A case of glucagonoma with skin lesions, anemia, and hypoaminoacidemia markedly improved by medical therapy

Toshiaki Ohkuma, Masanori Iwase, Yasuhiro Idewaki, Yohei Kikuchi, Hiroki Fujii, Miwako Oku, Shoko Morimoto, Yasufumi Doi, Udai Nakamura, Mitsuo Iida

Research output: Contribution to journalArticle

Abstract

We report a rare case of glucagonoma in the elderly ameliorated by medical therapy, including anabolic steroid. A 74-year-old woman seen for necrolytic migratory erythema and diagnosed with glucagonoma due to hyperglucagonemia (13,000 pg/m/) and a pancreas-body tumor 3 cm in diameter also had multiple micrometastases to the liver, deep venous thrombosis, and pulmonary embolism. Her poor general condition of 16.9 kg/m2 BMI, 1.5 g/d/serum albumin, and 6.8 g/d/hemoglobin was improved by treatment with octreotide, which decreased plasma glucagon to 1,500 pg/m/and amino acid supplementation, which markedly improved necrolytic migratory erythema. To sufficiently improve hypoalbuminemia and anemia, we administered the anabolic steroid metenolone, which ameliorated hypoaminoacidemia, hypoalbuminemia, and anemia, with serum albumin rising to 2.3 g/d/and Hb to 8.5 g/d/. Insulin therapy was required to manage hyperglycemia associated with reduced endogenous insulin secretion.

Original languageEnglish
Pages (from-to)949-955
Number of pages7
JournalJournal of the Japan Diabetes Society
Volume52
Issue number12
Publication statusPublished - Dec 1 2009

Fingerprint

Glucagonoma
Necrolytic Migratory Erythema
Testosterone Congeners
Anemia
Hypoalbuminemia
Serum Albumin
Skin
Methenolone
Insulin
Neoplasm Micrometastasis
Octreotide
Glucagon
Pulmonary Embolism
Venous Thrombosis
Hyperglycemia
Pancreas
Hemoglobins
Therapeutics
Amino Acids
Liver

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Ohkuma, T., Iwase, M., Idewaki, Y., Kikuchi, Y., Fujii, H., Oku, M., ... Iida, M. (2009). A case of glucagonoma with skin lesions, anemia, and hypoaminoacidemia markedly improved by medical therapy. Journal of the Japan Diabetes Society, 52(12), 949-955.

A case of glucagonoma with skin lesions, anemia, and hypoaminoacidemia markedly improved by medical therapy. / Ohkuma, Toshiaki; Iwase, Masanori; Idewaki, Yasuhiro; Kikuchi, Yohei; Fujii, Hiroki; Oku, Miwako; Morimoto, Shoko; Doi, Yasufumi; Nakamura, Udai; Iida, Mitsuo.

In: Journal of the Japan Diabetes Society, Vol. 52, No. 12, 01.12.2009, p. 949-955.

