A case of CD56+ cutaneous aleukaemic granulocytic sarcoma with myelodysplastic syndrome

Y. Murakami, S. Nagae, E. Matsuishi, K. Irie, Masutaka Furue

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17 Citations (Scopus)

Abstract

We describe a 70-year-old man with cutaneous granulocytic sarcoma who presented with numerous cutaneous nodules but without any leukaemic involvement of the peripheral blood. The tumour cells were positive for lysozyme, peroxidase, CD11a, CD11c, CD33 and HLA-DR, and weakly positive for CD4 and CD14, suggesting granulocytic differentiation. The bone marrow at admission showed dysplasia of the erythrocytic and granulocytic lineage and complex chromosomal abnormalities in association with an increase in monocytes. The patient was diagnosed as having granulocytic sarcoma of monocytic lineage with concomitant myelodysplastic syndrome. In this case, tumour cells also expressed the neural cell adhesion molecule (CD56), which has been suggested as a possible risk factor for developing granulocytic sarcoma in acute myelogenous leukaemia.

Original languageEnglish
Pages (from-to)587-590
Number of pages4
JournalBritish Journal of Dermatology
Volume143
Issue number3
DOIs
Publication statusPublished - Oct 16 2000

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Myeloid Sarcoma
Myelodysplastic Syndromes
Skin
Neural Cell Adhesion Molecules
HLA-DR Antigens
Muramidase
Acute Myeloid Leukemia
Chromosome Aberrations
Peroxidase
Monocytes
Neoplasms
Bone Marrow

All Science Journal Classification (ASJC) codes

  • Dermatology

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A case of CD56+ cutaneous aleukaemic granulocytic sarcoma with myelodysplastic syndrome. / Murakami, Y.; Nagae, S.; Matsuishi, E.; Irie, K.; Furue, Masutaka.

In: British Journal of Dermatology, Vol. 143, No. 3, 16.10.2000, p. 587-590.

Research output: Contribution to journalArticle

Murakami, Y. ; Nagae, S. ; Matsuishi, E. ; Irie, K. ; Furue, Masutaka. / A case of CD56+ cutaneous aleukaemic granulocytic sarcoma with myelodysplastic syndrome. In: British Journal of Dermatology. 2000 ; Vol. 143, No. 3. pp. 587-590.
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