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2019
1 Citation (Scopus)

Evidence for detection of rat P2X4 receptor expressed on cells by generating monoclonal antibodies recognizing the native structure

Igawa, T., Kishikawa, S., Abe, Y., Yamashita, T., Nagai, S., Shiroishi, M., Shinozaki, C., Tanaka, H., Saitoh, H., Makoto, T., Inoue, K. & Ueda, T., Jan 1 2019, (Accepted/In press) In : Purinergic Signalling.

Research output: Contribution to journalArticle

Purinergic P2X4 Receptors
Monoclonal Antibodies
Antibodies
Purinergic P2X Receptors
Head

Evidence for detection of rat P2X4 receptor expressed on cells by generating monoclonal antibodies recognizing the native structure

Igawa, T., Kishikawa, S., Abe, Y., Yamashita, T., Nagai, S., Shiroishi, M., Shinozaki, C., Tanaka, H., Tozaki-Saitoh, H., Tsuda, M., Inoue, K. & Ueda, T., Jan 25 2019, In : Purinergic Signalling.

Research output: Contribution to journalArticle

Purinergic P2X4 Receptors
Monoclonal Antibodies
Antibodies
Purinergic P2X Receptors
Head

Hyperactivation of proprioceptors induces microglia-mediated long-lasting pain in a rat model of chronic fatigue syndrome

Yasui, M., Menjyo, Y., Tokizane, K., Shiozawa, A., Tsuda, M., Inoue, K. & Kiyama, H., Mar 30 2019, In : Journal of neuroinflammation. 16, 1, 67.

Research output: Contribution to journalArticle

Open Access
Chronic Fatigue Syndrome
Microglia
Pain
Neurons
Spinal Cord

Macrophage centripetal migration drives spontaneous healing process after spinal cord injury

Kobayakawa, K., Ohkawa, Y., Yoshizaki, S., Tamaru, T., Saito, T., Kijima, K., Yokota, K., Hara, M., Kubota, K., Matsumoto, Y., Harimaya, K., Ozato, K., Masuda, T., Makoto, T., Tamura, T., Inoue, K., Reggie Edgerton, V., Iwamoto, Y., Nakashima, Y. & Okada, S., May 15 2019, In : Science Advances. 5, 5, eaav5086.

Research output: Contribution to journalArticle

Open Access
spinal cord injuries
macrophages
healing
interferon
lesions

Role of P2X3 receptors in scratching behavior in mouse models

Shiratori, M., Hasegawa, A., Toyonaga, H., Andoh, T., Nakahara, T., Nakahara, M., Furue, M., Kuraishi, Y., Inoue, K., Dong, X. & Makoto, T., Mar 1 2019, In : Journal of Allergy and Clinical Immunology. 143, 3, p. 1252-1254.e8

Research output: Contribution to journalArticle

Purinergic P2X3 Receptors
2 Citations (Scopus)

Role of the P2X4 receptor in neuropathic pain

Inoue, K., Aug 1 2019, In : Current Opinion in Pharmacology. 47, p. 33-39 7 p.

Research output: Contribution to journalReview article

Purinergic P2X4 Receptors
Neuralgia
Purinergic P2 Receptors
Pain
Peripheral Nerve Injuries
2 Citations (Scopus)

Transcription factor MafB contributes to the activation of spinal microglia underlying neuropathic pain development

Saitoh, H., Masuda, J., Kawada, R., Kojima, C., Yoneda, S., Masuda, T., Inoue, K. & Makoto, T., Apr 1 2019, In : GLIA. 67, 4, p. 729-740 12 p.

Research output: Contribution to journalArticle

MafB Transcription Factor
Peripheral Nerve Injuries
Microglia
Neuralgia
Hypersensitivity
2018
2 Citations (Scopus)

A state-of-the-art perspective on microgliopathic pain

Inoue, K., Nov 1 2018, In : Open Biology. 8, 11, 180154.

Research output: Contribution to journalReview article

Microglia
Neuralgia
Pain
Peripheral Nerve Injuries
Chronic Pain
3 Citations (Scopus)

Astrocytic Ca2+ responses in the spinal dorsal horn by noxious stimuli to the skin

Yoshihara, K., Matsuda, T., Koro, Y., Saitoh, H., Inoue, K. & Makoto, T., May 1 2018, In : Journal of Pharmacological Sciences. 137, 1, p. 101-104 4 p.