Research output: Contribution to journalArticle

Ohkuma, T, Iwase, M, Idewaki, Y, Kikuchi, Y, Fujii, H, Oku, M, Morimoto, S, Doi, Y, Nakamura, U & Iida, M 2009, 'A case of glucagonoma with skin lesions, anemia, and hypoaminoacidemia markedly improved by medical therapy', Journal of the Japan Diabetes Society, vol. 52, no. 12, pp. 949-955.
Ohkuma, Toshiaki ; Iwase, Masanori ; Idewaki, Yasuhiro ; Kikuchi, Yohei ; Fujii, Hiroki ; Oku, Miwako ; Morimoto, Shoko ; Doi, Yasufumi ; Nakamura, Udai ; Iida, Mitsuo. / A case of glucagonoma with skin lesions, anemia, and hypoaminoacidemia markedly improved by medical therapy. In: Journal of the Japan Diabetes Society. 2009 ; Vol. 52, No. 12. pp. 949-955.
@article{3382bf9520c64ac3ae735534ac3e0aad,
title = "A case of glucagonoma with skin lesions, anemia, and hypoaminoacidemia markedly improved by medical therapy",
abstract = "We report a rare case of glucagonoma in the elderly ameliorated by medical therapy, including anabolic steroid. A 74-year-old woman seen for necrolytic migratory erythema and diagnosed with glucagonoma due to hyperglucagonemia (13,000 pg/m/) and a pancreas-body tumor 3 cm in diameter also had multiple micrometastases to the liver, deep venous thrombosis, and pulmonary embolism. Her poor general condition of 16.9 kg/m2 BMI, 1.5 g/d/serum albumin, and 6.8 g/d/hemoglobin was improved by treatment with octreotide, which decreased plasma glucagon to 1,500 pg/m/and amino acid supplementation, which markedly improved necrolytic migratory erythema. To sufficiently improve hypoalbuminemia and anemia, we administered the anabolic steroid metenolone, which ameliorated hypoaminoacidemia, hypoalbuminemia, and anemia, with serum albumin rising to 2.3 g/d/and Hb to 8.5 g/d/. Insulin therapy was required to manage hyperglycemia associated with reduced endogenous insulin secretion.",
author = "Toshiaki Ohkuma and Masanori Iwase and Yasuhiro Idewaki and Yohei Kikuchi and Hiroki Fujii and Miwako Oku and Shoko Morimoto and Yasufumi Doi and Udai Nakamura and Mitsuo Iida",
year = "2009",
month = "12",
day = "1",
language = "English",
volume = "52",
pages = "949--955",
journal = "Journal of the Japan Diabetes Society",
issn = "0021-437X",
publisher = "Japan Diabetes Society",
number = "12",

}

TY - JOUR

T1 - A case of glucagonoma with skin lesions, anemia, and hypoaminoacidemia markedly improved by medical therapy

AU - Ohkuma, Toshiaki

AU - Iwase, Masanori

AU - Idewaki, Yasuhiro

AU - Kikuchi, Yohei

AU - Fujii, Hiroki

AU - Oku, Miwako

AU - Morimoto, Shoko

AU - Doi, Yasufumi

AU - Nakamura, Udai

AU - Iida, Mitsuo

PY - 2009/12/1

Y1 - 2009/12/1

N2 - We report a rare case of glucagonoma in the elderly ameliorated by medical therapy, including anabolic steroid. A 74-year-old woman seen for necrolytic migratory erythema and diagnosed with glucagonoma due to hyperglucagonemia (13,000 pg/m/) and a pancreas-body tumor 3 cm in diameter also had multiple micrometastases to the liver, deep venous thrombosis, and pulmonary embolism. Her poor general condition of 16.9 kg/m2 BMI, 1.5 g/d/serum albumin, and 6.8 g/d/hemoglobin was improved by treatment with octreotide, which decreased plasma glucagon to 1,500 pg/m/and amino acid supplementation, which markedly improved necrolytic migratory erythema. To sufficiently improve hypoalbuminemia and anemia, we administered the anabolic steroid metenolone, which ameliorated hypoaminoacidemia, hypoalbuminemia, and anemia, with serum albumin rising to 2.3 g/d/and Hb to 8.5 g/d/. Insulin therapy was required to manage hyperglycemia associated with reduced endogenous insulin secretion.

AB - We report a rare case of glucagonoma in the elderly ameliorated by medical therapy, including anabolic steroid. A 74-year-old woman seen for necrolytic migratory erythema and diagnosed with glucagonoma due to hyperglucagonemia (13,000 pg/m/) and a pancreas-body tumor 3 cm in diameter also had multiple micrometastases to the liver, deep venous thrombosis, and pulmonary embolism. Her poor general condition of 16.9 kg/m2 BMI, 1.5 g/d/serum albumin, and 6.8 g/d/hemoglobin was improved by treatment with octreotide, which decreased plasma glucagon to 1,500 pg/m/and amino acid supplementation, which markedly improved necrolytic migratory erythema. To sufficiently improve hypoalbuminemia and anemia, we administered the anabolic steroid metenolone, which ameliorated hypoaminoacidemia, hypoalbuminemia, and anemia, with serum albumin rising to 2.3 g/d/and Hb to 8.5 g/d/. Insulin therapy was required to manage hyperglycemia associated with reduced endogenous insulin secretion.

UR - http://www.scopus.com/inward/record.url?scp=76549127051&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=76549127051&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:76549127051

VL - 52

SP - 949

EP - 955

JO - Journal of the Japan Diabetes Society

JF - Journal of the Japan Diabetes Society

SN - 0021-437X

IS - 12

ER -