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  • 2020
  • 2019
  • 2017
  • 2016

Author

  • Ichiro Ieiri
2020

An updated review of pharmacokinetic drug interactions and pharmacogenetics of statins

Hirota, T., Fujita, Y. & Ieiri, I., 2020, (Accepted/In press) In : Expert Opinion on Drug Metabolism and Toxicology.

Research output: Contribution to journalReview article

Regulation of Organic Anion Transporting Polypeptide 2B1 Expression by MicroRNA in the Human Liver

Tajiri, A., Hirota, T., Kawano, S., Yonamine, A. & Ieiri, I., Aug 3 2020, In : Molecular pharmaceutics. 17, 8, p. 2821-2830 10 p.

Research output: Contribution to journalArticle

2019

Clinical Pharmacokinetics of Anaplastic Lymphoma Kinase Inhibitors in Non-Small-Cell Lung Cancer

Hirota, T., Muraki, S. & Ieiri, I., Apr 4 2019, In : Clinical Pharmacokinetics. 58, 4, p. 403-420 18 p.

Research output: Contribution to journalReview article

7 Citations (Scopus)

Effect of OATP1B1 genotypes on plasma concentrations of endogenous OATP1B1 substrates and drugs, and their association in healthy volunteers

Mori, D., Kashihara, Y., Yoshikado, T., Kimura, M., Hirota, T., Matsuki, S., Maeda, K., Irie, S., Ieiri, I., Sugiyama, Y. & Kusuhara, H., Feb 2019, In : Drug metabolism and pharmacokinetics. 34, 1, p. 78-86 9 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Effects of magnesium oxide on pharmacokinetics of L-dopa/carbidopa and assessment of pharmacodynamic changes by a model-based simulation

Kashihara, Y., Terao, Y., Yoda, K., Hirota, T., Kubota, T., Kimura, M., Matsuki, S., Hirakawa, M., Irie, S. & Ieiri, I., Mar 6 2019, In : European Journal of Clinical Pharmacology. 75, 3, p. 351-361 11 p.

Research output: Contribution to journalArticle

Efficacy of DPP-4 inhibitors, GLP-1 analogues, and SGLT2 inhibitors as add-ons to metformin monotherapy in T2DM patients: a model-based meta-analysis

Inoue, H., Tamaki, Y., Kashihara, Y., Muraki, S., Kakara, M., Hirota, T. & Ieiri, I., Feb 2019, In : British journal of clinical pharmacology. 85, 2, p. 393-402 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Elucidation of N1-methyladenosine as a potential surrogate biomarker for drug interaction studies involving renal organic cation transporters

Miyake, T., Mizuno, T., Takehara, I., Mochizuki, T., Kimura, M., Matsuki, S., Irie, S., Watanabe, N., Kato, Y., Ieiri, I., Maeda, K., Ando, O. & Kusuhara, H., Jan 1 2019, In : Drug Metabolism and Disposition. 47, 11, p. 1270-1280 11 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Identification of drug transporters contributing to oxaliplatin-induced peripheral neuropathy

Fujita, S., Hirota, T., Sakiyama, R., Baba, M. & Ieiri, I., Feb 2019, In : Journal of Neurochemistry. 148, 3, p. 373-385 13 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Microdosing clinical study to clarify pharmacokinetic and pharmacogenetic characteristics of atorvastatin in Japanese hypercholesterolemic patients

Lee, N., Maeda, K., Fukizawa, S., Ieiri, I., Tomaru, A., Akao, H., Takeda, K., Iwadare, M., Niwa, O., Masauji, T., Yamane, N., Kajinami, K., Kusuhara, H. & Sugiyama, Y., Dec 2019, In : Drug metabolism and pharmacokinetics. 34, 6, p. 387-395 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Pharmacokinetics, Pharmacodynamics, and Safety of E6011, a Novel Humanized Antifractalkine (CX3CL1) Monoclonal Antibody: A Randomized, Double-Blind, Placebo-Controlled Single-Ascending-Dose Study

Tabuchi, H., Katsurabara, T., Mori, M., Aoyama, M., Obara, T., Yasuda, N., Kawano, T., Imai, T., Ieiri, I. & Kumagai, Y., May 2019, In : Journal of Clinical Pharmacology. 59, 5, p. 688-701 14 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Population Pharmacokinetic Analysis of Phenytoin after Intravenous Administration of Fosphenytoin in Adult and Elderly Epileptic Patients

Higuchi, K., Yamashita, D., Kashihara, Y., Kakara, M., Hirota, T., Hirakawa, M. & Ieiri, I., Oct 1 2019, In : Therapeutic drug monitoring. 41, 5, p. 674-680 7 p.