Research output: Contribution to journalArticle

Astrocytes
Skin
Automatic Data Processing
Photons
Formaldehyde

Green Pharma: A new strategy for drug discovery in academia by targeting glial cells and ATP receptors

Yamashita, T., Makoto, T., Saitoh, H. & Inoue, K., Jan 1 2018, In : Yakugaku Zasshi. 138, 8, p. 1027-1031 5 p.

Research output: Contribution to journalReview article

Purinergic P2 Receptors
Drug Discovery
Neuroglia
Hyperalgesia
Neuralgia
47 Citations (Scopus)

Microglia in neuropathic pain: Cellular and molecular mechanisms and therapeutic potential

Inoue, K. & Makoto, T., Feb 16 2018, In : Nature Reviews Neuroscience. 19, 3, p. 138-152 15 p.

Research output: Contribution to journalReview article

Microglia
Neuralgia
Chronic Pain
Nociceptive Pain
Peripheral Nerve Injuries
8 Citations (Scopus)

Optogenetic activation of non-nociceptive aβ fibers induces neuropathic pain-like sensory and emotional behaviors after nerve injury in rats

Tashima, R., Koga, K., Sekine, M., Kanehisa, K., Kohro, Y., Tominaga, K., Matsushita, K., Tozaki-Saitoh, H., Fukazawa, Y., Inoue, K., Yawo, H., Furue, H. & Tsuda, M., Jan 1 2018, In : eNeuro. 5, 1, e0450-17.2018.

Research output: Contribution to journalArticle

Optogenetics
Peripheral Nerve Injuries
Neuralgia
Myelinated Nerve Fibers
Wounds and Injuries
5 Citations (Scopus)

Temporal kinetics of microgliosis in the spinal dorsal horn after peripheral nerve injury in rodents

Kohno, K., Kitano, J., Koro, Y., Saitoh, H., Inoue, K. & Makoto, T., Jan 1 2018, In : Biological and Pharmaceutical Bulletin. 41, 7, p. 1096-1102 7 p.

Research output: Contribution to journalArticle

Peripheral Nerve Injuries
Rodentia
Microglia
Neuralgia
S Phase
19 Citations (Scopus)

Top-down descending facilitation of spinal sensory excitatory transmission from the anterior cingulate cortex

Chen, T., Taniguchi, W., Chen, Q. Y., Tozaki-Saitoh, H., Song, Q., Liu, R. H., Koga, K., Matsuda, T., Kaito-Sugimura, Y., Wang, J., Li, Z. H., Lu, Y. C., Inoue, K., Tsuda, M., Li, Y. Q., Nakatsuka, T. & Zhuo, M., Dec 1 2018, In : Nature communications. 9, 1, 1886.

Research output: Contribution to journalArticle

cortexes
Gyrus Cinguli
pain
Modulation
Synaptic Transmission
2017
27 Citations (Scopus)

Cardiac myofibroblast engulfment of dead cells facilitates recovery after myocardial infarction

Michio, N., Watari, K., Tajima, M., Nakaya, T., Matsuda, S., Ohara, H., Nishihara, H., Yamaguchi, H., Hashimoto, A., Nishida, M., Nagasaka, A., Horii, Y., Ono, H., Iribe, G., Inoue, R., Makoto, T., Inoue, K., Tanaka, A., Kuroda, M., Nagata, S. & 1 others, Kurose, H., Jan 3 2017, In : Journal of Clinical Investigation. 127, 1, p. 383-401 19 p.

Research output: Contribution to journalArticle

Myofibroblasts
Myocardial Infarction
Epidermal Growth Factor
Serum Response Factor
Extracellular Matrix Proteins
1 Citation (Scopus)
Interneurons
Morphine
N-Methyl-D-Aspartate Receptors
Designer Drugs
Substantia Gelatinosa
7 Citations (Scopus)

Fibromyalgia and microglial TNF-α: Translational research using human blood induced microglia-like cells

Ohgidani, M., Kato, T., Hosoi, M., Makoto, T., Hayakawa, K., Hayaki, C., Iwaki, R., Sagata, N., Hashimoto, R., Inoue, K., Sudo, N. & Kanba, S., Dec 1 2017, In : Scientific reports. 7, 1, 11882.

Research output: Contribution to journalArticle

Translational Medical Research
Fibromyalgia
Microglia
Tumor Necrosis Factor-alpha
Adenosine Triphosphate
7 Citations (Scopus)

Neuropharmacological study of atp receptors, especially in the relationship between glia and pain

Inoue, K., Jan 1 2017, In : Yakugaku Zasshi. 137, 5, p. 563-569 7 p.

