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  • Kazuhide Inoue
2019

Evidence for detection of rat P2X4 receptor expressed on cells by generating monoclonal antibodies recognizing the native structure

Igawa, T., Kishikawa, S., Abe, Y., Yamashita, T., Nagai, S., Shiroishi, M., Shinozaki, C., Tanaka, H., Tozaki-Saitoh, H., Tsuda, M., Inoue, K. & Ueda, T., Jan 25 2019, In : Purinergic Signalling.

Research output: Contribution to journalArticle

Evidence for detection of rat P2X4 receptor expressed on cells by generating monoclonal antibodies recognizing the native structure

Igawa, T., Kishikawa, S., Abe, Y., Yamashita, T., Nagai, S., Shiroishi, M., Shinozaki, C., Tanaka, H., Tozaki-Saitoh, H., Tsuda, M., Inoue, K. & Ueda, T., Mar 15 2019, In : Purinergic Signalling. 15, 1, p. 27-35 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Hyperactivation of proprioceptors induces microglia-mediated long-lasting pain in a rat model of chronic fatigue syndrome

Yasui, M., Menjyo, Y., Tokizane, K., Shiozawa, A., Tsuda, M., Inoue, K. & Kiyama, H., Mar 30 2019, In : Journal of neuroinflammation. 16, 1, 67.

Research output: Contribution to journalArticle

Open Access

Macrophage centripetal migration drives spontaneous healing process after spinal cord injury

Kobayakawa, K., Ohkawa, Y., Yoshizaki, S., Tamaru, T., Saito, T., Kijima, K., Yokota, K., Hara, M., Kubota, K., Matsumoto, Y., Harimaya, K., Ozato, K., Masuda, T., Tsuda, M., Tamura, T., Inoue, K., Reggie Edgerton, V., Iwamoto, Y., Nakashima, Y. & Okada, S., May 15 2019, In : Science Advances. 5, 5, eaav5086.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Role of P2X3 receptors in scratching behavior in mouse models

Shiratori-Hayashi, M., Hasegawa, A., Toyonaga, H., Andoh, T., Nakahara, T., Kido-Nakahara, M., Furue, M., Kuraishi, Y., Inoue, K., Dong, X. & Tsuda, M., Mar 2019, In : Journal of Allergy and Clinical Immunology. 143, 3, p. 1252-1254.e8

Research output: Contribution to journalArticle

Role of the P2X4 receptor in neuropathic pain

Inoue, K., Aug 2019, In : Current Opinion in Pharmacology. 47, p. 33-39 7 p.

Research output: Contribution to journalReview article

2 Citations (Scopus)

Transcription factor MafB contributes to the activation of spinal microglia underlying neuropathic pain development

Tozaki-Saitoh, H., Masuda, J., Kawada, R., Kojima, C., Yoneda, S., Masuda, T., Inoue, K. & Tsuda, M., Apr 2019, In : GLIA. 67, 4, p. 729-740 12 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2018

A state-of-the-art perspective on microgliopathic pain

Inoue, K., Nov 1 2018, In : Open Biology. 8, 11, 180154.

Research output: Contribution to journalReview article

2 Citations (Scopus)

Astrocytic Ca2+ responses in the spinal dorsal horn by noxious stimuli to the skin

Yoshihara, K., Matsuda, T., Kohro, Y., Tozaki-Saitoh, H., Inoue, K. & Tsuda, M., May 2018, In : Journal of Pharmacological Sciences. 137, 1, p. 101-104 4 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Green Pharma: A new strategy for drug discovery in academia by targeting glial cells and ATP receptors

Yamashita, T., Makoto, T., Saitoh, H. & Inoue, K., Jan 1 2018, In : Yakugaku Zasshi. 138, 8, p. 1027-1031 5 p.

