Abstract
A 53-year-old Japanese man was found to have a liver dysfunction with a total bilirubin of 3.3 mg/dl, ALT 724 IU/l, alkaline phosphatase 568IU/l with an elevation of serum IgM while serum levels of IgG, antinuclear antibody (ANA) and anti-mitochondrial antibody (AMA) showed normal. Primary biliary cirrhosis (PBC) was suspected at that time, however, he left the hospital by self-determination. Five years later, he developed liver cirrhosis with jaundice, ascites and skin pigmentation and sclerosis. Antinuclear antibody, negative 5 years before, was now positive at 1: more than 2560. Serum IgG and IgM were elevated. Anti-mitochondrial antibody M2 component, and liver-kidney microsome (LKM)-1 antibody, double strand DNA antibody, platelet-associated IgG, direct-, indirect Coombs tests were also positive. Liver histology revealed cirrhosis. He was diagnosed as having AIH/PBC overlap syndrome due to serologic features. Sequential changes of the titers of several antibodies, laboratory characteristics and clinical symptoms within short durations are discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 513-520 |
| Number of pages | 8 |
| Journal | Acta Hepatologica Japonica |
| Volume | 51 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Nov 8 2010 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Hepatology
Cite this
A case of autoimmune hepatitis/primary biliary cirrhosis overlap syndrome progressing rapidly to cirrhosis with skin pigmentation and various immunological characteristics. / Dohmen, Kazufumi; Tanaka, Hirofumi; MasatoraHaruno; Aishima, Shin Ichi; Shimoda, Shinji.
In: Acta Hepatologica Japonica, Vol. 51, No. 9, 08.11.2010, p. 513-520.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A case of autoimmune hepatitis/primary biliary cirrhosis overlap syndrome progressing rapidly to cirrhosis with skin pigmentation and various immunological characteristics
AU - Dohmen, Kazufumi
AU - Tanaka, Hirofumi
AU - MasatoraHaruno,
AU - Aishima, Shin Ichi
AU - Shimoda, Shinji
PY - 2010/11/8
Y1 - 2010/11/8
N2 - A 53-year-old Japanese man was found to have a liver dysfunction with a total bilirubin of 3.3 mg/dl, ALT 724 IU/l, alkaline phosphatase 568IU/l with an elevation of serum IgM while serum levels of IgG, antinuclear antibody (ANA) and anti-mitochondrial antibody (AMA) showed normal. Primary biliary cirrhosis (PBC) was suspected at that time, however, he left the hospital by self-determination. Five years later, he developed liver cirrhosis with jaundice, ascites and skin pigmentation and sclerosis. Antinuclear antibody, negative 5 years before, was now positive at 1: more than 2560. Serum IgG and IgM were elevated. Anti-mitochondrial antibody M2 component, and liver-kidney microsome (LKM)-1 antibody, double strand DNA antibody, platelet-associated IgG, direct-, indirect Coombs tests were also positive. Liver histology revealed cirrhosis. He was diagnosed as having AIH/PBC overlap syndrome due to serologic features. Sequential changes of the titers of several antibodies, laboratory characteristics and clinical symptoms within short durations are discussed.
AB - A 53-year-old Japanese man was found to have a liver dysfunction with a total bilirubin of 3.3 mg/dl, ALT 724 IU/l, alkaline phosphatase 568IU/l with an elevation of serum IgM while serum levels of IgG, antinuclear antibody (ANA) and anti-mitochondrial antibody (AMA) showed normal. Primary biliary cirrhosis (PBC) was suspected at that time, however, he left the hospital by self-determination. Five years later, he developed liver cirrhosis with jaundice, ascites and skin pigmentation and sclerosis. Antinuclear antibody, negative 5 years before, was now positive at 1: more than 2560. Serum IgG and IgM were elevated. Anti-mitochondrial antibody M2 component, and liver-kidney microsome (LKM)-1 antibody, double strand DNA antibody, platelet-associated IgG, direct-, indirect Coombs tests were also positive. Liver histology revealed cirrhosis. He was diagnosed as having AIH/PBC overlap syndrome due to serologic features. Sequential changes of the titers of several antibodies, laboratory characteristics and clinical symptoms within short durations are discussed.
UR - http://www.scopus.com/inward/record.url?scp=78049391699&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78049391699&partnerID=8YFLogxK
U2 - 10.2957/kanzo.51.513
DO - 10.2957/kanzo.51.513
M3 - Article
AN - SCOPUS:78049391699
VL - 51
SP - 513
EP - 520
JO - Acta Hepatologica Japonica
JF - Acta Hepatologica Japonica
SN - 0451-4203
IS - 9
ER -