A case of an inflammatory myofibroblastic tumor in the lung which expressed TPM3-ALK gene fusion

Yoshiaki Kinoshita, T. Tajiri, S. Ieiri, K. Nagata, Tomoaki Taguchi, S. Suita, K. Yamazaki, I. Yoshino, Yoshihiko Maehara, K. Kohashi, H. Yamamoto, Y. Oda, M. Tsuneyoshi

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

We herein describe a 4-year-old boy who after being treated for pneumonia showed an abnormal shadow at the hilus of the right lung on chest X-rays with continued inflammatory findings in his laboratory data. CT and MR investigations suggested the existence of a neoplasm at that site. An open biopsy was thus performed for a definite diagnosis. The histological findings and the expression of TPM3-ALK fusion gene confirmed a diagnosis of an inflammatory myofibroblastic tumor. A right upper and middle lobectomy including the tumor was thus performed for a complete resection. In addition to the histological diagnosis, the detection of the tumor specific fusion gene provided objective evidence in making a diagnosis.

Original languageEnglish
Pages (from-to)595-599
Number of pages5
JournalPediatric surgery international
Volume23
Issue number6
DOIs
Publication statusPublished - Jun 2007

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Surgery

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