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  • Keiichi Nakayama

A 23 gene–based molecular prognostic score precisely predicts overall survival of breast cancer patients

Shimizu, H. & Nakayama, K. I., Aug 2019, In : EBioMedicine. 46, p. 150-159 10 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Acetaldehyde administrationinduces salsolinol formation in vivo in the dorsal striatum of Aldh2-knockout and C57BL/6N mice

Ito, A., Jamal, M., Ameno, K., Tanaka, N., Takakura, A., Kawamoto, T., Kitagawa, K., Nakayama, K., Matsumoto, A., Miki, T. & Kinoshita, H., Oct 15 2018, In : Neuroscience Letters. 685, p. 50-54 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

A large-scale targeted proteomics assay resource based on an in vitro human proteome

Matsumoto, M., Matsuzaki, F., Oshikawa, K., Goshima, N., Mori, M., Kawamura, Y., Ogawa, K., Fukuda, E., Nakatsumi, H., Natsume, T., Fukui, K., Horimoto, K., Nagashima, T., Funayama, R., Nakayama, K. & Nakayama, K. I., Feb 28 2017, In : Nature Methods. 14, 3, p. 251-258 8 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Bcl11b sets pro-T cell fate by site-specific cofactor recruitment and by repressing Id2 and Zbtb16

Hosokawa, H., Romero-Wolf, M., Yui, M. A., Ungerbäck, J., Quiloan, M. L. G., Matsumoto, M., Nakayama, K. I., Tanaka, T. & Rothenberg, E. V., Dec 1 2018, In : Nature Immunology. 19, 12, p. 1427-1440 14 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Brain-derived neurotrophic factor improves limited exercise capacity in mice with heart failure

Matsumoto, J., Takada, S., Kinugawa, S., Furihata, T., Nambu, H., Kakutani, N., Tsuda, M., Fukushima, A., Yokota, T., Tanaka, S., Takahashi, H., Watanabe, M., Hatakeyama, S., Matsumoto, M., Nakayama, K. I., Otsuka, Y., Sabe, H., Tsutsui, H. & Anzai, T., Jan 1 2018, In : Circulation. 138, 18, p. 2064-2066 3 p.

Research output: Contribution to journalLetter

6 Citations (Scopus)

Combined mutation of Apc, Kras, and Tgfbr2 effectively drives metastasis of intestinal cancer

Sakai, E., Nakayama, M., Oshima, H., Kouyama, Y., Niida, A., Fujii, S., Ochiai, A., Nakayama, K. I., Mimori, K., Suzuki, Y., Hong, C. P., Ock, C. Y., Kim, S. J. & Oshima, M., Mar 1 2018, In : Cancer Research. 78, 5, p. 1334-1346 13 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Correction: "UV damage-induced phosphorylation of HBO1 triggers CRL4DDB2-mediated degradation to regulate cell proliferation" [Molecular and Cellular Biology 36, 3, (2016) (394-406)] doi 10.1128/MCB.00809-15

Matsunuma, R., Niida, H., Ohhata, T., Kitagawa, K., Sakai, S., Uchida, C., Shiotani, B., Matsumoto, M., Nakayama, K. I., Ogura, H., Shiiya, N. & Kitagawa, M., Apr 1 2018, In : Molecular and cellular biology. 38, 7, e00572-17.

Research output: Contribution to journalComment/debate

Decreased Brain pH as a Shared Endophenotype of Psychiatric Disorders

Hagihara, H., Catts, V. S., Katayama, Y., Shoji, H., Takagi, T., Huang, F. L., Nakao, A., Mori, Y., Huang, K. P., Ishii, S., Graef, I. A., Nakayama, K. I., Shannon Weickert, C. & Miyakawa, T., Feb 1 2018, In : Neuropsychopharmacology. 43, 3, p. 459-468 10 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Degradation of the endoplasmic reticulum–anchored transcription factor MyRF by the ubiquitin ligase SCFFbxw7 in a manner dependent on the kinase GSK-3

Nakayama, S., Yumimoto, K., Kawamura, A. & Nakayama, K. I., Apr 13 2018, In : Journal of Biological Chemistry. 293, 15, p. 5705-5714 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis

