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  • Kensuke Egashira
2019

Nanoparticle incorporating Toll-like receptor 4 inhibitor attenuates myocardial ischaemia-reperfusion injury by inhibiting monocyte-mediated inflammation in mice

Fujiwara, M., Matoba, T., Koga, J-I., Okahara, A., Funamoto, D., Nakano, K., Tsutsui, H. & Egashira, K., Jun 1 2019, In : Cardiovascular research. 115, 7, p. 1244-1255 12 p.

Research output: Contribution to journalArticle

Nanoparticle incorporating Toll-like receptor 4 inhibitor attenuates myocardial ischaemia-reperfusion injury by inhibiting monocyte-mediated inflammation in mice

Fujiwara, M., Matoba, T., Koga, J. I., Okahara, A., Funamoto, D., Nakano, K., Tsutsui, H. & Egashira, K., Jun 1 2019, In : Cardiovascular research. 115, 7, p. 1244-1255 12 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Peroxisome proliferator-activated receptor-gamma targeting nanomedicine promotes cardiac healing after acute myocardial infarction by skewing monocyte/macrophage polarization in preclinical animal models

Tokutome, M., Matoba, T., Nakano, Y., Okahara, A., Fujiwara, M., Koga, J. I., Nakano, K., Tsutsui, H. & Egashira, K., Feb 1 2019, In : Cardiovascular research. 115, 2, p. 419-431 13 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2018

BubR1 insufficiency impairs angiogenesis in aging and in experimental critical limb ischemic mice

Okadome, J., Matsumoto, T., Yoshiya, K., Matsuda, D., Tamada, K., Onimaru, M., Nakano, K., Egashira, K., Yonemitsu, Y. & Maehara, Y., Aug 2018, In : Journal of Vascular Surgery. 68, 2, p. 576-586.e1

Research output: Contribution to journalArticle

1 Citation (Scopus)

Lipid-Lowering Therapy with Ezetimibe Decreases Spontaneous Atherothrombotic Occlusions in a Rabbit Model of Plaque Erosion

Honda, K., Matoba, T., Antoku, Y., Koga, J. I., Ichi, I., Nakano, K., Tsutsui, H. & Egashira, K., Apr 1 2018, In : Arteriosclerosis, thrombosis, and vascular biology. 38, 4, p. 757-771 15 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
4 Citations (Scopus)
3 Citations (Scopus)
2017

Anti-inflammatory Nanomedicine for Cardiovascular Disease

Katsuki, S., Matoba, T., Koga, J-I., Nakano, K. & Egashira, K., 2017, In : Frontiers in cardiovascular medicine. 4, p. 87

Research output: Contribution to journalReview article

Anti-inflammatory Nanomedicine for Cardiovascular Disease

Katsuki, S., Matoba, T., Koga, J. I., Nakano, K. & Egashira, K., Dec 22 2017, In : Frontiers in Cardiovascular Medicine. 4, 87.

Research output: Contribution to journalReview article

Open Access
14 Citations (Scopus)

Ezetimibe in combination with statins ameliorates endothelial dysfunction in coronary arteries after stenting: the CuVIC trial (effect of cholesterol absorption inhibitor usage on target vessel dysfunction after coronary stenting), a multicenter randomized controlled trial

Takase, S., Matoba, T., Nakashiro, S., Mukai, Y., Inoue, S., Oi, K., Higo, T., Katsuki, S., Takemoto, M., Suematsu, N., Eshima, K., Miyata, K., Yamamoto, M., Usui, M., Sadamatsu, K., Satoh, S., Kadokami, T., Hironaga, K., Ichi, I., Todaka, K. & 3 others, Kishimoto, J., Egashira, K. & Sunagawa, K., Feb 2017, In : Arteriosclerosis, thrombosis, and vascular biology. 37, 2, p. 350-358 9 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Marked augmentation of plga nanoparticle-induced metabolically beneficial impact of γ-oryzanol on fuel dyshomeostasis in genetically obese-diabetic ob/ob mice

Kozuka, C., Shimizu-Okabe, C., Takayama, C., Nakano, K., Morinaga, H., Kinjo, A., Fukuda, K., Kamei, A., Yasuoka, A., Kondo, T., Abe, K., Egashira, K. & Masuzaki, H., Feb 9 2017, In : Drug Delivery. 24, 1, p. 558-568 11 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Mutant CCL2 protein coating mitigates wear particle-induced bone loss in a murine continuous polyethylene infusion model

Nabeshima, A., Pajarinen, J., Lin, T. H., Jiang, X., Gibon, E., Córdova, L. A., Loi, F., Lu, L., Jämsen, E., Egashira, K., Yang, F., Yao, Z. & Goodman, S. B., Feb 1 2017, In : Biomaterials. 117, p. 1-9 9 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
19 Citations (Scopus)

Nanoparticle-mediated drug delivery system for atherosclerotic cardiovascular disease

Matoba, T., Koga, J. I., Nakano, K., Egashira, K. & Tsutsui, H., Sep 1 2017, In : Journal of Cardiology. 70, 3, p. 206-211 6 p.

