A case of extramammary Paget's disease after excision of bilateral breast carcinoma

We report a 58-year old female with itchy perianal erythema that developed gradually over a 5-year period and was histologically diagnosed as extramammary Paget's disease (EMPD). Right breast carcinoma had been excised 10 years previously and left breast carcinoma 4 years previously. Recently, it has been suggested that androgen receptor expression and overexpression of erbB-2 onco-protein may play a part in the progression of EMPD. On the other hand, estrogen, estrogen receptor expression and overexpression of erbB-2 onco-protein have also been associated with the onset and progression of breast carcinoma. Immunohistochemically, estrogen receptor expression and overexpression of erbB-2 onco-protein were observed in this patient's bilateral breast carcinoma and EMPD samples.