Muto, Y., Moroishi, T., Ichihara, K., Nishiyama, M., Shimizu, H., Eguchi, H., Moriya, K., Koike, K., Mimori, K., Mori, M., Katayama, Y. & Nakayama, K. I., Apr 1 2019, In : Journal of Experimental Medicine. 216, 4, p. 950-965 16 p.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

Erratum: Transcription Factor PU.1 Represses and Activates Gene Expression in Early T Cells by Redirecting Partner Transcription Factor Binding (Immunity (2018) 48(6) (1119–1134.e7), (S1074761318301936) (10.1016/j.immuni.2018.04.024))

Hosokawa, H., Ungerbäck, J., Wang, X., Matsumoto, M., Nakayama, K. I., Cohen, S. M., Tanaka, T. & Rothenberg, E. V., Oct 16 2018, In : Immunity. 49, 4, p. 782 1 p.

Research output: Contribution to journalComment/debate

2 Citations (Scopus)

Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells

Muto, Y., Nishiyama, M., Nita, A., Moroishi, T. & Nakayama, K. I., Jul 17 2017, In : Nature communications. 8, 16114.

Research output: Contribution to journalArticle

16 Citations (Scopus)

F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner

Yumimoto, K., Akiyoshi, S., Ueo, H., Sagara, Y., Onoyama, I., Ueo, H., Ohno, S., Mori, M., Mimori, K. & Nakayama, K. I., Feb 2 2015, In : Journal of Clinical Investigation. 125, 2, p. 621-635 15 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)

FBXL12-mediated degradation of ALDH3 is essential for trophoblast differentiation during placental development

Nishiyama, M., Nita, A., Yumimoto, K. & Nakayama, K. I., Nov 2015, In : STEM CELLS. 33, 11, p. 3327-3340 14 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

FBXL5 inactivation in mouse brain induces aberrant proliferation of neural stem progenitor cells

Yamauchi, T., Nishiyama, M., Moroishi, T., Kawamura, A. & Nakayama, K. I., Apr 1 2017, In : Molecular and cellular biology. 37, 8, e00470-16.

Research output: Contribution to journalArticle

8 Citations (Scopus)

FBXO21 mediates the ubiquitylation and proteasomal degradation of EID1

Watanabe, K., Yumimoto, K. & Nakayama, K. I., Aug 1 2015, In : Genes to Cells. 20, 8, p. 667-674 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Fbxw7 suppresses cancer metastasis by inhibiting niche formation

Yumimoto, K. & Nakayama, K. I., Aug 3 2015, In : OncoImmunology. 4, 8

Research output: Contribution to journalArticle

5 Citations (Scopus)

Frequent detection of pituitary-derived PRPREs in human prion diseases

Honda, H., Matsumoto, M., Shijo, M., Hamasaki, H., Sadashima, S., Suzuki, S. O., Aishima, S., Kai, K., Nakayama, K. I., Sasagasako, N. & Iwaki, T., Oct 1 2019, In : Journal of neuropathology and experimental neurology. 78, 10, p. 922-929 8 p.

Research output: Contribution to journalArticle

GRWD1 negatively regulates p53 via the RPL11–MDM2 pathway and promotes tumorigenesis

Kayama, K., Watanabe, S., Takafuji, T., Tsuji, T., Hironaka, K., Matsumoto, M., Nakayama, K. I., Enari, M., Kohno, T., Shiraishi, K., Kiyono, T., Yoshida, K., Sugimoto, N. & Fujita, M., Jan 1 2017, In : EMBO Reports. 18, 1, p. 123-137 15 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

GRWD1 regulates ribosomal protein L23 levels via the ubiquitin-proteasome system

Watanabe, S., Fujiyama, H., Takafuji, T., Kayama, K., Matsumoto, M., Nakayama, K. I., Yoshida, K., Sugimoto, N. & Fujita, M., Aug 1 2018, In : Journal of cell science. 131, 15

Research output: Contribution to journalArticle

5 Citations (Scopus)

Hidden peptides encoded by putative noncoding RNAs

Matsumoto, A. & Nakayama, K. I., Jan 1 2018, In : Cell structure and function. 43, 1, p. 75-83 9 p.

