A case of gastrointestinal stromal tumor of the jejunum successfully treated by preoperative induction chemotherapy with imatinib mesylate administered through jejunostomy and subsequent surgical resection

Hideyo Kimura, Takao Ohtsuka, Hiroki Toma, Junji Ueda, Yusuke Mizuuchi, Hidetaka Yamamoto, Shunichi Takahata, Yoshinao Oda, Takashi Ueki, Masao Tanaka

Research output: Contribution to journalArticle

Abstract

A 70-year-old female patient with a palpable mass in the left upper abdomen suffered from abdominal pain and fever. Abdominal computed tomography showed a jejunal tumor 11 cm in diameter with ascites, suggesting rupture of the tumor. Histological diagnosis via endoscopic ultrasound-guided fine needle aspiration indicated c-kit-positive gastrointestinal stromal tumor. Diagnostic laparoscopy demonstrated a large jejunal tumor possibly invading the stomach and pancreas. The patient then underwent tube jejunostomy. Thereafter, preoperative induction chemotherapy with imatinib mesylate (400 mg/body/day) via jejunostomy was administered for 6 months, resulting in 20% reduction of the tumor diameter and disappearance of any indication of stomach and pancreas invasion. The patient then underwent radical partial resection of the jejunum without combined resection of either the stomach or pancreas. Postoperative adjuvant chemotherapy with imatinib mesylate (400 mg/body/day) was also indicated. No sign of recurrence has been detected to date after 1 year of follow-up.

Original languageEnglish
Pages (from-to)391-394
Number of pages4
JournalJapanese Journal of Cancer and Chemotherapy
Volume41
Issue number3
Publication statusPublished - Mar 2014

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Jejunostomy
Induction Chemotherapy
Gastrointestinal Stromal Tumors
Jejunum
Pancreas
Stomach
Neoplasms
Endoscopic Ultrasound-Guided Fine Needle Aspiration
Adjuvant Chemotherapy
Ascites
Abdomen
Laparoscopy
Abdominal Pain
Rupture
Fever
Tomography
Recurrence
Imatinib Mesylate

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

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title = "A case of gastrointestinal stromal tumor of the jejunum successfully treated by preoperative induction chemotherapy with imatinib mesylate administered through jejunostomy and subsequent surgical resection",
abstract = "A 70-year-old female patient with a palpable mass in the left upper abdomen suffered from abdominal pain and fever. Abdominal computed tomography showed a jejunal tumor 11 cm in diameter with ascites, suggesting rupture of the tumor. Histological diagnosis via endoscopic ultrasound-guided fine needle aspiration indicated c-kit-positive gastrointestinal stromal tumor. Diagnostic laparoscopy demonstrated a large jejunal tumor possibly invading the stomach and pancreas. The patient then underwent tube jejunostomy. Thereafter, preoperative induction chemotherapy with imatinib mesylate (400 mg/body/day) via jejunostomy was administered for 6 months, resulting in 20{\%} reduction of the tumor diameter and disappearance of any indication of stomach and pancreas invasion. The patient then underwent radical partial resection of the jejunum without combined resection of either the stomach or pancreas. Postoperative adjuvant chemotherapy with imatinib mesylate (400 mg/body/day) was also indicated. No sign of recurrence has been detected to date after 1 year of follow-up.",
author = "Hideyo Kimura and Takao Ohtsuka and Hiroki Toma and Junji Ueda and Yusuke Mizuuchi and Hidetaka Yamamoto and Shunichi Takahata and Yoshinao Oda and Takashi Ueki and Masao Tanaka",
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T1 - A case of gastrointestinal stromal tumor of the jejunum successfully treated by preoperative induction chemotherapy with imatinib mesylate administered through jejunostomy and subsequent surgical resection

AU - Kimura, Hideyo

AU - Ohtsuka, Takao

AU - Toma, Hiroki

AU - Ueda, Junji

AU - Mizuuchi, Yusuke

AU - Yamamoto, Hidetaka

AU - Takahata, Shunichi

AU - Oda, Yoshinao

AU - Ueki, Takashi

AU - Tanaka, Masao

PY - 2014/3

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N2 - A 70-year-old female patient with a palpable mass in the left upper abdomen suffered from abdominal pain and fever. Abdominal computed tomography showed a jejunal tumor 11 cm in diameter with ascites, suggesting rupture of the tumor. Histological diagnosis via endoscopic ultrasound-guided fine needle aspiration indicated c-kit-positive gastrointestinal stromal tumor. Diagnostic laparoscopy demonstrated a large jejunal tumor possibly invading the stomach and pancreas. The patient then underwent tube jejunostomy. Thereafter, preoperative induction chemotherapy with imatinib mesylate (400 mg/body/day) via jejunostomy was administered for 6 months, resulting in 20% reduction of the tumor diameter and disappearance of any indication of stomach and pancreas invasion. The patient then underwent radical partial resection of the jejunum without combined resection of either the stomach or pancreas. Postoperative adjuvant chemotherapy with imatinib mesylate (400 mg/body/day) was also indicated. No sign of recurrence has been detected to date after 1 year of follow-up.

AB - A 70-year-old female patient with a palpable mass in the left upper abdomen suffered from abdominal pain and fever. Abdominal computed tomography showed a jejunal tumor 11 cm in diameter with ascites, suggesting rupture of the tumor. Histological diagnosis via endoscopic ultrasound-guided fine needle aspiration indicated c-kit-positive gastrointestinal stromal tumor. Diagnostic laparoscopy demonstrated a large jejunal tumor possibly invading the stomach and pancreas. The patient then underwent tube jejunostomy. Thereafter, preoperative induction chemotherapy with imatinib mesylate (400 mg/body/day) via jejunostomy was administered for 6 months, resulting in 20% reduction of the tumor diameter and disappearance of any indication of stomach and pancreas invasion. The patient then underwent radical partial resection of the jejunum without combined resection of either the stomach or pancreas. Postoperative adjuvant chemotherapy with imatinib mesylate (400 mg/body/day) was also indicated. No sign of recurrence has been detected to date after 1 year of follow-up.

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