A case of an inflammatory myofibroblastic tumor in the lung which expressed TPM3-ALK gene fusion

Y. Kinoshita, T. Tajiri, S. Ieiri, K. Nagata, T. Taguchi, S. Suita, K. Yamazaki, I. Yoshino, Y. Maehara, K. Kohashi, H. Yamamoto, Y. Oda, M. Tsuneyoshi

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Abstract

We herein describe a 4-year-old boy who after being treated for pneumonia showed an abnormal shadow at the hilus of the right lung on chest X-rays with continued inflammatory findings in his laboratory data. CT and MR investigations suggested the existence of a neoplasm at that site. An open biopsy was thus performed for a definite diagnosis. The histological findings and the expression of TPM3-ALK fusion gene confirmed a diagnosis of an inflammatory myofibroblastic tumor. A right upper and middle lobectomy including the tumor was thus performed for a complete resection. In addition to the histological diagnosis, the detection of the tumor specific fusion gene provided objective evidence in making a diagnosis.

Original languageEnglish
Pages (from-to)595-599
Number of pages5
JournalPediatric surgery international
Volume23
Issue number6
DOIs
Publication statusPublished - Jun 1 2007

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All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Surgery

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