Research output: Contribution to journalShort survey

16 Citations (Scopus)

Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp2

Zhang, S., Chen, Q., Liu, Q., Li, Y., Sun, X., Hong, L., Ji, S., Liu, C., Geng, J., Zhang, W., Lu, Z., Yin, Z. Y., Zeng, Y., Lin, K. H., Wu, Q., Li, Q., Nakayama, K., Nakayama, K. I., Deng, X., Johnson, R. L. & 4 others, Zhu, L., Gao, D., Chen, L. & Zhou, D., May 8 2017, In : Cancer Cell. 31, 5, p. 669-684.e7

Research output: Contribution to journalArticle

55 Citations (Scopus)

Inhibiting Skp2 E3 ligase suppresses bleomycin-induced pulmonary fibrosis

Mikamo, M., Kitagawa, K., Sakai, S., Uchida, C., Ohhata, T., Nishimoto, K., Niida, H., Suzuki, S., Nakayama, K. I., Inui, N., Suda, T. & Kitagawa, M., Feb 6 2018, In : International journal of molecular sciences. 19, 2, 474.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Liver maturation deficiency in p57Kip2-/- mice occurs in a hepatocytic p57Kip2 expression-independent manner

Yanagida, A., Chikada, H., Ito, K., Umino, A., Kato-Itoh, M., Yamazaki, Y., Sato, H., Kobayashi, T., Yamaguchi, T., Nakayama, K. I., Nakauchi, H. & Kamiya, A., Nov 15 2015, In : Developmental Biology. 407, 2, p. 331-343 13 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Maternal TET3 is dispensable for embryonic development but is required for neonatal growth

Tsukada, Y. I., Akiyama, T. & Nakayama, K. I., Oct 28 2015, In : Scientific reports. 5, 15876.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Methylation of Gata3 protein at Arg-261 regulates transactivation of the Il5 gene in T helper 2 cells

Hosokawa, H., Kato, M., Tohyama, H., Tamaki, Y., Endo, Y., Kimura, M. Y., Tumes, D. J., Motohashi, S., Matsumoto, M., Nakayama, K. I., Tanaka, T. & Nakayama, T., May 22 2015, In : Journal of Biological Chemistry. 290, 21, p. 13095-13103 9 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

MTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide

Matsumoto, A., Pasut, A., Matsumoto, M., Yamashita, R., Fung, J., Monteleone, E., Saghatelian, A., Nakayama, K. I., Clohessy, J. G. & Pandolfi, P. P., Jan 12 2017, In : Nature. 541, 7636, p. 228-232 5 p.

Research output: Contribution to journalArticle

190 Citations (Scopus)

mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide.

Matsumoto, A., Pasut, A., Matsumoto, M., Yamashita, R., Fung, J., Monteleone, E., Saghatelian, A., Nakayama, K., Clohessy, J. & Pandolfi, P. P., 2017, In : Nature. 541, 7636, p. 228 5 p., 541.

Research output: Contribution to journalArticle

Noncanonical Pathway for Regulation of CCL2 Expression by an mTORC1-FOXK1 Axis Promotes Recruitment of Tumor-Associated Macrophages

Nakatsumi, H., Matsumoto, M. & Nakayama, K. I., Nov 28 2017, In : Cell Reports. 21, 9, p. 2471-2486 16 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis

Fukushima, H., Shimizu, K., Watahiki, A., Hoshikawa, S., Kosho, T., Oba, D., Sakano, S., Arakaki, M., Yamada, A., Nagashima, K., Okabe, K., Fukumoto, S., Jimi, E., Bigas, A., Nakayama, K. I., Nakayama, K., Aoki, Y., Wei, W. & Inuzuka, H., Nov 16 2017, In : Molecular Cell. 68, 4, p. 645-658.e5

Research output: Contribution to journalArticle

14 Citations (Scopus)

Nuclear–cytoplasmic shuttling protein PP2AB56 contributes to mTORC1-dependent dephosphorylation of FOXK1

