A case of gliomatosis cerebri

Remarkable improvement after radiation therapy

Nobuhiro Hata, T. Katsuts, T. Inoue, S. Uehara, M. Takeshita

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A 30-year-old female case of gliomatosis cerebri, which showed remarkable improvement after radiation therapy is reported. The lesion had spread widely in the frontal and parietal lobes of both sides, causing diffuse swelling of the cerebral hemispheres. A specimen obtained by open biopsy revealed diffuse proliferation of astrocytic (GFAP positive) tumor cells, associated with little tissue destruction. After whole-brain radiation of 60 Gy, the lesion shrunk gradually but markedly. Hemiparesis and mild dementia, which the patient had experienced before treatment, subsided completely within 6 months, until she was able to restart her job as a dentist. Although gliomatosis cerebri is thought to have a poor prognosis, this case demonstrates the potential of radiotherapy for this disease. Factors which may lead to a better outcome are discussed.

Original languageEnglish
Pages (from-to)409-414
Number of pages6
JournalNeurological Surgery
Volume29
Issue number5
Publication statusPublished - Jun 21 2001
Externally publishedYes

Fingerprint

Neuroepithelial Neoplasms
Radiotherapy
Radiation Dosage
Parietal Lobe
Cerebrum
Frontal Lobe
Paresis
Dentists
Dementia
Biopsy
Brain
Neoplasms
Therapeutics

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

Cite this

Hata, N., Katsuts, T., Inoue, T., Uehara, S., & Takeshita, M. (2001). A case of gliomatosis cerebri: Remarkable improvement after radiation therapy. Neurological Surgery, 29(5), 409-414.

A case of gliomatosis cerebri : Remarkable improvement after radiation therapy. / Hata, Nobuhiro; Katsuts, T.; Inoue, T.; Uehara, S.; Takeshita, M.

In: Neurological Surgery, Vol. 29, No. 5, 21.06.2001, p. 409-414.

Research output: Contribution to journalArticle

Hata, N, Katsuts, T, Inoue, T, Uehara, S & Takeshita, M 2001, 'A case of gliomatosis cerebri: Remarkable improvement after radiation therapy', Neurological Surgery, vol. 29, no. 5, pp. 409-414.
Hata N, Katsuts T, Inoue T, Uehara S, Takeshita M. A case of gliomatosis cerebri: Remarkable improvement after radiation therapy. Neurological Surgery. 2001 Jun 21;29(5):409-414.
Hata, Nobuhiro ; Katsuts, T. ; Inoue, T. ; Uehara, S. ; Takeshita, M. / A case of gliomatosis cerebri : Remarkable improvement after radiation therapy. In: Neurological Surgery. 2001 ; Vol. 29, No. 5. pp. 409-414.
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