A case of cutaneous nodular adult T-cell leukemia/lymphoma treated with biweekly CHOP chemotherapy and local electron beam irradation

Y. Murakami, S. Nagae, Masutaka Furue

Research output: Contribution to journalArticle

Abstract

A 69-year-old Japanese woman presented multiple cutaneous nudules on her left upper arm, left thigh and left ankle, but demonstrated no palpable surface lymphadenopathy. We could not detect any extra-cutaneous lesions based on the findings of abdominal echography, chest and abdominal computed tomography and Ga-scintigraphy. The leukocyte count in the peripheral blood was 4800/mm3 with 3% circulating atypical lymphoid cells. Anti-HTLV-1 antibody was positive in her sera. Histologically, the nodule was diagnosed to be malignant lymphoma, diffuse pleomorphic type. A southern blot analysis showed the monoclonal integration of HTLV-1 proviral DNA into the atypical cells of a cutaneous nodule. Based on these clinical and laboratory findings, the patient was diagnosed to have adult T-cell leukemia/lymphoma, cutaneous nodular type. She was treated with one cycle of CHOP and 5 cycles of THP-COP chemotherapy associated with 30 Gy of local electron beam irradiation.

Original languageEnglish
Pages (from-to)172-176
Number of pages5
JournalNishinihon Journal of Dermatology
Volume61
Issue number2
DOIs
Publication statusPublished - Jan 1 1999

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Adult T Cell Leukemia Lymphoma
Electrons
Drug Therapy
Skin
Human T-lymphotropic virus 1
Deltaretrovirus Antibodies
Southern Blotting
Thigh
Leukocyte Count
Ankle
Radionuclide Imaging
Ultrasonography
Lymphoma
Arm
Thorax
Tomography
Lymphocytes
DNA
Serum

All Science Journal Classification (ASJC) codes

  • Dermatology

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A case of cutaneous nodular adult T-cell leukemia/lymphoma treated with biweekly CHOP chemotherapy and local electron beam irradation. / Murakami, Y.; Nagae, S.; Furue, Masutaka.

In: Nishinihon Journal of Dermatology, Vol. 61, No. 2, 01.01.1999, p. 172-176.

Research output: Contribution to journalArticle

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