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  • 2019
  • 2017
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Author

  • Keiichi Nakayama
2019

Pillars Article: Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes. Science. 1993. 259: 822-825

Shinkai, Y., Koyasu, S., Nakayama, K. I., Murphy, K. M., Loh, D. Y., Reinherz, E. L. & Alt, F. W., Mar 1 2019, In : Journal of immunology (Baltimore, Md. : 1950). 202, 5, p. 1317-1320 4 p.

Research output: Contribution to journalArticle

A 23 gene–based molecular prognostic score precisely predicts overall survival of breast cancer patients

Shimizu, H. & Nakayama, K. I., Aug 2019, In : EBioMedicine. 46, p. 150-159 10 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)
2015

Fbxw7 suppresses cancer metastasis by inhibiting niche formation

Yumimoto, K. & Nakayama, K. I., Aug 3 2015, In : OncoImmunology. 4, 8

Research output: Contribution to journalArticle

5 Citations (Scopus)

Tissue-specific expression of histone H3 variants diversified after species separation

Maehara, K., Harada, A., Sato, Y., Matsumoto, M., Nakayama, K. I., Kimura, H. & Ohkawa, Y., Sep 17 2015, In : Epigenetics and Chromatin. 8, 1, 35.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Role of the Atg9a gene in intrauterine growth and survival of fetal mice

Kojima, T., Yamada, T., Akaishi, R., Furuta, I., Saitoh, T., Nakabayashi, K., Nakayama, K. I., Nakayama, K., Akira, S. & Minakami, H., Sep 1 2015, In : Reproductive Biology. 15, 3, p. 131-138 8 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2017

mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide.

Matsumoto, A., Pasut, A., Matsumoto, M., Yamashita, R., Fung, J., Monteleone, E., Saghatelian, A., Nakayama, K., Clohessy, J. & Pandolfi, P. P., 2017, In : Nature. 541, 7636, p. 228 5 p., 541.

Research output: Contribution to journalArticle

Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells

Muto, Y., Nishiyama, M., Nita, A., Moroishi, T. & Nakayama, K. I., Jul 17 2017, In : Nature communications. 8, 16114.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2015

F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner

Yumimoto, K., Akiyoshi, S., Ueo, H., Sagara, Y., Onoyama, I., Ueo, H., Ohno, S., Mori, M., Mimori, K. & Nakayama, K. I., Feb 2 2015, In : Journal of Clinical Investigation. 125, 2, p. 621-635 15 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)
2019

Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis

Muto, Y., Moroishi, T., Ichihara, K., Nishiyama, M., Shimizu, H., Eguchi, H., Moriya, K., Koike, K., Mimori, K., Mori, M., Katayama, Y. & Nakayama, K. I., Apr 1 2019, In : Journal of Experimental Medicine. 216, 4, p. 950-965 16 p.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)
2017

FBXL5 inactivation in mouse brain induces aberrant proliferation of neural stem progenitor cells

Yamauchi, T., Nishiyama, M., Moroishi, T., Kawamura, A. & Nakayama, K. I., Apr 1 2017, In : Molecular and cellular biology. 37, 8, e00470-16.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2015

Maternal TET3 is dispensable for embryonic development but is required for neonatal growth

Tsukada, Y. I., Akiyama, T. & Nakayama, K. I., Oct 28 2015, In : Scientific reports. 5, 15876.

Research output: Contribution to journalArticle

21 Citations (Scopus)
2019

Reconstruction of global regulatory network from signaling to cellular functions using phosphoproteomic data

Kawata, K., Yugi, K., Hatano, A., Kokaji, T., Tomizawa, Y., Fujii, M., Uda, S., Kubota, H., Matsumoto, M., Nakayama, K. I. & Kuroda, S., Jan 2019, In : Genes to Cells. 24, 1, p. 82-93 12 p.

Research output: Contribution to journalArticle

2015

Slowly dividing neural progenitors are an embryonic origin of adult neural stem cells

Furutachi, S., Miya, H., Watanabe, T., Kawai, H., Yamasaki, N., Harada, Y., Imayoshi, I., Nelson, M., Nakayama, K. I., Hirabayashi, Y. & Gotoh, Y., Apr 28 2015, In : Nature Neuroscience. 18, 5, p. 657-665 9 p.