Research output: Contribution to journalReview article

19 Citations (Scopus)

Nanoparticle-mediated endothelial cell-selective drug delivery system

Nakano, K., Koga, J. I. & Egashira, K., Jul 11 2017, Therapeutic Angiogenesis. Springer Singapore, p. 247-266 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2016

Anti-inflammatory nanoparticle for prevention of atherosclerotic vascular diseases

Koga, J. I., Matoba, T. & Egashira, K., Jan 1 2016, In : Journal of atherosclerosis and thrombosis. 23, 7, p. 757-765 9 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
10 Citations (Scopus)

BubR1 Insufficiency Results in Decreased Macrophage Proliferation and Attenuated Atherogenesis in Apolipoprotein E-Deficient Mice

Tanaka, S., Matsumoto, T., Matsubara, Y., Harada, Y., Kyuragi, R., Koga, J. I., Egashira, K., Nakashima, Y., Yonemitsu, Y. & Maehara, Y., Sep 2016, In : Journal of the American Heart Association. 5, 9, e004081.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Critical role of the C5a-activated neutrophils in high-fat diet-induced vascular inflammation

Osaka, M., Ito, S., Honda, M., Inomata, Y., Egashira, K. & Yoshida, M., Feb 19 2016, In : Scientific reports. 6, 21391.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Drp1-dependent mitochondrial autophagy plays a protective role against pressure overload-induced mitochondrial dysfunction and heart failure

Shirakabe, A., Zhai, P., Ikeda, Y., Saito, T., Maejima, Y., Hsu, C. P., Nomura, M., Egashira, K., Levine, B. & Sadoshima, J., Mar 29 2016, In : Circulation. 133, 13, p. 1249-1263 15 p.

Research output: Contribution to journalArticle

112 Citations (Scopus)

Ezetimibe reduced hepatic steatosis induced by dietary oxysterols in nonhuman primates

Deushi, M., Osaka, M., Nakano, K., Osada, K., Egashira, K. & Yoshida, M., Oct 1 2016, In : FEBS Open Bio. 6, 10, p. 1008-1015 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Intratracheal administration of prostacyclin analogue-incorporated nanoparticles ameliorates the development of monocrotaline and sugen-hypoxia-induced pulmonary arterial hypertension

Akagi, S., Nakamura, K., Matsubara, H., Kondo, M., Miura, D., Matoba, T., Egashira, K. & Ito, H., Apr 2016, In : Journal of Cardiovascular Pharmacology. 67, 4, p. 290-298 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Local delivery of mutant CCL2 protein-reduced orthopaedic implant wear particle-induced osteolysis and inflammation in vivo

Jiang, X., Sato, T., Yao, Z., Keeney, M., Pajarinen, J., Lin, T. H., Loi, F., Egashira, K., Goodman, S. & Yang, F., Jan 1 2016, In : Journal of Orthopaedic Research. 34, 1, p. 58-64 7 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Nanoparticle-mediated delivery of irbesartan induces cardioprotection from myocardial ischemia-reperfusion injury by antagonizing monocyte-mediated inflammation

Nakano, Y., Matoba, T., Tokutome, M., Funamoto, D., Katsuki, S., Ikeda, G., Nagaoka, K., Ishikita, A., Nakano, K., Koga, J. I., Sunagawa, K. & Egashira, K., Jul 11 2016, In : Scientific reports. 6, 29601.

Research output: Contribution to journalArticle

30 Citations (Scopus)
26 Citations (Scopus)
Open Access

Nanoparticle-Mediated Targeting of Cyclosporine A Enhances Cardioprotection Against Ischemia-Reperfusion Injury Through Inhibition of Mitochondrial Permeability Transition Pore Opening

Ikeda, G., Matoba, T., Nakano, Y., Nagaoka, K., Ishikita, A., Nakano, K., Funamoto, D., Sunagawa, K. & Egashira, K., Feb 10 2016, In : Scientific reports. 6, 20467.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Pioglitazone-incorporated nanoparticles prevent plaque destabilization and rupture by regulating monocyte/macrophage differentiation in ApoE -/-Mice

Nakashiro, S., Matoba, T., Umezu, R., Koga, J. I., Tokutome, M., Katsuki, S., Nakano, K., Sunagawa, K. & Egashira, K., Mar 1 2016, In : Arteriosclerosis, thrombosis, and vascular biology. 36, 3, p. 491-500 10 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Response by Shirakabe et al to letter regarding article, "Drp1-dependent mitochondrial autophagy plays a protective role against pressure overload-induced mitochondrial dysfunction and heart failure"

Shirakabe, A., Zhai, P., Ikeda, Y., Saito, T., Maejima, Y., Hsu, C. P., Nomura, M., Egashira, K., Levine, B. & Sadoshima, J., Aug 9 2016, In : Circulation. 134, 6, p. e75-e76

Research output: Contribution to journalLetter

1 Citation (Scopus)

The effect of local IL-4 delivery or CCL2 blockade on implant fixation and bone structural properties in a mouse model of wear particle induced osteolysis

Sato, T., Pajarinen, J., Behn, A., Jiang, X., Lin, T. H., Loi, F., Yao, Z., Egashira, K., Yang, F. & Goodman, S. B., Sep 1 2016, In : Journal of Biomedical Materials Research - Part A. 104, 9, p. 2255-2262 8 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)