A case of Borrelia brainstem encephalitis presenting with severe dysphagia

Yuji Kawano, Hiroshi Shigeto, Yoshimasa Shiraishi, Yasumasa Ohyagi, Jun-Ichi Kira

Research output: Contribution to journalArticle

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Abstract

We report the case of a 30-year-old man who developed severe dysphagia owing to neuroborreliosis. He showed dysphagia, diplopia, hiccups, and walking difficulty Neurological examination revealed mild disturbance of consciousness, diplopia on left lateral gaze, left-side-dominant blephaloptosis, gaze-evoked horizontal nystagmus on left lateral gaze, mild bilateral muscle weakness, palatoplegia, dysphagia, dysarthria, and truncal ataxia. An increased pharyngeal reflex caused dysphagia in this patient. An EEG revealed intermittent high amplitude slow wave activity. However, head MRI, blood count, serum chemistry, and cerebrospinal fluid examination showed no abnormality. Initially, brainstem encephalitis with unknown etiology was diagnosed. The hiccups, diplopia, and ptosis were improved by corticosteroid therapy, but other symptoms were refractory to corticosteroid therapy and IVIg. After these immunotherapies, anti-Borrelia IgG and IgM antibodies were found to be positive, and symptoms, including dysphagia, were improved by doxycycline and cefotaxime. Because the clinical symptoms of Borrelia infection are widely variable, neuroborreliosis should be considered in patients with brainstem encephalitis refractory to conventional immunotherapies.

Original languageEnglish
Pages (from-to)265-267
Number of pages3
JournalClinical Neurology
Volume50
Issue number4
DOIs
Publication statusPublished - Jan 1 2010

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Borrelia
Encephalitis
Deglutition Disorders
Brain Stem
Diplopia
Hiccup
Immunotherapy
Adrenal Cortex Hormones
Gagging
Borrelia Infections
Pathologic Nystagmus
Mobility Limitation
Dysarthria
Cefotaxime
Doxycycline
Muscle Weakness
Neurologic Examination
Ataxia
Consciousness
Cerebrospinal Fluid

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

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A case of Borrelia brainstem encephalitis presenting with severe dysphagia. / Kawano, Yuji; Shigeto, Hiroshi; Shiraishi, Yoshimasa; Ohyagi, Yasumasa; Kira, Jun-Ichi.

In: Clinical Neurology, Vol. 50, No. 4, 01.01.2010, p. 265-267.

Research output: Contribution to journalArticle

Kawano, Yuji ; Shigeto, Hiroshi ; Shiraishi, Yoshimasa ; Ohyagi, Yasumasa ; Kira, Jun-Ichi. / A case of Borrelia brainstem encephalitis presenting with severe dysphagia. In: Clinical Neurology. 2010 ; Vol. 50, No. 4. pp. 265-267.
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