Research output: Contribution to journalArticle

127 Citations (Scopus)

Regulation of GATA-binding protein 2 levels via ubiquitin-dependent degradation by Fbw7: Involvement of cyclin B-cyclin-dependent kinase 1-mediated phosphorylation of Thr176 in GATA-binding protein 2

Nakajima, T., Kitagawa, K., Ohhata, T., Sakai, S., Uchida, C., Shibata, K., Minegishi, N., Yumimoto, K., Nakayama, K. I., Masumoto, K., Katou, F., Niida, H. & Kitagawa, M., Apr 17 2015, In : Journal of Biological Chemistry. 290, 16, p. 10368-10381 14 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Liver maturation deficiency in p57Kip2-/- mice occurs in a hepatocytic p57Kip2 expression-independent manner

Yanagida, A., Chikada, H., Ito, K., Umino, A., Kato-Itoh, M., Yamazaki, Y., Sato, H., Kobayashi, T., Yamaguchi, T., Nakayama, K. I., Nakauchi, H. & Kamiya, A., Nov 15 2015, In : Developmental Biology. 407, 2, p. 331-343 13 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

FBXL12-mediated degradation of ALDH3 is essential for trophoblast differentiation during placental development

Nishiyama, M., Nita, A., Yumimoto, K. & Nakayama, K. I., Nov 2015, In : STEM CELLS. 33, 11, p. 3327-3340 14 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2017

Sez6l2 regulates phosphorylation of ADD and neuritogenesis

Yaguchi, H., Yabe, I., Takahashi, H., Watanabe, M., Nomura, T., Kano, T., Matsumoto, M., Nakayama, K. I., Watanabe, M. & Hatakeyama, S., Dec 9 2017, In : Biochemical and Biophysical Research Communications. 494, 1-2, p. 234-241 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp2

Zhang, S., Chen, Q., Liu, Q., Li, Y., Sun, X., Hong, L., Ji, S., Liu, C., Geng, J., Zhang, W., Lu, Z., Yin, Z. Y., Zeng, Y., Lin, K. H., Wu, Q., Li, Q., Nakayama, K., Nakayama, K. I., Deng, X., Johnson, R. L. & 4 others, Zhu, L., Gao, D., Chen, L. & Zhou, D., May 8 2017, In : Cancer Cell. 31, 5, p. 669-684.e7

Research output: Contribution to journalArticle

55 Citations (Scopus)
2015

Phosphorylation of p27Kip1on serine 10 is required for its binding to CRM1 and nuclear export

Ishida, N., Hara, T., Kamura, T., Yoshida, M., Nakayama, K. & Nakayama, K. I., Mar 13 2015, In : Journal of Biological Chemistry. 290, 11, 1 p.

Research output: Contribution to journalComment/debate

4 Citations (Scopus)
2017

NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis

Fukushima, H., Shimizu, K., Watahiki, A., Hoshikawa, S., Kosho, T., Oba, D., Sakano, S., Arakaki, M., Yamada, A., Nagashima, K., Okabe, K., Fukumoto, S., Jimi, E., Bigas, A., Nakayama, K. I., Nakayama, K., Aoki, Y., Wei, W. & Inuzuka, H., Nov 16 2017, In : Molecular Cell. 68, 4, p. 645-658.e5

Research output: Contribution to journalArticle

14 Citations (Scopus)

Noncanonical Pathway for Regulation of CCL2 Expression by an mTORC1-FOXK1 Axis Promotes Recruitment of Tumor-Associated Macrophages

Nakatsumi, H., Matsumoto, M. & Nakayama, K. I., Nov 28 2017, In : Cell Reports. 21, 9, p. 2471-2486 16 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)
2019

Prevention of cancer dormancy by Fbxw7 ablation eradicates disseminated tumor cells

Shimizu, H., Takeishi, S., Nakatsumi, H. & Nakayama, K. I., 2019, In : JCI Insight. 4, 4, e125138.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2015

SKP2 inactivation suppresses prostate tumorigenesis by mediating JARID1B ubiquitination

Lu, W., Liu, S., Li, B., Xie, Y., Adhiambo, C., Yang, Q., Ballard, B. R., Nakayama, K. I., Matusik, R. J. & Chen, Z., 2015, In : Oncotarget. 6, 2, p. 771-788 18 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)
2019

The pericentromeric protein shugoshin 2 cooperates with HSF1 in heat shock response and RNA Pol II recruitment

Takii, R., Fujimoto, M., Matsumoto, M., Srivastava, P., Katiyar, A., Nakayama, K. I. & Nakai, A., Dec 16 2019, In : EMBO Journal. 38, 24, e102566.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2015

Two inhibitory systems and CKIs regulate cell cycle exit of mammalian cardiomyocytes after birth

Tane, S., Okayama, H., Ikenishi, A., Amemiya, Y., Nakayama, K. I. & Takeuchi, T., Oct 16 2015, In : Biochemical and Biophysical Research Communications. 466, 2, p. 147-154 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2019

Potentials of C-C motif chemokine 2–C-C chemokine receptor type 2 blockers including propagermanium as anticancer agents

Yumimoto, K., Sugiyama, S., Mimori, K. & Nakayama, K. I., Jul 2019, In : Cancer Science. 110, 7, p. 2090-2099 10 p.

