A case of advanced rectal cancer responding to oral UFT and Leucovorin-based preoperative chemoradiation therapy

Kotaro Shibahara; Takahiro Hirazuka; Manabu Yamamoto; Mizuki Ninomiya; Kojiro Mashino; Kyuzo Fuji; Tetsuo Ikeda; Tadashi Kahno

A case of advanced rectal cancer responding to oral UFT and Leucovorin-based preoperative chemoradiation therapy

Kotaro Shibahara, Takahiro Hirazuka, Manabu Yamamoto, Mizuki Ninomiya, Kojiro Mashino, Kyuzo Fuji, Tetsuo Ikeda, Tadashi Kahno

Department of Advanced Medicine and Innovative Technology

Research output: Contribution to journal › Article › peer-review

Abstract

We report a case of a 44-year-old male with advanced lower rectal cancer that showed a significant effect after preoperative chemoradiation therapy. Preoperative radiation and chemotherapy included whole pelvis irradiation (30 Gy in total), oral UFT (500 mg/day), and Leucovorin (75 mg/day) was administered daily for 4 weeks. Consequently, the patient underwent a total pelvic exenteration with lymph node dissection (D 3). Histopathological findings showed: invasion to peritoneum(Ai); stage IIIa with n(-); and histological grading, Grade 2. Preoperative chemoradiation therapy appears to be effective for locally advanced lower rectal cancer.

Original language	English
Pages (from-to)	1481-1483
Number of pages	3
Journal	Gan to kagaku ryoho. Cancer & chemotherapy
Volume	33
Issue number	10
Publication status	Published - Jan 1 2006

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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abstract = "We report a case of a 44-year-old male with advanced lower rectal cancer that showed a significant effect after preoperative chemoradiation therapy. Preoperative radiation and chemotherapy included whole pelvis irradiation (30 Gy in total), oral UFT (500 mg/day), and Leucovorin (75 mg/day) was administered daily for 4 weeks. Consequently, the patient underwent a total pelvic exenteration with lymph node dissection (D 3). Histopathological findings showed: invasion to peritoneum(Ai); stage IIIa with n(-); and histological grading, Grade 2. Preoperative chemoradiation therapy appears to be effective for locally advanced lower rectal cancer.",

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AU - Shibahara, Kotaro

AU - Hirazuka, Takahiro

AU - Yamamoto, Manabu

AU - Ninomiya, Mizuki

AU - Mashino, Kojiro

AU - Fuji, Kyuzo

AU - Ikeda, Tetsuo

AU - Kahno, Tadashi

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N2 - We report a case of a 44-year-old male with advanced lower rectal cancer that showed a significant effect after preoperative chemoradiation therapy. Preoperative radiation and chemotherapy included whole pelvis irradiation (30 Gy in total), oral UFT (500 mg/day), and Leucovorin (75 mg/day) was administered daily for 4 weeks. Consequently, the patient underwent a total pelvic exenteration with lymph node dissection (D 3). Histopathological findings showed: invasion to peritoneum(Ai); stage IIIa with n(-); and histological grading, Grade 2. Preoperative chemoradiation therapy appears to be effective for locally advanced lower rectal cancer.

AB - We report a case of a 44-year-old male with advanced lower rectal cancer that showed a significant effect after preoperative chemoradiation therapy. Preoperative radiation and chemotherapy included whole pelvis irradiation (30 Gy in total), oral UFT (500 mg/day), and Leucovorin (75 mg/day) was administered daily for 4 weeks. Consequently, the patient underwent a total pelvic exenteration with lymph node dissection (D 3). Histopathological findings showed: invasion to peritoneum(Ai); stage IIIa with n(-); and histological grading, Grade 2. Preoperative chemoradiation therapy appears to be effective for locally advanced lower rectal cancer.

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A case of advanced rectal cancer responding to oral UFT and Leucovorin-based preoperative chemoradiation therapy

Abstract

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