Research output: Contribution to journalReview article

Microglia
Neuroglia
Pain
Purinergic P2X4 Receptors
Neuralgia
4 Citations (Scopus)
NFATC Transcription Factors
Cell signaling
CC Chemokines
Microglia
Adenosine Diphosphate
12 Citations (Scopus)
pathogenesis
Purinergic P2X4 Receptors
pain
neuroglia
Microglia
2016
31 Citations (Scopus)

A novel P2X4 receptor-selective antagonist produces anti-allodynic effect in a mouse model of herpetic pain

Matsumura, Y., Yamashita, T., Sasaki, A., Nakata, E., Kohno, K., Masuda, T., Tozaki-Saitoh, H., Imai, T., Kuraishi, Y., Tsuda, M. & Inoue, K., Aug 31 2016, In : Scientific reports. 6, 32461.

Research output: Contribution to journalArticle

Purinergic P2X4 Receptors
Chronic Pain
Acute Pain
Pain
Down-Regulation
24 Citations (Scopus)

BK channels in microglia are required for morphine-induced hyperalgesia

Hayashi, Y., Morinaga, S., Zhang, J., Satoh, Y., Meredith, A. L., Nakata, T., Take, H., Kohsaka, S., Inoue, K. & Nakanishi, H., May 31 2016, In : Nature communications. 7, 11697.

Research output: Contribution to journalArticle

morphine
Large-Conductance Calcium-Activated Potassium Channels
Hyperalgesia
Microglia
Morphine
16 Citations (Scopus)

Bone marrow-derived cells in the population of spinal microglia after peripheral nerve injury

Tashima, R., Mikuriya, S., Tomiyama, D., Shiratori, M., Yamashita, T., Koro, Y., Saitoh, H., Inoue, K. & Makoto, T., Mar 23 2016, In : Scientific reports. 6, 23701.

Research output: Contribution to journalArticle

Peripheral Nerve Injuries
Microglia
Bone Marrow Cells
Population
Spinal Cord
48 Citations (Scopus)

Dorsal horn neurons release extracellular ATP in a VNUT-dependent manner that underlies neuropathic pain

Masuda, T., Ozono, Y., Mikuriya, S., Kohro, Y., Tozaki-Saitoh, H., Iwatsuki, K., Uneyama, H., Ichikawa, R., Salter, M. W., Tsuda, M. & Inoue, K., Aug 12 2016, In : Nature communications. 7, 12529.

Research output: Contribution to journalArticle

Posterior Horn Cells
transporter
pain
adenosine triphosphate
nucleotides
18 Citations (Scopus)

Duloxetine inhibits microglial P2X4 receptor function and alleviates neuropathic pain after peripheral nerve injury

Yamashita, T., Yamamoto, S., Zhang, J., Kometani, M., Tomiyama, D., Kohno, K., Tozaki-Saitoh, H., Inoue, K. & Tsuda, M., Oct 2016, In : PloS one. 11, 10, e0165189.

Research output: Contribution to journalArticle

Purinergic P2X4 Receptors
Peripheral Nerve Injuries
peripheral nerves
Neuralgia
pain
31 Citations (Scopus)

Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia

Koyanagi, S., Kusunose, N., Taniguchi, M., Akamine, T., Kanado, Y., Ozono, Y., Masuda, T., Kohro, Y., Matsunaga, N., Tsuda, M., Salter, M. W., Inoue, K. & Ohdo, S., Oct 14 2016, In : Nature communications. 7, 13102.

Research output: Contribution to journalArticle

glucocorticoids
pain
adenosine triphosphate
Hyperalgesia
Astrocytes
4 Citations (Scopus)

Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease

Naoya, M., Ikeda, E., Kakimoto, K., Watanabe, M., Shindo, N., Tsuruta, A., Ikeyama, H., Hamamura, K., Higashi, K., Yamashita, T., Kondo, H., Yoshida, Y., Matsuda, M., Ogino, T., Tokushige, K., Itcho, K., Furuichi, Y., Nakao, T., Yasuda, K., Doi, A. & 7 others, Amamoto, T., Aramaki, H., Makoto, T., Inoue, K., Ojida, A., Satoru, K. & Ohdo, S., Nov 1 2016, In : EBioMedicine. 13, p. 262-273 12 p.