Research output: Contribution to journalReview article

Open Access
7 Citations (Scopus)
2017

SRRM4-dependent neuron-specific alternative splicing of protrudin transcripts regulates neurite outgrowth

Ohnishi, T., Shirane, M. & Nakayama, K. I., Jan 20 2017, In : Scientific reports. 7, 41130.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2015

FBXO21 mediates the ubiquitylation and proteasomal degradation of EID1

Watanabe, K., Yumimoto, K. & Nakayama, K. I., Aug 1 2015, In : Genes to Cells. 20, 8, p. 667-674 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2017

GRWD1 negatively regulates p53 via the RPL11–MDM2 pathway and promotes tumorigenesis

Kayama, K., Watanabe, S., Takafuji, T., Tsuji, T., Hironaka, K., Matsumoto, M., Nakayama, K. I., Enari, M., Kohno, T., Shiraishi, K., Kiyono, T., Yoshida, K., Sugimoto, N. & Fujita, M., Jan 1 2017, In : EMBO Reports. 18, 1, p. 123-137 15 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2015

Methylation of Gata3 protein at Arg-261 regulates transactivation of the Il5 gene in T helper 2 cells

Hosokawa, H., Kato, M., Tohyama, H., Tamaki, Y., Endo, Y., Kimura, M. Y., Tumes, D. J., Motohashi, S., Matsumoto, M., Nakayama, K. I., Tanaka, T. & Nakayama, T., May 22 2015, In : Journal of Biological Chemistry. 290, 21, p. 13095-13103 9 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2017

MTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide

Matsumoto, A., Pasut, A., Matsumoto, M., Yamashita, R., Fung, J., Monteleone, E., Saghatelian, A., Nakayama, K. I., Clohessy, J. G. & Pandolfi, P. P., Jan 12 2017, In : Nature. 541, 7636, p. 228-232 5 p.

Research output: Contribution to journalArticle

190 Citations (Scopus)
2019

SCFFbxw7 ubiquitylates KLF7 for degradation in a manner dependent on GSK-3-mediated phosphorylation

Sugiyama, S., Yumimoto, K., Inoue, I. & Nakayama, K. I., May 2019, In : Genes to Cells. 24, 5, p. 354-365 12 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Frequent detection of pituitary-derived PRPREs in human prion diseases

Honda, H., Matsumoto, M., Shijo, M., Hamasaki, H., Sadashima, S., Suzuki, S. O., Aishima, S., Kai, K., Nakayama, K. I., Sasagasako, N. & Iwaki, T., Oct 1 2019, In : Journal of neuropathology and experimental neurology. 78, 10, p. 922-929 8 p.

Research output: Contribution to journalArticle

2017

The SCFβ-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis

Shimizu, K., Fukushima, H., Ogura, K., Lien, E. C., Nihira, N. T., Zhang, J., North, B. J., Guo, A., Nagashima, K., Nakagawa, T., Hoshikawa, S., Watahiki, A., Okabe, K., Yamada, A., Toker, A., Asara, J. M., Fukumoto, S., Nakayama, K. I., Nakayama, K., Inuzuka, H. & 1 others, Wei, W., Jan 3 2017, In : Science Signaling. 10, 460

Research output: Contribution to journalArticle

20 Citations (Scopus)

A large-scale targeted proteomics assay resource based on an in vitro human proteome

Matsumoto, M., Matsuzaki, F., Oshikawa, K., Goshima, N., Mori, M., Kawamura, Y., Ogawa, K., Fukuda, E., Nakatsumi, H., Natsume, T., Fukui, K., Horimoto, K., Nagashima, T., Funayama, R., Nakayama, K. & Nakayama, K. I., Feb 28 2017, In : Nature Methods. 14, 3, p. 251-258 8 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Structural basis for the assembly of the Ragulator-Rag GTPase complex

Yonehara, R., Nada, S., Nakai, T., Nakai, M., Kitamura, A., Ogawa, A., Nakatsumi, H., Nakayama, K. I., Li, S., Standley, D. M., Yamashita, E., Nakagawa, A. & Okada, M., Dec 1 2017, In : Nature communications. 8, 1, 1625.

Research output: Contribution to journalArticle

21 Citations (Scopus)