A case of epithelioid sarcoma

Makiko Nakahara, Shuhei Imayama, Miki Uryu, Reiko Kawasaki, Morishige Takeshita, Setsuko Ueda, Masutaka Furue

Research output: Contribution to journalArticle

Abstract

We studied a case of epithelioid sarcoma that had developed on the right sole of a 27-year-old Japanese man. The lesion, which had a history of 6 months, presented as indurated erythematous plaque of 4 × 7 cm scattered with several irregular scars. Microscopically, the majority of the proliferated tumor cells were large, plump epithelioid-like cells with eosinophilic cytoplasm and an oval nucleus. The remainder were fibroblast-like, bearing spindle-shaped cell bodies. Immunohistochemistry indicated that the epithelioid-like cells were positive for Vimentin and AE1/AE3, but that the fibroblast-like cells were negative. Electron microscopy revealed that the former cells were characterized by an abundant and monotonous cytoplasm being filled with intermediate filaments densely arranged throughout the cell bodies. Small mitochondria were the only organelles around the nucleus. On the other hand, the fibroblast-like cells were characterized by prominent cytoplasmic organelles, including mitochondria, rough endoplasmic reticulum, Golgi apparatus and free ribosomes, and by abundant glycogen within the cytoplasm. Regardless of such different features, both cells were partially surrounded by basal lamina and exhibited close contact with juxta cells with gap junctions. These findings support the belief that the tumor was related etiologically to synovial sarcoma.

Original languageEnglish
Pages (from-to)585-589
Number of pages5
JournalNishinihon Journal of Dermatology
Volume66
Issue number6
DOIs
Publication statusPublished - Dec 1 2004

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Sarcoma
Epithelioid Cells
Cytoplasm
Fibroblasts
Organelles
Mitochondria
Synovial Sarcoma
Intermediate Filaments
Rough Endoplasmic Reticulum
Gap Junctions
Golgi Apparatus
Vimentin
Glycogen
Ribosomes
Basement Membrane
Cicatrix
Neoplasms
Electron Microscopy
Immunohistochemistry
Cell Body

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Nakahara, M., Imayama, S., Uryu, M., Kawasaki, R., Takeshita, M., Ueda, S., & Furue, M. (2004). A case of epithelioid sarcoma. Nishinihon Journal of Dermatology, 66(6), 585-589. https://doi.org/10.2336/nishinihonhifu.66.585

A case of epithelioid sarcoma. / Nakahara, Makiko; Imayama, Shuhei; Uryu, Miki; Kawasaki, Reiko; Takeshita, Morishige; Ueda, Setsuko; Furue, Masutaka.

In: Nishinihon Journal of Dermatology, Vol. 66, No. 6, 01.12.2004, p. 585-589.

Research output: Contribution to journalArticle

Nakahara, M, Imayama, S, Uryu, M, Kawasaki, R, Takeshita, M, Ueda, S & Furue, M 2004, 'A case of epithelioid sarcoma', Nishinihon Journal of Dermatology, vol. 66, no. 6, pp. 585-589. https://doi.org/10.2336/nishinihonhifu.66.585
Nakahara M, Imayama S, Uryu M, Kawasaki R, Takeshita M, Ueda S et al. A case of epithelioid sarcoma. Nishinihon Journal of Dermatology. 2004 Dec 1;66(6):585-589. https://doi.org/10.2336/nishinihonhifu.66.585
Nakahara, Makiko ; Imayama, Shuhei ; Uryu, Miki ; Kawasaki, Reiko ; Takeshita, Morishige ; Ueda, Setsuko ; Furue, Masutaka. / A case of epithelioid sarcoma. In: Nishinihon Journal of Dermatology. 2004 ; Vol. 66, No. 6. pp. 585-589.
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