A case of erythrodermic bullous pemphigoid

A 73-year-old man visited our clinic with complaints of erythroderma and multiple erosion on his entire body. Physical examination and histopathology of the skin lesions suggested a diagnosis of erythroderma caused by chronic eczema or drug eruption. Numerous eosinophils were observed in the upper dermis ; therefore, we checked the serum anti-BP180 antibody level and found it to be elevated. Direct immunofluorescence staining revealed linear depositions of IgG and C3 along the basement membrane zone. A final diagnosis of erythrodermic bullous pemphigoid was made on the basis of these findings. Oral prednisolone (0.5 mg/kg/day) successfully controlled the erythrodermic condition.