A case of diffuse-type primary hepatic lymphoma mimicking diffuse hepatocellular carcinoma

Koichiro Kaneko, Akihiro Nishie, Fumitou Arima, Tsuyoshi Yoshida, Ken Ono, Junichi Omagari, Hiroshi Honda

Research output: Contribution to journalArticle

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Abstract

Primary hepatic lymphoma (PHL) is a very rare disease, especially in the diffuse type. We report a case of a middle-aged man with hepatitis C virus infection who developed diffuse-type PHL mimicking diffuse hepatocellular carcinoma (HCC). Contrast-enhanced computed tomography (CT) and magnetic resonance imaging showed diffusely infiltrated hypovascular lesions throughout the liver but no intrahepatic portal venous thrombus was observed. Diffusion-weighted imaging and 18F-FDG positron emission tomography/CT respectively showed a very low apparent diffusion coefficient value and high FDG uptake. These findings were more suggestive of diffusetype PHL than diffuse HCC. Liver biopsy examination confirmed a diagnosis of diffuse large B-cell lymphoma. Systemic staging revealed no evidence of nodal or bone marrow involvement so PHL was diagnosed. The patient was treated with chemotherapy and achieved complete remission. We suggest that a combination of image modalities may enable differentiation of diffuse-type PHL from diffuse HCC.

Original languageEnglish
Pages (from-to)303-307
Number of pages5
JournalAnnals of Nuclear Medicine
Volume25
Issue number4
DOIs
Publication statusPublished - May 1 2011

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Non-Hodgkin's Lymphoma
Hepatocellular Carcinoma
Liver
Lymphoma
Lymphoma, Large B-Cell, Diffuse
Fluorodeoxyglucose F18
Virus Diseases
Rare Diseases
Hepacivirus
Thrombosis
Bone Marrow
Tomography
Magnetic Resonance Imaging
Biopsy
Drug Therapy

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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A case of diffuse-type primary hepatic lymphoma mimicking diffuse hepatocellular carcinoma. / Kaneko, Koichiro; Nishie, Akihiro; Arima, Fumitou; Yoshida, Tsuyoshi; Ono, Ken; Omagari, Junichi; Honda, Hiroshi.

In: Annals of Nuclear Medicine, Vol. 25, No. 4, 01.05.2011, p. 303-307.

Research output: Contribution to journalArticle

Kaneko, Koichiro ; Nishie, Akihiro ; Arima, Fumitou ; Yoshida, Tsuyoshi ; Ono, Ken ; Omagari, Junichi ; Honda, Hiroshi. / A case of diffuse-type primary hepatic lymphoma mimicking diffuse hepatocellular carcinoma. In: Annals of Nuclear Medicine. 2011 ; Vol. 25, No. 4. pp. 303-307.
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AU - Honda, Hiroshi

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