8-Oxoguanine accumulation in aged female brain impairs neurogenesis in the dentate gyrus and major island of Calleja, causing sexually dimorphic phenotypes
Haruyama, N., Sakumi, K., Katogi, A., Tsuchimoto, D., De Luca, G., Bignami, M. & Nakabeppu, Y., Sep 2019, In : Progress in Neurobiology. 180, 101613.Research output: Contribution to journal › Article
Diabetes Mellitus, A risk factor for Alzheimer's Disease
Nakabeppu, Y. (ed.) & Ninomiya, T. (ed.), May 7 2019, Singapore: Springer. 248 p. (Advances in Experimental Medicine and Biology)Research output: Book/Report › Book
Molecular pathophysiology of insulin depletion, mitochondrial dysfunction, and oxidative stress in Alzheimer’s disease brain
Nakabeppu, Y., Jan 1 2019, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 27-44 18 p. (Advances in Experimental Medicine and Biology; vol. 1128).Research output: Chapter in Book/Report/Conference proceeding › Chapter
Origins of brain insulin and its function
Nakabeppu, Y., Jan 1 2019, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 1-11 11 p. (Advances in Experimental Medicine and Biology; vol. 1128).Research output: Chapter in Book/Report/Conference proceeding › Chapter
Oxidative stress induces different tissue dependent effects on Mutyh-deficient mice
Chen, J., Huang, Z., Wu, X., Kang, J., Ren, Y., Gao, W., Lu, X., Wang, J., Ding, W., Nakabeppu, Y., Fan, Y. & Wang, Y., Nov 1 2019, In : Free Radical Biology and Medicine. 143, p. 482-493 12 p.Research output: Contribution to journal › Article
An intronic single nucleotide polymorphism in the MUTYH gene is associated with increased risk for HCV-induced hepatocellular carcinoma
Sakurada, A., Miyanishi, K., Tanaka, S., Sato, M., Sakamoto, H., Kawano, Y., Takada, K., Nakabeppu, Y., Kobune, M. & Kato, J., Dec 1 2018, In : Free Radical Biology and Medicine. 129, p. 88-96 9 p.Research output: Contribution to journal › Article
A Novel Autoantibody against Plexin D1 in Patients with Neuropathic Pain
Fujii, T., Yamasaki, R., Iinuma, K., Tsuchimoto, D., Hayashi, Y., Saitoh, B. Y., Matsushita, T., Kido, M. A., Aishima, S., Nakanishi, H., Nakabeppu, Y. & Kira, J. I., Aug 2018, In : Annals of Neurology. 84, 2, p. 208-224 17 p.Research output: Contribution to journal › Article
Association of adipocyte enhancer-binding protein 1 with Alzheimer's disease pathology in human hippocampi
Shijo, M., Honda, H., Suzuki, S. O., Hamasaki, H., Hokama, M., Abolhassani, N., Nakabeppu, Y., Ninomiya, T., Kitazono, T. & Iwaki, T., Jan 2018, In : Brain Pathology. 28, 1, p. 58-71 14 p.Research output: Contribution to journal › Article
Expression of CRYM in different rat organs during development and its decreased expression in degenerating pyramidal tracts in amyotrophic lateral sclerosis
Hommyo, R., Suzuki, S. O., Abolhassani, N., Hamasaki, H., Shijo, M., Maeda, N., Honda, H., Nakabeppu, Y. & Iwaki, T., Jun 2018, In : Neuropathology. 38, 3, p. 247-259 13 p.Research output: Contribution to journal › Article
The Disease-modifying Drug Candidate, SAK3 Improves Cognitive Impairment and Inhibits Amyloid beta Deposition in App Knock-in Mice
Izumi, H., Shinoda, Y., Saito, T., Saido, T. C., Sato, K., Yabuki, Y., Matsumoto, Y., Kanemitsu, Y., Tomioka, Y., Abolhassani, N., Nakabeppu, Y. & Fukunaga, K., May 1 2018, In : Neuroscience. 377, p. 87-97 11 p.Research output: Contribution to journal › Article
2-Oxoadenosine induces cytotoxicity through intracellular accumulation of 2-oxo-ATP and depletion of ATP but not via the p38 MAPK pathway
Asada, S., Ohta, E., Akimoto, Y., Abolhassani, N., Tsuchimoto, D. & Nakabeppu, Y., Dec 1 2017, In : Scientific Reports. 7, 1, 6528.Research output: Contribution to journal › Article
