A case of advanced rectal cancer responding to oral UFT and Leucovorin-based preoperative chemoradiation therapy

Kotaro Shibahara, Takahiro Hirazuka, Manabu Yamamoto, Mizuki Ninomiya, Kojiro Mashino, Kyuzo Fuji, Tetsuo Ikeda, Tadashi Kahno

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Abstract

We report a case of a 44-year-old male with advanced lower rectal cancer that showed a significant effect after preoperative chemoradiation therapy. Preoperative radiation and chemotherapy included whole pelvis irradiation (30 Gy in total), oral UFT (500 mg/day), and Leucovorin (75 mg/day) was administered daily for 4 weeks. Consequently, the patient underwent a total pelvic exenteration with lymph node dissection (D 3). Histopathological findings showed: invasion to peritoneum(Ai); stage IIIa with n(-); and histological grading, Grade 2. Preoperative chemoradiation therapy appears to be effective for locally advanced lower rectal cancer.

Original languageEnglish
Pages (from-to)1481-1483
Number of pages3
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume33
Issue number10
Publication statusPublished - Jan 1 2006

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All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Shibahara, K., Hirazuka, T., Yamamoto, M., Ninomiya, M., Mashino, K., Fuji, K., ... Kahno, T. (2006). A case of advanced rectal cancer responding to oral UFT and Leucovorin-based preoperative chemoradiation therapy. Gan to kagaku ryoho. Cancer & chemotherapy, 33(10), 1481-1483.