A case of cortisol producing adrenal adenoma associated with a latent aldosteronoma: Usefulness of the ACTH loading test for the detection of covert aldosteronism in overt Cushing syndrome

Daisuke Kukidome, Nobuhiro Miyamura, Kourin Sakakida, Seiya Shimoda, Yoshinori Shigematu, Kazuhiko Nishi, Yasuyuki Yamashita, Masatoshi Eto, Hironobu Sasano, Eiichi Araki

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A 36-year-old woman with Cushing syndrome was evaluated for coexisting hyperaldosteronism, which was suggested by an abnormal response of the aldosterone-to-cortisol ratio in peripheral blood to the ACTHadministration despite a low basal aldosterone-to-renin ratio. Computed tomography revealed two independent tumors in the left adrenal gland, and adrenal venous sampling indicated hyperaldosteronism in addition to hypercortisolism in the same side. Postsurgical study including immunohistochemical analysis of steroidogenic enzymes suggested one adenoma to be cortisol-producing and the other, aldosterone-producing. The comorbidity of these different hormone-producing adenomas is not rare and careful pre-surgical evaluation is necessary to avoid post-surgical exacerbation of latent hyperaldosteronism.

Original languageEnglish
Pages (from-to)395-400
Number of pages6
JournalInternal Medicine
Volume51
Issue number4
DOIs
Publication statusPublished - 2012

All Science Journal Classification (ASJC) codes

  • Internal Medicine

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