A brain region-specific gene product Lhx6.1 interacts with Ldb1 through tandem LIM-domains

Naoki Kimura, Masaya Ueno, Kinichi Nakashima, Tetsuya Taga

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

LIM-homeodomain (LHX) transcription factors play critical roles in cell fate determination during development, in particular, in CNS. The transcriptional activity of several LHX proteins is postulated to be regulated by interaction with an LIM-domain binding protein, Ldb1. We have now identified a novel LHX molecule, termed Lhx6.1, that is closely related to a recently reported Lhx6 molecule. The Lhx6.1 transcript is found in several restricted regions in the developing CNS, mostly within the embryonic forebrain. We further show that Lhx6.1 interacts with Ldb1 through tandem LIM-domains, implying transcriptional regulation of Lhx6.1 by Ldb1.

Original languageEnglish
Pages (from-to)180-187
Number of pages8
JournalJournal of Biochemistry
Volume126
Issue number1
DOIs
Publication statusPublished - Jan 1 1999
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

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