Research output: Contribution to journalArticle

Chronic Renal Insufficiency
Switches
Inflammation
Kidney
Gene encoding
40 Citations (Scopus)

Neuron-microglia interaction by purinergic signaling in neuropathic pain following neurodegeneration

Tsuda, M. & Inoue, K., May 1 2016, In : Neuropharmacology. 104, p. 76-81 6 p.

Research output: Contribution to journalReview article

Microglia
Neuralgia
Neurons
Purinergic P2Y Receptors
Purinergic P2X Receptors
29 Citations (Scopus)

Purinergic P2Y6 receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II-induced hypertension

Nishimura, A., Sunggip, C., Tozaki-Saitoh, H., Shimauchi, T., Numaga-Tomita, T., Hirano, K., Ide, T., Boeynaems, J. M., Kurose, H., Tsuda, M., Robaye, B., Inoue, K. & Nishida, M., Jan 19 2016, In : Science Signaling. 9, 411, aac9187.

Research output: Contribution to journalArticle

Purinergic Receptors
Angiotensin Type 1 Receptor
Angiotensin II
Hypertension
Arrestin

Role of IRF transcription factor family in regulating reactive phenotype of microglia

Masuda, T., Makoto, T. & Inoue, K., Jan 1 2016, In : Seikagaku. 88, 1, p. 124-127 4 p.

Research output: Contribution to journalArticle

Interferon Regulatory Factors
Animals
Transcription Factors
Microglia

The frontline of drug creation for neuropathic pain

Inoue, K., 2016, In : Japanese Journal of Anesthesiology. 65, p. S136-S142

Research output: Contribution to journalArticle

Neuralgia
Pharmaceutical Preparations
3 Citations (Scopus)

Transcriptional regulation in microglia and neuropathic pain

Masuda, T., Makoto, T. & Inoue, K., Apr 1 2016, In : Pain management. 6, 2, p. 91-94 4 p.

Research output: Contribution to journalEditorial

Open Access
Interferon Regulatory Factors
Purinergic P2 Receptors
Gene Expression Regulation
Microglia
Neuralgia
2015
25 Citations (Scopus)

A new minimally-invasive method for microinjection into the mouse spinal dorsal horn

Kohro, Y., Sakaguchi, E., Tashima, R., Tozaki-Saitoh, H., Okano, H., Inoue, K. & Tsuda, M., Sep 21 2015, In : Scientific reports. 5, 14306.

Research output: Contribution to journalArticle

Microinjections
Laminectomy
Inflammation
Gene Expression
Peripheral Nerve Injuries
1 Citation (Scopus)

Effect of adenosine system in the action of oseltamivir on behavior in mice

Uchiyama, H., Hiromura, M., Shiratani, T., Kuroki, H., Honda, S., Kosako, K., Soeda, S., Inoue, K. & Toda, A., Jul 1 2015, In : Neuroscience Letters. 599, p. 7-11 5 p.

Research output: Contribution to journalArticle

Oseltamivir
Adenosine
Walking
Caffeine
Adenosine A2 Receptor Antagonists
2 Citations (Scopus)
Heat transfer
Air quality
Health risks
Numerical analysis
Moisture
8 Citations (Scopus)

Solution structure of the rat P2X4 receptor head domain involved in inhibitory metal binding

Igawa, T., Abe, Y., Makoto, T., Inoue, K. & Ueda, T., Mar 12 2015, In : FEBS Letters. 589, 6, p. 680-686 7 p.

Research output: Contribution to journalArticle

Purinergic P2X4 Receptors
Rats
Metals
Head
Cations
59 Citations (Scopus)

STAT3-dependent reactive astrogliosis in the spinal dorsal horn underlies chronic itch

Shiratori, M., Koga, K., Saitoh, H., Koro, Y., Toyonaga, H., Yamaguchi, C., Hasegawa, A., Nakahara, T., Hachisuka, J., Akira, S., Okano, H., Furue, M., Inoue, K. & Makoto, T., Aug 8 2015, In : Nature medicine. 21, 8, p. 927-931 5 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Lipocalins
Atopic Dermatitis
Dermatitis
Gastrin-Releasing Peptide
21 Citations (Scopus)

Transcription factor IRF1 is responsible for IRF8-mediated IL-1β expression in reactive microglia

Masuda, T., Iwamoto, S., Mikuriya, S., Saitoh, H., Tamura, T., Makoto, T. & Inoue, K., Sep 4 2015, In : Journal of Pharmacological Sciences. 128, 4, p. 216-220 5 p.

Research output: Contribution to journalArticle

Microglia
Interleukin-1
Transcription Factors
Gene Expression
Up-Regulation