A case of extramammary Paget's disease after excision of bilateral breast carcinoma

Satoko Kumazawa, Kou Dan, Teiichi Masuda, Kazunori Urabe, Masutaka Furue

Research output: Contribution to journalArticlepeer-review

Abstract

We report a 58-year old female with itchy perianal erythema that developed gradually over a 5-year period and was histologically diagnosed as extramammary Paget's disease (EMPD). Right breast carcinoma had been excised 10 years previously and left breast carcinoma 4 years previously. Recently, it has been suggested that androgen receptor expression and overexpression of erbB-2 onco-protein may play a part in the progression of EMPD. On the other hand, estrogen, estrogen receptor expression and overexpression of erbB-2 onco-protein have also been associated with the onset and progression of breast carcinoma. Immunohistochemically, estrogen receptor expression and overexpression of erbB-2 onco-protein were observed in this patient's bilateral breast carcinoma and EMPD samples.

Original languageEnglish
Pages (from-to)273-276
Number of pages4
JournalNishinihon Journal of Dermatology
Volume69
Issue number3
DOIs
Publication statusPublished - 2007

All Science Journal Classification (ASJC) codes

  • Dermatology

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