A 56-year-old man with a history of pervasive developmental disorder complained of a scrotal mass for five years. The verrucous tumor not only covered the scrotum and the penile shaft but also extended to the prepuce close to the glans, with crusts. Histologically, the tumor cells consisted of atypical keratinocytes with cancer pearl formation and surface koilocyte formation, leading to the diagnosis of a Buschke-Löwenstein tumor. The nuclei of some of the tumor cells were immunoreactive to anti-human papilloma virus antibodies. Three courses of CA chemotherapy(combined therapy of cisplatin and doxorubicin) and 60 Gyof broad radiotherapysuccessfullycured the lesion. No recurrence was observed after 24 months.
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