A case of glucagonoma with skin lesions, anemia, and hypoaminoacidemia markedly improved by medical therapy

Toshiaki Ohkuma, Masanori Iwase, Yasuhiro Idewaki, Yohei Kikuchi, Hiroki Fujii, Miwako Oku, Shoko Morimoto, Yasufumi Doi, Udai Nakamura, Mitsuo Iida

Research output: Contribution to journalArticle

Abstract

We report a rare case of glucagonoma in the elderly ameliorated by medical therapy, including anabolic steroid. A 74-year-old woman seen for necrolytic migratory erythema and diagnosed with glucagonoma due to hyperglucagonemia (13,000 pg/m/) and a pancreas-body tumor 3 cm in diameter also had multiple micrometastases to the liver, deep venous thrombosis, and pulmonary embolism. Her poor general condition of 16.9 kg/m2 BMI, 1.5 g/d/serum albumin, and 6.8 g/d/hemoglobin was improved by treatment with octreotide, which decreased plasma glucagon to 1,500 pg/m/and amino acid supplementation, which markedly improved necrolytic migratory erythema. To sufficiently improve hypoalbuminemia and anemia, we administered the anabolic steroid metenolone, which ameliorated hypoaminoacidemia, hypoalbuminemia, and anemia, with serum albumin rising to 2.3 g/d/and Hb to 8.5 g/d/. Insulin therapy was required to manage hyperglycemia associated with reduced endogenous insulin secretion.

Original languageEnglish
Pages (from-to)949-955
Number of pages7
JournalJournal of the Japan Diabetes Society
Volume52
Issue number12
Publication statusPublished - 2009

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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    Ohkuma, T., Iwase, M., Idewaki, Y., Kikuchi, Y., Fujii, H., Oku, M., Morimoto, S., Doi, Y., Nakamura, U., & Iida, M. (2009). A case of glucagonoma with skin lesions, anemia, and hypoaminoacidemia markedly improved by medical therapy. Journal of the Japan Diabetes Society, 52(12), 949-955.