Nakatsumi, H., Oka, T., Higa, T., Shirane, M. & Nakayama, K. I., Jul 2018, In : Genes to Cells. 23, 7, p. 599-605 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Peroxisome biogenesis deficiency attenuates the BDNF-TrkB pathway-mediated development of the cerebellum

Abe, Y., Honsho, M., Itoh, R., Kawaguchi, R., Fujitani, M., Fujiwara, K., Hirokane, M., Matsuzaki, T., Nakayama, K., Ohgi, R., Marutani, T., Nakayama, K. I., Yamashita, T. & Fujiki, Y., 2018, In : Life Science Alliance. 1, 6

Research output: Contribution to journalArticle

4 Citations (Scopus)

Phosphorylation of p27Kip1on serine 10 is required for its binding to CRM1 and nuclear export

Ishida, N., Hara, T., Kamura, T., Yoshida, M., Nakayama, K. & Nakayama, K. I., Mar 13 2015, In : Journal of Biological Chemistry. 290, 11, 1 p.

Research output: Contribution to journalComment/debate

4 Citations (Scopus)

Pillars Article: Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes. Science. 1993. 259: 822-825

Shinkai, Y., Koyasu, S., Nakayama, K. I., Murphy, K. M., Loh, D. Y., Reinherz, E. L. & Alt, F. W., Mar 1 2019, In : Journal of immunology (Baltimore, Md. : 1950). 202, 5, p. 1317-1320 4 p.

Research output: Contribution to journalArticle

PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth

Morita, M., Sato, T., Nomura, M., Sakamoto, Y., Inoue, Y., Tanaka, R., Ito, S., Kurosawa, K., Yamaguchi, K., Sugiura, Y., Takizaki, H., Yamashita, Y., Katakura, R., Sato, I., Kawai, M., Okada, Y., Watanabe, H., Kondoh, G., Matsumoto, S., Kishimoto, A. & 12 others, Obata, M., Matsumoto, M., Fukuhara, T., Motohashi, H., Suematsu, M., Komatsu, M., Nakayama, K. I., Watanabe, T., Soga, T., Shima, H., Maemondo, M. & Tanuma, N., Mar 12 2018, In : Cancer Cell. 33, 3, p. 355-367.e7

Research output: Contribution to journalArticle

35 Citations (Scopus)

Potentials of C-C motif chemokine 2–C-C chemokine receptor type 2 blockers including propagermanium as anticancer agents

Yumimoto, K., Sugiyama, S., Mimori, K. & Nakayama, K. I., Jul 2019, In : Cancer Science. 110, 7, p. 2090-2099 10 p.

Research output: Contribution to journalReview article

Open Access
7 Citations (Scopus)

Prevention of cancer dormancy by Fbxw7 ablation eradicates disseminated tumor cells

Shimizu, H., Takeishi, S., Nakatsumi, H. & Nakayama, K. I., 2019, In : JCI Insight. 4, 4, e125138.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Reconstruction of global regulatory network from signaling to cellular functions using phosphoproteomic data

Kawata, K., Yugi, K., Hatano, A., Kokaji, T., Tomizawa, Y., Fujii, M., Uda, S., Kubota, H., Matsumoto, M., Nakayama, K. I. & Kuroda, S., Jan 2019, In : Genes to Cells. 24, 1, p. 82-93 12 p.

Research output: Contribution to journalArticle

Regulation of GATA-binding protein 2 levels via ubiquitin-dependent degradation by Fbw7: Involvement of cyclin B-cyclin-dependent kinase 1-mediated phosphorylation of Thr176 in GATA-binding protein 2

Nakajima, T., Kitagawa, K., Ohhata, T., Sakai, S., Uchida, C., Shibata, K., Minegishi, N., Yumimoto, K., Nakayama, K. I., Masumoto, K., Katou, F., Niida, H. & Kitagawa, M., Apr 17 2015, In : Journal of Biological Chemistry. 290, 16, p. 10368-10381 14 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Role of the Atg9a gene in intrauterine growth and survival of fetal mice

