A case of combined hepatocellular and cholangiocarcinoma showing tumor growth and invasion to the diaphragm during interferon-alpha and 5-fluorouracil combined intra-arterial chemotherapy

Takehiro Noda, Hiroaki Nagano, Shigeru Marubashi, Shogo Kobayashi, Yutaka Takeda, Masahiro Murakami, Yoshito Tomimaru, Keizo Dono, Koji Umeshita, Mika Nakayama, Toshihide Shima, Kenichi Wakasa, Morito Monden, Yuichiro Doki, Masaki Mori

Research output: Contribution to journalArticlepeer-review

Abstract

We report a case of combined hepatocellular and cholangiocarcinoma showing tumor growth and invasion to the diaphragm during interferon-alpha (IFN-alpha) and 5-fluorouracil (5-FU) combined intra-arterial chemotherapy. A 63-year-old female was in hospital for treatment of hepatic tumor in left lobe with portal venous tumor thrombus. She was treated by IFN-alpha/5-FU chemotherapy, and the tumor was significantly reduced. For 28 months, the tumor was successfully treated by IFN-alpha/5-FU chemotherapy. But, thereafter the abdominal computed tomography showed the tumor re-growth and invasion to the diaphragm. Then the patient underwent the tumor resection. The histological findings were consistent with combined hepatocellular and cholangiocarcinoma. Immunohistological examination revealed a heterogeneous expression of IFN-alpha receptor 2. This case suggested that the growth of cancer cells without sensitivity to IFN-alpha/5-FU chemotherapy and the blood supply via the diaphragm led the relapse of IFN-alpha/5-FU chemotherapy.

Original languageEnglish
Pages (from-to)2099-2102
Number of pages4
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume35
Issue number12
Publication statusPublished - Nov 2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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