Research output: Contribution to journalReview article

Microglia in neuropathic pain: Cellular and molecular mechanisms and therapeutic potential

Inoue, K. & Tsuda, M., Feb 16 2018, In : Nature Reviews Neuroscience. 19, 3, p. 138-152 15 p.

Research output: Contribution to journalReview article

66 Citations (Scopus)

Optogenetic activation of non-nociceptive aβ fibers induces neuropathic pain-like sensory and emotional behaviors after nerve injury in rats

Tashima, R., Koga, K., Sekine, M., Kanehisa, K., Kohro, Y., Tominaga, K., Matsushita, K., Tozaki-Saitoh, H., Fukazawa, Y., Inoue, K., Yawo, H., Furue, H. & Tsuda, M., Jan 1 2018, In : eNeuro. 5, 1, e0450-17.2018.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Temporal kinetics of microgliosis in the spinal dorsal horn after peripheral nerve injury in rodents

Kohno, K., Kitano, J., Kohro, Y., Tozaki-Saitoh, H., Inoue, K. & Tsuda, M., Jan 1 2018, In : Biological and Pharmaceutical Bulletin. 41, 7, p. 1096-1102 7 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Top-down descending facilitation of spinal sensory excitatory transmission from the anterior cingulate cortex

Chen, T., Taniguchi, W., Chen, Q. Y., Tozaki-Saitoh, H., Song, Q., Liu, R. H., Koga, K., Matsuda, T., Kaito-Sugimura, Y., Wang, J., Li, Z. H., Lu, Y. C., Inoue, K., Tsuda, M., Li, Y. Q., Nakatsuka, T. & Zhuo, M., Dec 1 2018, In : Nature communications. 9, 1, 1886.

Research output: Contribution to journalArticle

24 Citations (Scopus)
2017

Cardiac myofibroblast engulfment of dead cells facilitates recovery after myocardial infarction

Nakaya, M., Watari, K., Tajima, M., Nakaya, T., Matsuda, S., Ohara, H., Nishihara, H., Yamaguchi, H., Hashimoto, A., Nishida, M., Nagasaka, A., Horii, Y., Ono, H., Iribe, G., Inoue, R., Tsuda, M., Inoue, K., Tanaka, A., Kuroda, M., Nagata, S. & 1 others, Kurose, H., Jan 3 2017, In : Journal of Clinical Investigation. 127, 1, p. 383-401 19 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Chemogenetic silencing of GABAergic dorsal horn interneurons induces morphine-resistant spontaneous nocifensive behaviours

Koga, K., Kanehisa, K., Kohro, Y., Shiratori-Hayashi, M., Tozaki-Saitoh, H., Inoue, K., Furue, H. & Tsuda, M., Dec 1 2017, In : Scientific reports. 7, 1, 4739.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Fibromyalgia and microglial TNF-α: Translational research using human blood induced microglia-like cells

Ohgidani, M., Kato, T. A., Hosoi, M., Tsuda, M., Hayakawa, K., Hayaki, C., Iwaki, R., Sagata, N., Hashimoto, R., Inoue, K., Sudo, N. & Kanba, S., Dec 1 2017, In : Scientific reports. 7, 1, 11882.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Neuropharmacological study of atp receptors, especially in the relationship between glia and pain

Inoue, K., Jan 1 2017, In : Yakugaku Zasshi. 137, 5, p. 563-569 7 p.

Research output: Contribution to journalReview article

7 Citations (Scopus)
4 Citations (Scopus)
14 Citations (Scopus)
2016

A novel P2X4 receptor-selective antagonist produces anti-allodynic effect in a mouse model of herpetic pain

Matsumura, Y., Yamashita, T., Sasaki, A., Nakata, E., Kohno, K., Masuda, T., Tozaki-Saitoh, H., Imai, T., Kuraishi, Y., Tsuda, M. & Inoue, K., Aug 31 2016, In : Scientific reports. 6, 32461.

