A case of granulomatous blepharitis with intralymphatic histiocytosis

Miki Kohno, Akari Shigyo, Mito Toyoda, Masutaka Furue

Research output: Contribution to journalArticle

Abstract

A 54-year-old woman with a 6-month history of asymptomatic edematous erythema on her right eyelid visited our hospital. Rosacea had been present since the age of 47 years. Histological examination of the lesion revealed many granulomas and dilated vessels from the upper dermis to fat tissue. Within one of the dilated vessels, a massive aggregate composed of mononuclear cells was found. Immunohistochemical staining for CD68, a marker for histiocytes, showed intense staining of most cells in the intraluminal aggregate. Staining with D2-40, a marker for lymphatic endothelial cells, revealed that the vessels were lymphatic in nature. We diagnosed our patient as granulomatous blepharitis with intralymphatic histiocytosis based on the clinical and histopathological findings. The patient was treated with intralesional corticosteroids (triamcinolone acetonide) and oral tranilast administration (300 mg/day), and the swelling of her right eyelid was dramatically reduced. We concluded that this was a rare case in which a patient with granulomatous blepharitis also had intralymphatic histiocytosis.

Original languageEnglish
Pages (from-to)349-353
Number of pages5
JournalNishinihon Journal of Dermatology
Volume77
Issue number4
DOIs
Publication statusPublished - Jan 1 2015

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Blepharitis
Histiocytosis
Eyelids
Staining and Labeling
Rosacea
Triamcinolone Acetonide
Lymphatic Vessels
Histiocytes
Erythema
Dermis
Granuloma
Oral Administration
Adrenal Cortex Hormones
Endothelial Cells
Fats

All Science Journal Classification (ASJC) codes

  • Dermatology

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A case of granulomatous blepharitis with intralymphatic histiocytosis. / Kohno, Miki; Shigyo, Akari; Toyoda, Mito; Furue, Masutaka.

In: Nishinihon Journal of Dermatology, Vol. 77, No. 4, 01.01.2015, p. 349-353.

Research output: Contribution to journalArticle

Kohno, Miki ; Shigyo, Akari ; Toyoda, Mito ; Furue, Masutaka. / A case of granulomatous blepharitis with intralymphatic histiocytosis. In: Nishinihon Journal of Dermatology. 2015 ; Vol. 77, No. 4. pp. 349-353.
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