A case of hepatitis C virus-associated liver cirrhosis with cryoglobulinemia, esophageal varices and ascites treated with pegylated interferon-α 2b and ribavirin

Shin Ya Onohara, Kazufumi Dohmen, Hirofumi Tanaka, Masatora Haruno, Makoto Irie, Shinji Shimoda

Research output: Contribution to journalArticle

Abstract

A 43-year-old Japanese man with hepatitis C virus-liver cirrhosis was referred to our hospital because of massive ascites. He had been treated with insulin injection for diabetes mellitus since 29-year-old. His data on admission showed total bilirubin of 0.3 mg/dl, AST 25 IU/l, ALT 23 IU/l, serum albumin 2.1 g/dl and creatinin 2.4 mg/dl, which were compatible with hypoalbuminemia and chronic renal failure. HCVRNA showed genotype 2A and a load of 5.1 logIU/ml. Liver cirrhosis with cryoglobulinemia was diagnosed. After endoscopic variceal ligation and paracentesis, peginterferon-α 2b/ribavirin therapy was initiated. Four weeks after, HCVRNA and serum cryoglobulinemia disappeared, while protein of 5.1 g/day in urine decreased to 2.6 g/day. At the end of 24-week therapy, HCVRNA and serum cryoglobulinemia were confirmed to be negative. PEGIFN/RBV therapy was effective for hepatitis C virus-associated liver cirrhosis with cryoglobulinemia.

Original languageEnglish
Pages (from-to)163-168
Number of pages6
JournalActa Hepatologica Japonica
Volume52
Issue number3
DOIs
Publication statusPublished - Apr 12 2011

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Cryoglobulinemia
Esophageal and Gastric Varices
Ribavirin
Ascites
Hepacivirus
Liver Cirrhosis
Interferons
Paracentesis
Hypoalbuminemia
Serum
Bilirubin
Serum Albumin
Chronic Kidney Failure
Ligation
Diabetes Mellitus
Therapeutics
Genotype
Urine
Insulin
Injections

All Science Journal Classification (ASJC) codes

  • Hepatology

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A case of hepatitis C virus-associated liver cirrhosis with cryoglobulinemia, esophageal varices and ascites treated with pegylated interferon-α 2b and ribavirin. / Onohara, Shin Ya; Dohmen, Kazufumi; Tanaka, Hirofumi; Haruno, Masatora; Irie, Makoto; Shimoda, Shinji.

In: Acta Hepatologica Japonica, Vol. 52, No. 3, 12.04.2011, p. 163-168.

Research output: Contribution to journalArticle

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