8-oxoguanine DNA glycosylase (OGG1) deficiency elicits coordinated changes in lipid and mitochondrial metabolism in muscle
Vartanian, V., Tumova, J., Dobrzyn, P., Dobrzyn, A., Nakabeppu, Y., Lloyd, R. S. & Sampath, H., Jul 2017, In : PloS one. 12, 7, e0181687.Research output: Contribution to journal › Article
Association of MTH1 expression with the tumor malignant potential and poor prognosis in patients with resected lung cancer
Fujishita, T., Okamoto, T., Akamine, T., Takamori, S., Takada, K., Katsura, M., Toyokawa, G., Shoji, F., Shimokawa, M., Oda, Y., Nakabeppu, Y. & Maehara, Y., Jul 1 2017, In : Lung Cancer. 109, p. 52-57 6 p.Research output: Contribution to journal › Article
Celecoxib and 2,5-dimethylcelecoxib inhibit intestinal cancer growth by suppressing the Wnt/β-catenin signaling pathway
Egashira, I., Takahashi-Yanaga, F., Nishida, R., Arioka, M., Igawa, K., Tomooka, K., Nakatsu, Y., Tsuzuki, T., Nakabeppu, Y., Kitazono, T. & Sasaguri, T., Jan 1 2017, In : Cancer Science. 108, 1, p. 108-115 8 p.Research output: Contribution to journal › Article
Chronic atypical antipsychotics, but not haloperidol, increase neurogenesis in the hippocampus of adult mouse
Chikama, K., Yamada, H., Tsukamoto, T., Kajitani, K., Nakabeppu, Y. & Uchimura, N., Dec 1 2017, In : Brain Research. 1676, p. 77-82 6 p.Research output: Contribution to journal › Article
Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation
Castillo, E., Leon, J., Mazzei, G., Abolhassani, N., Haruyama, N., Saito, T., Saido, T., Hokama, M., Iwaki, T., Ohara, T., Ninomiya, T., Kiyohara, Y., Sakumi, K., Laferla, F. M. & Nakabeppu, Y., Dec 1 2017, In : Scientific reports. 7, 1, 17762.Research output: Contribution to journal › Article
Complexity of Stomach–Brain Interaction Induced by Molecular Hydrogen in Parkinson’s Disease Model Mice
Yoshii, Y., Inoue, T., Uemura, Y., Iwasaki, Y., Yada, T., Nakabeppu, Y. & Noda, M., Sep 1 2017, In : Neurochemical Research. 42, 9, p. 2658-2665 8 p.Research output: Contribution to journal › Article
Co-regulation of Cxcl1 and versican in the inflammatory response to UVB induced reactive oxygen species in skin photo-tumorigenesis
Takemori, C., Kunisada, M., Yogianti, F., Oka, S., Kunihiko, S., Ono, R., Nakabeppu, Y. & Nishigori, C., Feb 1 2017, In : Journal of Dermatological Science. 85, 2, p. 140-143 4 p.Research output: Contribution to journal › Letter
Fenton reaction-induced renal carcinogenesis in Mutyh-deficient mice exhibits less chromosomal aberrations than the rat model
Li, G. H., Akatsuka, S., Chew, S. H., Jiang, L., Nishiyama, T., Sakamoto, A., Takahashi, T., Futakuchi, M., Suzuki, H., Kunihiko, S., Nakabeppu, Y. & Toyokuni, S., Nov 1 2017, In : Pathology International. 67, 11, p. 564-574 11 p.Research output: Contribution to journal › Article
Molecular pathophysiology of impaired glucose metabolism, mitochondrial dysfunction, and oxidative DNA damage in Alzheimer's disease brain
Abolhassani, N., Leon, J., Sheng, Z., Oka, S., Hamasaki, H., Iwaki, T. & Nakabeppu, Y., Jan 15 2017, In : Mechanisms of Ageing and Development. 161, Pt A, p. 95-104 15 p.Research output: Contribution to journal › Article
MTH1 as a nucleotide pool sanitizing enzyme: Friend or foe?
Nakabeppu, Y., Ohta, E. & Abolhassani, N., Jun 1 2017, In : Free Radical Biology and Medicine. 107, p. 151-158 8 p.Research output: Contribution to journal › Review article
Neurodegeneration caused by accumulation of an oxidized base lesion, 8-oxoguanine, in nuclear and mitochondrial DNA: from animal models to human diseases.
