A case of hemoglobin variant (Hb J-Lome) complicated by abnormally low HbAlc at the onset of fulminant type 1 diabetes mellitus

Yasuhiro Ono, Kyosuke Yamamoto, Masao Ohashi, Taijiro Okabe, Koichiro Imamura, Toyoshi Inoguchi, Ryoichi Takayanagi, Ayako Miyazaki, Masafumi Koga

    Research output: Contribution to journalArticle

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    Abstract

    Fulminant type 1 diabetes mellitus (FT1DM), a new type 1 diabetes subtype, is characterized clinically by acute almost complete pancreatic β cell destruction. In contrast to markedly elevated plasma glucose, HbAlc is normal or only slightly elevated at FT1DM onset. We report the case of a 47-year-old man with FT1DM complicated by abnormally low hemoglobin. At diabetic ketoacidosis onset, glycated albumin (GA) was 25.3 %, HbAlc abnormally low at 3.6 %, and the GA/HbAlc ratio markedly high at 7.0. We identified a Lys → Asn mutation in 59 of the β-chain globin gene, yielding a diagnosis of Hb J-Lome. A complication of abnormal hemoglobin is thus to be suspected in cases of FT1DM with abnormally low HbAlc or a markedly high GA/HbAlc ratio.

    Original languageEnglish
    Pages (from-to)627-631
    Number of pages5
    JournalJournal of the Japan Diabetes Society
    Volume55
    Issue number8
    Publication statusPublished - Aug 1 2012

    Fingerprint

    Type 1 Diabetes Mellitus
    Hemoglobins
    Abnormal Hemoglobins
    Diabetic Ketoacidosis
    Globins
    hemoglobin J Lome
    Glucose
    Mutation
    Genes
    glycosylated serum albumin

    All Science Journal Classification (ASJC) codes

    • Internal Medicine
    • Endocrinology, Diabetes and Metabolism
    • Endocrinology

    Cite this

    Ono, Y., Yamamoto, K., Ohashi, M., Okabe, T., Imamura, K., Inoguchi, T., ... Koga, M. (2012). A case of hemoglobin variant (Hb J-Lome) complicated by abnormally low HbAlc at the onset of fulminant type 1 diabetes mellitus. Journal of the Japan Diabetes Society, 55(8), 627-631.

    A case of hemoglobin variant (Hb J-Lome) complicated by abnormally low HbAlc at the onset of fulminant type 1 diabetes mellitus. / Ono, Yasuhiro; Yamamoto, Kyosuke; Ohashi, Masao; Okabe, Taijiro; Imamura, Koichiro; Inoguchi, Toyoshi; Takayanagi, Ryoichi; Miyazaki, Ayako; Koga, Masafumi.

    In: Journal of the Japan Diabetes Society, Vol. 55, No. 8, 01.08.2012, p. 627-631.

    Research output: Contribution to journalArticle

    Ono, Y, Yamamoto, K, Ohashi, M, Okabe, T, Imamura, K, Inoguchi, T, Takayanagi, R, Miyazaki, A & Koga, M 2012, 'A case of hemoglobin variant (Hb J-Lome) complicated by abnormally low HbAlc at the onset of fulminant type 1 diabetes mellitus', Journal of the Japan Diabetes Society, vol. 55, no. 8, pp. 627-631.
    Ono, Yasuhiro ; Yamamoto, Kyosuke ; Ohashi, Masao ; Okabe, Taijiro ; Imamura, Koichiro ; Inoguchi, Toyoshi ; Takayanagi, Ryoichi ; Miyazaki, Ayako ; Koga, Masafumi. / A case of hemoglobin variant (Hb J-Lome) complicated by abnormally low HbAlc at the onset of fulminant type 1 diabetes mellitus. In: Journal of the Japan Diabetes Society. 2012 ; Vol. 55, No. 8. pp. 627-631.
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