 9, p. 2471-2486 16 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis

Fukushima, H., Shimizu, K., Watahiki, A., Hoshikawa, S., Kosho, T., Oba, D., Sakano, S., Arakaki, M., Yamada, A., Nagashima, K., Okabe, K., Fukumoto, S., Jimi, E., Bigas, A., Nakayama, K. I., Nakayama, K., Aoki, Y., Wei, W. & Inuzuka, H., Nov 16 2017, In : Molecular Cell. 68, 4, p. 645-658.e5

Research output: Contribution to journalArticle

13 Citations (Scopus)

Nuclear–cytoplasmic shuttling protein PP2AB56 contributes to mTORC1-dependent dephosphorylation of FOXK1

Nakatsumi, H., Oka, T., Higa, T., Shirane, M. & Nakayama, K. I., Jul 2018, In : Genes to Cells. 23, 7, p. 599-605 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

p57Kip2 knock-in mouse reveals CDK-independent contribution in the development of Beckwith–Wiedemann syndrome

Duquesnes, N., Callot, C., Jeannot, P., Daburon, V., Nakayama, K. I., Manenti, S., Davy, A. & Besson, A., Jul 1 2016, In : Journal of Pathology. 239, 3, p. 250-261 12 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Peroxisome biogenesis deficiency attenuates the BDNF-TrkB pathway-mediated development of the cerebellum

Abe, Y., Honsho, M., Itoh, R., Kawaguchi, R., Fujitani, M., Fujiwara, K., Hirokane, M., Matsuzaki, T., Nakayama, K., Ohgi, R., Marutani, T., Nakayama, K. I., Yamashita, T. & Fujiki, Y., 2018, In : Life Science Alliance. 1, 6

Research output: Contribution to journalArticle

4 Citations (Scopus)

Phosphoproteomics analyses show subnetwork systems in T-cell receptor signaling

Hatano, A., Matsumoto, M. & Nakayama, K. I., Oct 1 2016, In : Genes to Cells. 21, 10, p. 1095-1112 18 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Pillars Article: Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes. Science. 1993. 259: 822-825

Shinkai, Y., Koyasu, S., Nakayama, K. I., Murphy, K. M., Loh, D. Y., Reinherz, E. L. & Alt, F. W., Mar 1 2019, In : Journal of immunology (Baltimore, Md. : 1950). 202, 5, p. 1317-1320 4 p.

Research output: Contribution to journalArticle

PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth

Morita, M., Sato, T., Nomura, M., Sakamoto, Y., Inoue, Y., Tanaka, R., Ito, S., Kurosawa, K., Yamaguchi, K., Sugiura, Y., Takizaki, H., Yamashita, Y., Katakura, R., Sato, I., Kawai, M., Okada, Y., Watanabe, H., Kondoh, G., Matsumoto, S., Kishimoto, A. & 12 others, Obata, M., Matsumoto, M., Fukuhara, T., Motohashi, H., Suematsu, M., Komatsu, M., Nakayama, K. I., Watanabe, T., Soga, T., Shima, H., Maemondo, M. & Tanuma, N., Mar 12 2018, In : Cancer Cell. 33, 3, p. 355-367.e7

Research output: Contribution to journalArticle

34 Citations (Scopus)

Prevention of cancer dormancy by Fbxw7 ablation eradicates disseminated tumor cells

Shimizu, H., Takeishi, S., Nakatsumi, H. & Nakayama, K. I., 2019, In : JCI Insight. 4, 4, e125138.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Protection of stromal cell-derived factor 2 by heat shock protein 72 prevents oxaliplatin-induced cell death in oxaliplatin-resistant human gastric cancer cells

Takahashi, K., Tanaka, M., Yashiro, M., Matsumoto, M., Ohtsuka, A., Nakayama, K. I., Izumi, Y., Nagayama, K., Miura, K., Iwao, H. & Shiota, M., Aug 1 2016, In : Cancer Letters. 378, 1, p. 8-15 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Reconstruction of global regulatory network from signaling to cellular functions using phosphoproteomic data

Kawata, K., Yugi, K., Hatano, A., Kokaji, T., Tomizawa, Y., Fujii, M., Uda, S., Kubota, H., Matsumoto, M., Nakayama, K. I. & Kuroda, S., Jan 2019, In : Genes to Cells. 24, 1, p. 82-93 12 p.

