A case of anti-SS-A and anti-SS-B antibody-positive lipoatropy

Yumiko Arao, Futoshi Kohda, Kyoko Nakamura, Manabu Hamada, Yoichi Moroi, Kazunori Urabe, Masutaka Furue

Research output: Contribution to journalArticlepeer-review


A 66-year-old woman noticed cutaneous concavities of 2-3 cm in diameter on her upper arms in 1999. Similar lesions gradually developed on her forearms, chest, and back. Anti-SS-A and anti-SS-B antibodies were positive. The histopathological examination revealed a degeneration of lipocytes with infiltration of lymphocytes and macrophages. An immunofluorescence microscopic study demonstrated no deposition of immunoglobulin and complement in the basement membrane zone. These findings led to the diagnosis of the inflammatory type of localized lipoatrophy. This clinical entity is equivalent to lipoatrophic connective tissue panniculitis. The pathogenesis is unknown; however, an autoimmune mechanism may be involved.

Original languageEnglish
Pages (from-to)113-115
Number of pages3
JournalNishinihon Journal of Dermatology
Issue number2
Publication statusPublished - 2005

All Science Journal Classification (ASJC) codes

  • Dermatology


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