Kojima, T., Yamada, T., Akaishi, R., Furuta, I., Saitoh, T., Nakabayashi, K., Nakayama, K. I., Nakayama, K., Akira, S. & Minakami, H., Sep 1 2015, In : Reproductive Biology. 15, 3, p. 131-138 8 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

SCFFbxw7 ubiquitylates KLF7 for degradation in a manner dependent on GSK-3-mediated phosphorylation

Sugiyama, S., Yumimoto, K., Inoue, I. & Nakayama, K. I., May 2019, In : Genes to Cells. 24, 5, p. 354-365 12 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Sez6l2 regulates phosphorylation of ADD and neuritogenesis

Yaguchi, H., Yabe, I., Takahashi, H., Watanabe, M., Nomura, T., Kano, T., Matsumoto, M., Nakayama, K. I., Watanabe, M. & Hatakeyama, S., Dec 9 2017, In : Biochemical and Biophysical Research Communications. 494, 1-2, p. 234-241 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

SKP2 inactivation suppresses prostate tumorigenesis by mediating JARID1B ubiquitination

Lu, W., Liu, S., Li, B., Xie, Y., Adhiambo, C., Yang, Q., Ballard, B. R., Nakayama, K. I., Matusik, R. J. & Chen, Z., 2015, In : Oncotarget. 6, 2, p. 771-788 18 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Slowly dividing neural progenitors are an embryonic origin of adult neural stem cells

Furutachi, S., Miya, H., Watanabe, T., Kawai, H., Yamasaki, N., Harada, Y., Imayoshi, I., Nelson, M., Nakayama, K. I., Hirabayashi, Y. & Gotoh, Y., Apr 28 2015, In : Nature Neuroscience. 18, 5, p. 657-665 9 p.

Research output: Contribution to journalArticle

127 Citations (Scopus)

SRRM4-dependent neuron-specific alternative splicing of protrudin transcripts regulates neurite outgrowth

Ohnishi, T., Shirane, M. & Nakayama, K. I., Jan 20 2017, In : Scientific reports. 7, 41130.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Structural basis for the assembly of the Ragulator-Rag GTPase complex

Yonehara, R., Nada, S., Nakai, T., Nakai, M., Kitamura, A., Ogawa, A., Nakatsumi, H., Nakayama, K. I., Li, S., Standley, D. M., Yamashita, E., Nakagawa, A. & Okada, M., Dec 1 2017, In : Nature communications. 8, 1, 1625.

Research output: Contribution to journalArticle

21 Citations (Scopus)

The Autism-Related Protein CHD8 Cooperates with C/EBPβ to Regulate Adipogenesis

Kita, Y., Katayama, Y., Shiraishi, T., Oka, T., Sato, T., Suyama, M., Ohkawa, Y., Miyata, K., Oike, Y., Shirane, M., Nishiyama, M. & Nakayama, K. I., May 15 2018, In : Cell Reports. 23, 7, p. 1988-2000 13 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

The pericentromeric protein shugoshin 2 cooperates with HSF1 in heat shock response and RNA Pol II recruitment

Takii, R., Fujimoto, M., Matsumoto, M., Srivastava, P., Katiyar, A., Nakayama, K. I. & Nakai, A., Dec 16 2019, In : EMBO Journal. 38, 24, e102566.

Research output: Contribution to journalArticle

2 Citations (Scopus)

The promise of targeted proteomics for quantitative network biology

Matsumoto, M. & Nakayama, K., Dec 1 2018, In : Current Opinion in Biotechnology. 54, p. 88-97 10 p.

Research output: Contribution to journalReview article

9 Citations (Scopus)

The SCFβ-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis

Shimizu, K., Fukushima, H., Ogura, K., Lien, E. C., Nihira, N. T., Zhang, J., North, B. J., Guo, A., Nagashima, K., Nakagawa, T., Hoshikawa, S., Watahiki, A., Okabe, K., Yamada, A., Toker, A., Asara, J. M., Fukumoto, S., Nakayama, K. I., Nakayama, K., Inuzuka, H. & 1 others, Wei, W., Jan 3 2017, In : Science Signaling. 10, 460

Research output: Contribution to journalArticle

20 Citations (Scopus)