A case of diffuse-type primary hepatic lymphoma mimicking diffuse hepatocellular carcinoma

Koichiro Kaneko, Akihiro Nishie, Fumitou Arima, Tsuyoshi Yoshida, Ken Ono, Junichi Omagari, Hiroshi Honda

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25 Citations (Scopus)


Primary hepatic lymphoma (PHL) is a very rare disease, especially in the diffuse type. We report a case of a middle-aged man with hepatitis C virus infection who developed diffuse-type PHL mimicking diffuse hepatocellular carcinoma (HCC). Contrast-enhanced computed tomography (CT) and magnetic resonance imaging showed diffusely infiltrated hypovascular lesions throughout the liver but no intrahepatic portal venous thrombus was observed. Diffusion-weighted imaging and 18F-FDG positron emission tomography/CT respectively showed a very low apparent diffusion coefficient value and high FDG uptake. These findings were more suggestive of diffusetype PHL than diffuse HCC. Liver biopsy examination confirmed a diagnosis of diffuse large B-cell lymphoma. Systemic staging revealed no evidence of nodal or bone marrow involvement so PHL was diagnosed. The patient was treated with chemotherapy and achieved complete remission. We suggest that a combination of image modalities may enable differentiation of diffuse-type PHL from diffuse HCC.

Original languageEnglish
Pages (from-to)303-307
Number of pages5
JournalAnnals of Nuclear Medicine
Issue number4
Publication statusPublished - May 2011

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging


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