A case of anti-neurofascin 155 antibody-positive combined central and peripheral demyelination successfully treated with plasma exchange

Mikito Shimizu, Tohru Koda, Yuji Nakatsuji, Hidenori Ogata, Jun ichi Kira, Hideki Mochizuki

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A 21-year-old man was admitted to our hospital in June 2015. He felt paresthesia of toes in April 2015, which had been spreading upward, and he became difficult to walk in June. Nerve conduction study showed peripheral demyelinating neuropathy that met the diagnostic criteria for chronic inflammatory demyelinating polyneuropathy (CIDP), and the cerebrospinal fluid (CSF) examination revealed the remarkably increased protein level. In addition, magnetic resonance imaging of his brain showed a few plaques in white matter, so he was finally diagnosed with combined central and peripheral demyelination (CCPD). Moreover, anti-neurofascin155 (NF155) antibodies assayed in his serum and CSF turned out to be positive. Although he was treated with intravenous immunoglobulin and intravenous methylprednisolone, his symptoms were not ameliorated. However, plasma exchange therapy was apparently effective, and the titer of anti-NF155 antibody was reduced. Recently, the number of case reports of CIDP with CNS lesions has gradually been increasing, while the information about the diagnosis and the treatment responses are not enough. Thus, we reported our case with CCPD who was successfully treated with plasma exchange.

Original languageEnglish
Pages (from-to)41-44
Number of pages4
JournalClinical Neurology
Volume57
Issue number1
DOIs
Publication statusPublished - Jan 1 2017

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Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Plasma Exchange
Demyelinating Diseases
Cerebrospinal Fluid
Anti-Idiotypic Antibodies
Antibodies
Paresthesia
Intravenous Immunoglobulins
Neural Conduction
Methylprednisolone
Toes
Peripheral Nervous System Diseases
Magnetic Resonance Imaging
Brain
Therapeutics
Serum
Proteins
White Matter

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

A case of anti-neurofascin 155 antibody-positive combined central and peripheral demyelination successfully treated with plasma exchange. / Shimizu, Mikito; Koda, Tohru; Nakatsuji, Yuji; Ogata, Hidenori; Kira, Jun ichi; Mochizuki, Hideki.

In: Clinical Neurology, Vol. 57, No. 1, 01.01.2017, p. 41-44.

Research output: Contribution to journalArticle

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