A broadly applicable copper reagent for trifluoromethylations and perfluoroalkylations of aryl iodides and bromides

Hiroyuki Morimoto, Tetsu Tsubogo, Nichole D. Litvinas, John F. Hartwig

Research output: Contribution to journalArticlepeer-review

367 Citations (Scopus)

Abstract

(Chemical Presented) Well compatible: The trifluoromethylations and perfluoroalkylations of aryl iodides and some aryl bromides with trifluoromethyl and perfluoroalkylcopper(I) phenanthroline complexes occur with broad scope at 25-50 8C (see scheme). The trifluoromethyl complex is prepared from inexpensive reagents and can be used in situ or isolated. The reactions tolerate a range of substituents and also occur with heteroaromatic systems.

Original languageEnglish
Pages (from-to)3793-3798
Number of pages6
JournalAngewandte Chemie - International Edition
Volume50
Issue number16
DOIs
Publication statusPublished - Apr 11 2011

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

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