Nakabeppu, Y., Apr 1 2017, The Base Excision Repair Pathway: Molecular Mechanisms and Role in Disease Development and Therapeutic Design . World Scientific Publishing Co. Pte Ltd, p. 523-556 34 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
Prognostic impact of MutT homolog-1 expression on esophageal squamous cell carcinoma
Akiyama, S., Saeki, H., Nakashima, Y., Iimori, M., Kitao, H., Oki, E., Oda, Y., Nakabeppu, Y., Kakeji, Y. & Maehara, Y., Jan 1 2017, In : Cancer Medicine. 6, 1, p. 258-266 9 p.Research output: Contribution to journal › Article
Role of the DNA repair glycosylase OGG1 in the activation of murine splenocytes
Seifermann, M., Ulges, A., Bopp, T., Melcea, S., Schäfer, A., Oka, S., Nakabeppu, Y., Klungland, A., Niehrs, C. & Epe, B., Oct 1 2017, In : DNA Repair. 58, p. 13-20 8 p.Research output: Contribution to journal › Article
Serum galectin-3, but not galectin-1, levels are elevated in schizophrenia: implications for the role of inflammation
Kajitani, K., Yanagimoto, K. & Nakabeppu, Y., Oct 1 2017, In : Psychopharmacology. 234, 19, p. 2919-2927 9 p.Research output: Contribution to journal › Article
Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity
Waz, S., Nakamura, T., Hirata, K., Ogawa, Y. K., Chirifu, M., Arimori, T., Tamada, T., Ikemizu, S., Nakabeppu, Y. & Yamagata, Y., Feb 17 2017, In : Journal of Biological Chemistry. 292, 7, p. 2785-2794 10 p.Research output: Contribution to journal › Article
8-Oxoguanine accumulation in mitochondrial DNA causes mitochondrial dysfunction and impairs neuritogenesis in cultured adult mouse cortical neurons under oxidative conditions
Leon, J., Sakumi, K., Castillo, E., Sheng, Z., Oka, S. & Nakabeppu, Y., Feb 25 2016, In : Scientific reports. 6, 22086.Research output: Contribution to journal › Article
Corrigendum: 8-Oxoguanine accumulation in mitochondrial DNA causes mitochondrial dysfunction and impairs neuritogenesis in cultured adult mouse cortical neurons under oxidative conditions
Leon, J., Kunihiko, S., Castillo, E., Sheng, Z., Oka, S. & Nakabeppu, Y., Feb 25 2016, In : Scientific reports. 6, 24696.Research output: Contribution to journal › Comment/debate
Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity
Massaad, M. J., Zhou, J., Tsuchimoto, D., Chou, J., Jabara, H., Janssen, E., Glauzy, S., Olson, B. G., Morbach, H., Ohsumi, T. K., Schmitz, K., Kyriacos, M., Kane, J., Torisu, K., Nakabeppu, Y., Notarangelo, L. D., Chouery, E., Megarbane, A., Kang, P. B., Al-Idrissi, E. & 8 others, , Nov 1 2016, In : Journal of Clinical Investigation. 126, 11, p. 4219-4236 18 p.Research output: Contribution to journal › Article
Deoxyinosine triphosphate induces MLH1/PMS2- and p53-dependent cell growth arrest and DNA instability in mammalian cells
Yoneshima, Y., Abolhassani, N., Iyama, T., Sakumi, K., Shiomi, N., Mori, M., Shiomi, T., Noda, T., Tsuchimoto, D. & Nakabeppu, Y., Sep 13 2016, In : Scientific reports. 6, 32849.Research output: Contribution to journal › Article
Erratum: Hyperactive mTOR signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice (Scientific Reports (2016) 6 (22991) DOI: 10.1038/srep22991)
Matsushita, Y., Sakai, Y., Shimmura, M., Shigeto, H., Nishio, M., Akamine, S., Sanefuji, M., Ishizaki, Y., Torisu, H., Nakabeppu, Y., Suzuki, A., Takada, H. & Hara, T., Jun 10 2016, In : Scientific reports. 6, 27164.Research output: Contribution to journal › Comment/debate
Galectin-1 and galectin-3 as key molecules for peripheral nerve degeneration and regeneration
Takaku, S., Niimi, N., Kadoya, T., Yako, H., Tsukamoto, M., Sakumi, K., Nakabeppu, Y., Horie, H. & Sango, K., Jun 5 2016, In : AIMS Molecular Science. 3, 3, p. 325-337 13 p.Research output: Contribution to journal › Review article
Human mitochondrial transcriptional factor A breaks the mitochondria-mediated vicious cycle in Alzheimer's disease
Oka, S., Leon, J., Sakumi, K., Ide, T., Kang, D., LaFerla, F. M. & Nakabeppu, Y., Nov 29 2016, In : Scientific reports. 6, 37889.Research output: Contribution to journal › Article
Hyperactive mTOR signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice
Matsushita, Y., Sakai, Y., Shimmura, M., Shigeto, H., Nishio, M., Akamine, S., Sanefuji, M., Ishizaki, Y., Torisu, H., Nakabeppu, Y., Suzuki, A., Takada, H. & Hara, T., Mar 10 2016, In : Scientific reports. 6, 22991.Research output: Contribution to journal › Article
MUTYH promotes oxidative microglial activation and inherited retinal degeneration
Nakatake, S., Murakami, Y., Ikeda, Y., Morioka, N., Tachibana, T., Fujiwara, K., Yoshida, N., Notomi, S., Hisatomi, T., Yoshida, S., Ishibashi, T., Nakabeppu, Y. & Sonoda, K. H., Jan 1 2016, In : JCI Insight. 1, 15, e87781.Research output: Contribution to journal › Article
MUTYH promotes oxidative microglial activation and inherited retinal degeneration.