Research output: Contribution to journalArticle

The association of tobacco use with prescription of muscle relaxants, benzodiazepines, and opioid analgesics for non-cancer pain

Takaki, H., Ieiri, I., Shibuta, H., Onozuka, D. & Hagihara, A., Jan 9 2019, In : American Journal on Addictions.

Research output: Contribution to journalArticle

2017

Characterization of ADME gene variation in 21 populations by exome sequencing

Hovelson, D. H., Xue, Z., Zawistowski, M., Ehm, M. G., Harris, E. C., Stocker, S. L., Gross, A. S., Jang, I. J., Ieiri, I., Lee, J. E., Cardon, L. R., Chissoe, S. L., Abecasis, G. & Nelson, M. R., 2017, In : Pharmacogenetics and Genomics. 27, 3, p. 89-100 12 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Epigenetic regulation of drug transporter expression in human tissues

Hirota, T., Tanaka, T., Takesue, H. & Ieiri, I., Jan 2 2017, In : Expert Opinion on Drug Metabolism and Toxicology. 13, 1, p. 19-30 12 p.

Research output: Contribution to journalReview article

6 Citations (Scopus)

Involvement of Organic Cation Transporters in the Kinetics of Trimethylamine N-oxide

Miyake, T., Mizuno, T., Mochizuki, T., Kimura, M., Matsuki, S., Irie, S., Ieiri, I., Maeda, K. & Kusuhara, H., Sep 2017, In : Journal of Pharmaceutical Sciences. 106, 9, p. 2542-2550 9 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Small-Dosing Clinical Study: Pharmacokinetic, Pharmacogenomic (SLCO2B1 and ABCG2), and Interaction (Atorvastatin and Grapefruit Juice) Profiles of 5 Probes for OATP2B1 and BCRP

Kashihara, Y., Ieiri, I., Yoshikado, T., Maeda, K., Fukae, M., Kimura, M., Hirota, T., Matsuki, S., Irie, S., Izumi, N., Kusuhara, H. & Sugiyama, Y., Sep 2017, In : Journal of Pharmaceutical Sciences. 106, 9, p. 2688-2694 7 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
2016

Chapter 5: Pharmacogenomics of Drug Transporters: Clinical Implications

Ieiri, I., Jan 1 2016, Privileged Scaffolds in Medicinal Chemistry: Design, Synthesis, Evaluation. 55 ed. Royal Society of Chemistry, p. 114-142 29 p. (RSC Drug Discovery Series; vol. 2016-January, no. 55).

Research output: Chapter in Book/Report/Conference proceedingChapter

Circulating intestine-derived exosomal miR-328 in plasma, a possible biomarker for estimating BCRP function in the human intestines

Gotanda, K., Hirota, T., Saito, J., Fukae, M., Egashira, Y., Izumi, N., Deguchi, M., Kimura, M., Matsuki, S., Irie, S. & Ieiri, I., Aug 30 2016, In : Scientific reports. 6, 32299.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Clarification of the mechanism of clopidogrel-mediated drug-drug interaction in a clinical cassette small-dose study and its prediction based on in vitro information

Kim, S. J., Yoshikado, T., Ieiri, I., Maeda, K., Kimura, M., Irie, S., Kusuhara, H. & Sugiyama, Y., Oct 2016, In : Drug Metabolism and Disposition. 44, 10, p. 1622-1632 11 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Population pharmacodynamic analysis of hemoglobin A1c-lowering effects by adding treatment of DPP-4 inhibitors (sitagliptin) in type 2 diabetes mellitus patients based on electronic medical records

Kakara, M., Nomura, H., Ezaki, M., Fukae, M., Hirota, T., Matsubayashi, S., Hirakawa, M. & Ieiri, I., Sep 1 2016, In : Journal of Diabetes and Its Complications. 30, 7, p. 1282-1286 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Population pharmacokinetic–pharmacodynamic modeling and model-based prediction of docetaxel-induced neutropenia in Japanese patients with non-small cell lung cancer

Fukae, M., Shiraishi, Y., Hirota, T., Sasaki, Y., Yamahashi, M., Takayama, K., Nakanishi, Y. & Ieiri, I., Nov 1 2016, In : Cancer chemotherapy and pharmacology. 78, 5, p. 1013-1023 11 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)