A case of acute disseminated encephalomyelitis associated with Epstein-Barr virus reactivation during infliximab therapy

Maki Ueda, Takahisa Tateishi, Hiroshi Shigeto, Ryo Yamasaki, Yasumasa Ohyagi, Jun Ichi Kira

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A 31-year-old woman with Crohn's disease that had been refractory to drug therapies for 7 years had been treated with infliximab for a year. She was admitted to our hospital because of truncal ataxia and bulbar palsy, which presented following aseptic meningitis. Neurological examination revealed abducens paresis on the left, gaze-evoked nystagmus on upward and rightward gaze, right facial muscle weakness, bulbar palsy, weakness in the right upper extremity, limb ataxia predominantly on the left side, diminished sense in the lower extremities predominantly on the right, diffuse hyperreflexia in all extremities. Antibodies to Epstein-Barr virus (EBV) in serum demonstrated a previous infection pattern, and EBV-DNA was detected in peripheral blood and cerebrospinal fluid (CSF) by PCR. CSF analysis indicated pleocytosis, an elevation of IgG index and a marked increase in the level of myelin basic protein. FLAIR MRI images revealed multiple hyperintense lesions in the brainstem, subcortical white matter, and cervical spinal cord. Accordingly, we diagnosed her as having acute disseminated encephalomyelitis (ADEM), associated with reactivated EBV infection. Although gancyclovir, plasma exchange and intravenous high dose immunoglobulins were not effective, repetitive use of methylprednisolone pulse therapy alleviated her symptoms and the abnormal MRI lesions. It is suggested that the reactivated EBV infection caused by infliximab may have contributed to the development of ADEM in this case. Besides the demyelinating event directly induced by anti-TNF-α therapy, we should pay attention to the occurrence of reactivated EBV-triggered ADEM during anti-TNF-α therapy.

Original languageEnglish
Pages (from-to)461-466
Number of pages6
JournalClinical Neurology
Volume50
Issue number7
DOIs
Publication statusPublished - Jul 2010

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Acute Disseminated Encephalomyelitis
Epstein-Barr Virus Infections
Progressive Bulbar Palsy
Human Herpesvirus 4
Ataxia
Upper Extremity
Cerebrospinal Fluid
Facial Muscles
Aseptic Meningitis
Abnormal Reflexes
Ganciclovir
Plasma Exchange
Myelin Basic Protein
Leukocytosis
Muscle Weakness
Methylprednisolone
Neurologic Examination
Paresis
Crohn Disease
Brain Stem

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

A case of acute disseminated encephalomyelitis associated with Epstein-Barr virus reactivation during infliximab therapy. / Ueda, Maki; Tateishi, Takahisa; Shigeto, Hiroshi; Yamasaki, Ryo; Ohyagi, Yasumasa; Kira, Jun Ichi.

In: Clinical Neurology, Vol. 50, No. 7, 07.2010, p. 461-466.

Research output: Contribution to journalArticle

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