A case of Gitelman's syndrome with decreased angiotensin II - Forming activity

Kimika Eto, Uran Onaka, Takuya Tsuchihashi, Takashi Hirano, Masaru Nakayama, Kosuke Masutani, Hideki Hirakata, Hidenori Urata, Minoru Yasujima

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Gitelman's syndrome (GS) is a variant of Bartter's syndrome (BS) characterized by hypokalemic alkalosis, hypomagnesemia, hypocalciuria and secondary aldosteronism without hypertension. A 31-year old Japanese man who had suffered from mild hypokalemia for 10 years was admitted to our hospital. He had metabolic alkalosis, hypokalemia and hypocalciuria. Since he had two missense mutations (R261C and L623P) in the thiazide-sensitive Na-CI cotransporter (TSC) gene (SLC12A3), he was diagnosed as having GS. He showed hyperreninism and a high angiotensin I (Ang I) level, whereas his angiotensin II (Ang II) and aldosterone levels were not elevated. His angiotensin converting enzyme (ACE) activities were normal, and administration of captopril inhibited the production of Ang II and aldosterone. We evaluated the Ang II-forming activity (AIIFA) of other enzymes in his lymphocytes. Interestingly, chymase-dependent AIIFA was not detected in the lymphocytes. Together, these results suggest that the lack of chymase activity resulted in the manifestation of GS without hyperaldosteronism.

Original languageEnglish
Pages (from-to)545-549
Number of pages5
JournalHypertension Research
Volume29
Issue number7
DOIs
Publication statusPublished - Jul 1 2006

Fingerprint

Gitelman Syndrome
Angiotensin II
Chymases
Alkalosis
Hyperaldosteronism
Hypokalemia
Aldosterone
Bartter Syndrome
Lymphocytes
Thiazides
Angiotensin I
Captopril
Peptidyl-Dipeptidase A
Missense Mutation
Hypertension
Enzymes
Genes

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Eto, K., Onaka, U., Tsuchihashi, T., Hirano, T., Nakayama, M., Masutani, K., ... Yasujima, M. (2006). A case of Gitelman's syndrome with decreased angiotensin II - Forming activity. Hypertension Research, 29(7), 545-549. https://doi.org/10.1291/hypres.29.545

A case of Gitelman's syndrome with decreased angiotensin II - Forming activity. / Eto, Kimika; Onaka, Uran; Tsuchihashi, Takuya; Hirano, Takashi; Nakayama, Masaru; Masutani, Kosuke; Hirakata, Hideki; Urata, Hidenori; Yasujima, Minoru.

In: Hypertension Research, Vol. 29, No. 7, 01.07.2006, p. 545-549.

Research output: Contribution to journalArticle

Eto, K, Onaka, U, Tsuchihashi, T, Hirano, T, Nakayama, M, Masutani, K, Hirakata, H, Urata, H & Yasujima, M 2006, 'A case of Gitelman's syndrome with decreased angiotensin II - Forming activity', Hypertension Research, vol. 29, no. 7, pp. 545-549. https://doi.org/10.1291/hypres.29.545
Eto K, Onaka U, Tsuchihashi T, Hirano T, Nakayama M, Masutani K et al. A case of Gitelman's syndrome with decreased angiotensin II - Forming activity. Hypertension Research. 2006 Jul 1;29(7):545-549. https://doi.org/10.1291/hypres.29.545
Eto, Kimika ; Onaka, Uran ; Tsuchihashi, Takuya ; Hirano, Takashi ; Nakayama, Masaru ; Masutani, Kosuke ; Hirakata, Hideki ; Urata, Hidenori ; Yasujima, Minoru. / A case of Gitelman's syndrome with decreased angiotensin II - Forming activity. In: Hypertension Research. 2006 ; Vol. 29, No. 7. pp. 545-549.
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