Research output: Contribution to journalArticle

Regulation of GATA-binding protein 2 levels via ubiquitin-dependent degradation by Fbw7: Involvement of cyclin B-cyclin-dependent kinase 1-mediated phosphorylation of Thr176 in GATA-binding protein 2

Nakajima, T., Kitagawa, K., Ohhata, T., Sakai, S., Uchida, C., Shibata, K., Minegishi, N., Yumimoto, K., Nakayama, K. I., Masumoto, K., Katou, F., Niida, H. & Kitagawa, M., Apr 17 2015, In : Journal of Biological Chemistry. 290, 16, p. 10368-10381 14 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Ribophorin ii is involved in the tissue factor expression mediated by phosphatidylserinedependent antiprothrombin antibody on monocytes

Fujieda, Y., Amengual, O., Matsumoto, M., Kuroki, K., Takahashi, H., Kono, M., Kurita, T., Otomo, K., Kato, M., Oku, K., Bohgaki, T., Horita, T., Yasuda, S., Maenaka, K., Hatakeyama, S., Nakayama, K. I. & Atsumi, T., Jun 1 2016, In : Rheumatology (United Kingdom). 55, 6, p. 1117-1126 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Role of apolipoprotein B100 and oxidized low-density lipoprotein in the monocyte tissue factor induction mediated by anti-β2 glycoprotein i antibodies

Otomo, K., Amengual, O., Fujieda, Y., Nakagawa, H., Kato, M., Oku, K., Horita, T., Yasuda, S., Matsumoto, M., Nakayama, K. I., Hatakeyama, S., Koike, T. & Atsumi, T., Oct 1 2016, In : Lupus. 25, 12, p. 1288-1298 11 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Role of the Atg9a gene in intrauterine growth and survival of fetal mice

Kojima, T., Yamada, T., Akaishi, R., Furuta, I., Saitoh, T., Nakabayashi, K., Nakayama, K. I., Nakayama, K., Akira, S. & Minakami, H., Sep 1 2015, In : Reproductive Biology. 15, 3, p. 131-138 8 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

SCFFbxw7 ubiquitylates KLF7 for degradation in a manner dependent on GSK-3-mediated phosphorylation

Sugiyama, S., Yumimoto, K., Inoue, I. & Nakayama, K. I., May 2019, In : Genes to Cells. 24, 5, p. 354-365 12 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Sez6l2 regulates phosphorylation of ADD and neuritogenesis

Yaguchi, H., Yabe, I., Takahashi, H., Watanabe, M., Nomura, T., Kano, T., Matsumoto, M., Nakayama, K. I., Watanabe, M. & Hatakeyama, S., Dec 9 2017, In : Biochemical and Biophysical Research Communications. 494, 1-2, p. 234-241 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

SKP2 inactivation suppresses prostate tumorigenesis by mediating JARID1B ubiquitination

Lu, W., Liu, S., Li, B., Xie, Y., Adhiambo, C., Yang, Q., Ballard, B. R., Nakayama, K. I., Matusik, R. J. & Chen, Z., 2015, In : Oncotarget. 6, 2, p. 771-788 18 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Slowly dividing neural progenitors are an embryonic origin of adult neural stem cells

Furutachi, S., Miya, H., Watanabe, T., Kawai, H., Yamasaki, N., Harada, Y., Imayoshi, I., Nelson, M., Nakayama, K. I., Hirabayashi, Y. & Gotoh, Y., Apr 28 2015, In : Nature Neuroscience. 18, 5, p. 657-665 9 p.

Research output: Contribution to journalArticle

125 Citations (Scopus)

SRRM4-dependent neuron-specific alternative splicing of protrudin transcripts regulates neurite outgrowth

Ohnishi, T., Shirane, M. & Nakayama, K. I., Jan 20 2017, In : Scientific reports. 7, 41130.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Structural basis for the assembly of the Ragulator-Rag GTPase complex

Yonehara, R., Nada, S., Nakai, T., Nakai, M., Kitamura, A., Ogawa, A., Nakatsumi, H., Nakayama, K. I., Li, S., Standley, D. M., Yamashita, E., Nakagawa, A. & Okada, M., Dec 1 2017, In : Nature communications. 8, 1, 1625.

Research output: Contribution to journalArticle

20 Citations (Scopus)