A basic study of determination matrix metalloproteinase-3 and carbohydrate in rheumatoid factor in serum for diagnosis of rheumatoid arthritis

Michiyo Urata, Nobuko Nakamura, Sachiko Kinoshita, Yuzo Kayamori, Naotaka Hamasaki

Research output: Contribution to journalArticle

Abstract

The examination of rheumatoid factor (RF), one of the diagnostic marker of rheumatoid arthritis (RA), showed negative about 25% of patients with RA. We analyzed a matrix metalloproteinase-3 (MMP-3) and a carbohydrate in rheumatoid factor (CA.RF) for diagnosis of RA: the former is used the kit "Panaclear MMP-3[Plate]" and the latter is used the kit "Picolumi CA.RF". The basic study of these reagents showed satisfactory results. In 73.3% of seronegative RA showed positive on both MMP-3 and CA.RF levels in serum, respectively. We found that these examinations might be useful for diagnosis of RA, especially during seronegative RA.

Original languageEnglish
Pages (from-to)745-750
Number of pages6
JournalRinsho byori. The Japanese journal of clinical pathology
Volume51
Issue number8
Publication statusPublished - Jan 1 2003

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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