A case of acute hepatitis a infection with genotype iiia that was responsive to high-dose corticosteroid therapy

Kazufumi Dohmen, Hirofumi Tanaka, Shin Ya Onohara, Koji Ishii, Kazuaki Takahashi, Shinji Shimoda

Research output: Contribution to journalArticle

Abstract

A 64-year-old man with complaints of general fatigue and high fever was admitted because of liver dysfunction. He had a history of eating raw oysters 2 weeks before. His laboratory data on hospital day 1 were as follows: total bilirubin (TB), 1.16 mg/dl; aspartate aminotransferase (AST), 1870 IU/L; alanine aminotransferase (ALT), 1042 IU/L and PT activity, 77.6%. On the second day, his liver injury worsened rapidly on the basis of the following values: TB, 3.02 mg/dl; AST, 5400 IU/L; ALT, 2945 IU/L and PT activity, 47.5%. The risk of hepatic encephalopathy development in acute liver injury on the second day was calculated 13.5%; therefore, high-dose corticosteroid therapy was administered. The liver injury improved. Later, the etiology of liver injury was found to be hepatitis A infection. Genotype IIIA is often found in South Asia and is different from the genotype IIIA clusters found in the outbreak in Korea.

Original languageEnglish
Pages (from-to)481-487
Number of pages7
JournalActa Hepatologica Japonica
Volume59
Issue number9
DOIs
Publication statusPublished - Jan 1 2018

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Hepatitis
Adrenal Cortex Hormones
Genotype
Liver
Wounds and Injuries
Aspartate Aminotransferases
Infection
Alanine Transaminase
Bilirubin
Alanine
Ostreidae
Hepatitis A
Hepatic Encephalopathy
Therapeutics
Korea
Fatigue
Disease Outbreaks
Liver Diseases
Fever
Eating

All Science Journal Classification (ASJC) codes

  • Hepatology

Cite this

A case of acute hepatitis a infection with genotype iiia that was responsive to high-dose corticosteroid therapy. / Dohmen, Kazufumi; Tanaka, Hirofumi; Onohara, Shin Ya; Ishii, Koji; Takahashi, Kazuaki; Shimoda, Shinji.

In: Acta Hepatologica Japonica, Vol. 59, No. 9, 01.01.2018, p. 481-487.

Research output: Contribution to journalArticle

Dohmen, Kazufumi ; Tanaka, Hirofumi ; Onohara, Shin Ya ; Ishii, Koji ; Takahashi, Kazuaki ; Shimoda, Shinji. / A case of acute hepatitis a infection with genotype iiia that was responsive to high-dose corticosteroid therapy. In: Acta Hepatologica Japonica. 2018 ; Vol. 59, No. 9. pp. 481-487.
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