Nakatake, S., Murakami, Y., Ikeda, Y., Morioka, N., Tachibana, T., Fujiwara, K., Yoshida, N., Notomi, S., Hisatomi, T., Yoshida, S., Ishibashi, T., Nakabeppu, Y. & Sonoda, K. H., Sep 22 2016, In : JCI insight. 1, 15, 15 p., e87781.Research output: Contribution to journal › Article
Nucleotide excision repair of oxidised genomic DNA is not a source of urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine
Evans, M. D., Mistry, V., Singh, R., Gackowski, D., Różalski, R., Siomek-Gorecka, A., Phillips, D. H., Zuo, J., Mullenders, L., Pines, A., Nakabeppu, Y., Sakumi, K., Sekiguchi, M., Tsuzuki, T., Bignami, M., Oliński, R. & Cooke, M. S., Oct 1 2016, In : Free Radical Biology and Medicine. 99, p. 385-391 7 p.Research output: Contribution to journal › Article
PKCη deficiency improves lipid metabolism and atherosclerosis in apolipoprotein E-deficient mice
Torisu, K., Zhang, X., Nonaka, M., Kaji, T., Tsuchimoto, D., Kajitani, K., Sakumi, K., Torisu, T., Chida, K., Sueishi, K., Kubo, M., Hata, J., Kitazono, T., Kiyohara, Y. & Nakabeppu, Y., Oct 1 2016, In : Genes to Cells. 21, 10, p. 1030-1048 19 p.Research output: Contribution to journal › Article
Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo
Kubokura, N., Takahashi-Yanaga, F., Arioka, M., Yoshihara, T., Igawa, K., Tomooka, K., Morimoto, S., Nakatsu, Y., Tsuzuki, T., Nakabeppu, Y., Matsumoto, T., Kitazono, T. & Sasaguri, T., Jan 1 2015, In : Journal of Pharmacological Sciences. 127, 4, p. 446-455 10 p.Research output: Contribution to journal › Article
Erratum: Characterization of the structure and expression of mouse Itpa gene and its related sequences in the mouse genome (DNA Research (2015) 12:1 (39-51) DOI: 10.1093/dnares/12.1.39)
Behmanesh, M., Kunihiko, S., Tsuchimoto, D., torisu, K., Ohnishi-Honda, Y., Rancourt, D. E. & Nakabeppu, Y., Apr 1 2015, In : DNA Research. 22, 2, 1 p.Research output: Contribution to journal › Comment/debate
Erratum: Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria (Nucleic Acids Res. (2000) 28 (1355-64))
Ohtsubo, T., Nishioka, K., Imaiso, Y., Iwai, S., Shimokawa, H., Oda, H., Fujiwara, T. & Nakabeppu, Y., Mar 23 2015, In : Nucleic acids research. 43, 7, p. 3870-3871 2 p.Research output: Contribution to journal › Comment/debate
Erratum: MUTYH, an adenine DNA glycosylase, mediates p53 tumor suppression via PARP-dependent cell death (Oncogenesis (2015) 4 (e121) DOI:doi:10.1038/oncsis.2014.35)
Oka, S., Leon, J., Tsuchimoto, D., Sakumi, K. & Nakabeppu, Y., Jan 1 2015, In : Oncogenesis. 4, 2, e142.Research output: Contribution to journal › Comment/debate
Galectin-1 deficiency improves axonal swelling of motor neurones in SOD1G93A transgenic mice
Kobayakawa, Y., Sakumi, K., Kajitani, K., Kadoya, T., Horie, H., Kira, J. I. & Nakabeppu, Y., Feb 1 2015, In : Neuropathology and Applied Neurobiology. 41, 2, p. 227-244 18 p.Research output: Contribution to journal › Article
Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice
Bjørge, M. D., Hildrestrand, G. A., Scheffler, K., Suganthan, R., Rolseth, V., Kuśnierczyk, A., Rowe, A. D., Vågbø, C. B., Vetlesen, S., Eide, L., Slupphaug, G., Nakabeppu, Y., Bredy, T. W., Klungland, A. & Bjørås, M., Dec 29 2015, In : Cell Reports. 13, 12, p. 2671-2678 8 p.Research output: Contribution to journal › Article