Research output: Contribution to journalArticle

35 Citations (Scopus)

BK channels in microglia are required for morphine-induced hyperalgesia

Hayashi, Y., Morinaga, S., Zhang, J., Satoh, Y., Meredith, A. L., Nakata, T., Wu, Z., Kohsaka, S., Inoue, K. & Nakanishi, H., May 31 2016, In : Nature communications. 7, 11697.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Bone marrow-derived cells in the population of spinal microglia after peripheral nerve injury

Tashima, R., Mikuriya, S., Tomiyama, D., Shiratori-Hayashi, M., Yamashita, T., Kohro, Y., Tozaki-Saitoh, H., Inoue, K. & Tsuda, M., Mar 23 2016, In : Scientific reports. 6, 23701.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Dorsal horn neurons release extracellular ATP in a VNUT-dependent manner that underlies neuropathic pain

Masuda, T., Ozono, Y., Mikuriya, S., Kohro, Y., Tozaki-Saitoh, H., Iwatsuki, K., Uneyama, H., Ichikawa, R., Salter, M. W., Tsuda, M. & Inoue, K., Aug 12 2016, In : Nature communications. 7, 12529.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Duloxetine inhibits microglial P2X4 receptor function and alleviates neuropathic pain after peripheral nerve injury

Yamashita, T., Yamamoto, S., Zhang, J., Kometani, M., Tomiyama, D., Kohno, K., Tozaki-Saitoh, H., Inoue, K. & Tsuda, M., Oct 2016, In : PloS one. 11, 10, e0165189.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia

Koyanagi, S., Kusunose, N., Taniguchi, M., Akamine, T., Kanado, Y., Ozono, Y., Masuda, T., Kohro, Y., Matsunaga, N., Tsuda, M., Salter, M. W., Inoue, K. & Ohdo, S., Oct 14 2016, In : Nature communications. 7, 13102.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease

Matsunaga, N., Ikeda, E., Kakimoto, K., Watanabe, M., Shindo, N., Tsuruta, A., Ikeyama, H., Hamamura, K., Higashi, K., Yamashita, T., Kondo, H., Yoshida, Y., Matsuda, M., Ogino, T., Tokushige, K., Itcho, K., Furuichi, Y., Nakao, T., Yasuda, K., Doi, A. & 7 others, Amamoto, T., Aramaki, H., Tsuda, M., Inoue, K., Ojida, A., Koyanagi, S. & Ohdo, S., Nov 1 2016, In : EBioMedicine. 13, p. 262-273 12 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Neuron-microglia interaction by purinergic signaling in neuropathic pain following neurodegeneration

Tsuda, M. & Inoue, K., May 1 2016, In : Neuropharmacology. 104, p. 76-81 6 p.

Research output: Contribution to journalReview article

41 Citations (Scopus)

Purinergic P2Y6 receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II-induced hypertension

Nishimura, A., Sunggip, C., Tozaki-Saitoh, H., Shimauchi, T., Numaga-Tomita, T., Hirano, K., Ide, T., Boeynaems, J. M., Kurose, H., Tsuda, M., Robaye, B., Inoue, K. & Nishida, M., Jan 19 2016, In : Science Signaling. 9, 411, aac9187.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Role of IRF transcription factor family in regulating reactive phenotype of microglia

Masuda, T., Tsuda, M. & Inoue, K., Jan 1 2016, In : Seikagaku. 88, 1, p. 124-127 4 p.

Research output: Contribution to journalArticle

The frontline of drug creation for neuropathic pain

Inoue, K., Jan 1 2016, In : Japanese Journal of Anesthesiology. 65, p. S136-S142

Research output: Contribution to journalArticle

Transcriptional regulation in microglia and neuropathic pain

Masuda, T., Tsuda, M. & Inoue, K., Apr 1 2016, In : Pain management. 6, 2, p. 91-94 4 p.

Research output: Contribution to journalEditorial

Open Access
3 Citations (Scopus)