A β-hairpin peptide with pH-controlled affinity for tumor cells

Shin Nosuke Nishimura, Kei Nishida, Masaru Tanaka

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Considering that the pH in the tumor microenvironment is dysregulated, we designed a β-hairpin peptide (SSRFEWEFESSDPRGDPSSRFEWEFESS). The configuration of the peptide switched from a flexible linear to a rigid loop structure under weakly acidic conditions. The peptide internalized by tumor cells increased significantly under weakly acidic conditions.

Original languageEnglish
Pages (from-to)505-508
Number of pages4
JournalChemical Communications
Volume58
Issue number4
DOIs
Publication statusPublished - Jan 14 2022

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Fingerprint

Dive into the research topics of 'A β-hairpin peptide with pH-controlled affinity for tumor cells'. Together they form a unique fingerprint.

Cite this