Abstract
We describe a 70-year-old man with cutaneous granulocytic sarcoma who presented with numerous cutaneous nodules but without any leukaemic involvement of the peripheral blood. The tumour cells were positive for lysozyme, peroxidase, CD11a, CD11c, CD33 and HLA-DR, and weakly positive for CD4 and CD14, suggesting granulocytic differentiation. The bone marrow at admission showed dysplasia of the erythrocytic and granulocytic lineage and complex chromosomal abnormalities in association with an increase in monocytes. The patient was diagnosed as having granulocytic sarcoma of monocytic lineage with concomitant myelodysplastic syndrome. In this case, tumour cells also expressed the neural cell adhesion molecule (CD56), which has been suggested as a possible risk factor for developing granulocytic sarcoma in acute myelogenous leukaemia.
| Original language | English |
|---|---|
| Pages (from-to) | 587-590 |
| Number of pages | 4 |
| Journal | British Journal of Dermatology |
| Volume | 143 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Oct 16 2000 |
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All Science Journal Classification (ASJC) codes
- Dermatology
Cite this
A case of CD56+ cutaneous aleukaemic granulocytic sarcoma with myelodysplastic syndrome. / Murakami, Y.; Nagae, S.; Matsuishi, E.; Irie, K.; Furue, Masutaka.
In: British Journal of Dermatology, Vol. 143, No. 3, 16.10.2000, p. 587-590.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A case of CD56+ cutaneous aleukaemic granulocytic sarcoma with myelodysplastic syndrome
AU - Murakami, Y.
AU - Nagae, S.
AU - Matsuishi, E.
AU - Irie, K.
AU - Furue, Masutaka
PY - 2000/10/16
Y1 - 2000/10/16
N2 - We describe a 70-year-old man with cutaneous granulocytic sarcoma who presented with numerous cutaneous nodules but without any leukaemic involvement of the peripheral blood. The tumour cells were positive for lysozyme, peroxidase, CD11a, CD11c, CD33 and HLA-DR, and weakly positive for CD4 and CD14, suggesting granulocytic differentiation. The bone marrow at admission showed dysplasia of the erythrocytic and granulocytic lineage and complex chromosomal abnormalities in association with an increase in monocytes. The patient was diagnosed as having granulocytic sarcoma of monocytic lineage with concomitant myelodysplastic syndrome. In this case, tumour cells also expressed the neural cell adhesion molecule (CD56), which has been suggested as a possible risk factor for developing granulocytic sarcoma in acute myelogenous leukaemia.
AB - We describe a 70-year-old man with cutaneous granulocytic sarcoma who presented with numerous cutaneous nodules but without any leukaemic involvement of the peripheral blood. The tumour cells were positive for lysozyme, peroxidase, CD11a, CD11c, CD33 and HLA-DR, and weakly positive for CD4 and CD14, suggesting granulocytic differentiation. The bone marrow at admission showed dysplasia of the erythrocytic and granulocytic lineage and complex chromosomal abnormalities in association with an increase in monocytes. The patient was diagnosed as having granulocytic sarcoma of monocytic lineage with concomitant myelodysplastic syndrome. In this case, tumour cells also expressed the neural cell adhesion molecule (CD56), which has been suggested as a possible risk factor for developing granulocytic sarcoma in acute myelogenous leukaemia.
UR - http://www.scopus.com/inward/record.url?scp=0033800892&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033800892&partnerID=8YFLogxK
U2 - 10.1046/j.1365-2133.2000.03714.x
DO - 10.1046/j.1365-2133.2000.03714.x
M3 - Article
C2 - 10971333
AN - SCOPUS:0033800892
VL - 143
SP - 587
EP - 590
JO - British Journal of Dermatology
JF - British Journal of Dermatology
SN - 0007-0963
IS - 3
ER -