A case of advanced pancreatic cancer responding to combination chemotherapy with the individual maximum repeatable dose of gemcitabine and oral S-1

Chinatsu Fujimoto, Yuji Maruyama, Yuusuke Niina, Nao Fujimori, Toshihiko Sumii, Akihiro Funakoshi

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The patient was a 70-year-old man with metastatic pancreatic cancer. After he received combination chemotherapy with gemcitabine and oral S-1 on day 1, he experienced severe general fatigue, anorexia and nausea. Then we changed the dose of gemcitabine from 1,000 mg/m(2) 2 to 500 mg/m(2) according to the criteria for an individual maximum repeatable dose (iMRD) determination method on day 8. His general condition recovered, and treatment schedule of gemcitabine with S-1 was continued sequentially at an outpatient clinic. His tumor marker levels, and the sizes of primary pancreatic tumor and liver metastatic lesions remarkably decreased. Partial response has been obtained for 7 months.

Original languageEnglish
Pages (from-to)1013-1016
Number of pages4
JournalGan to kagaku ryoho. Cancer & chemotherapy
Issue number6
Publication statusPublished - Jan 1 2008


All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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