A case of hepatocellular carcinoma with right atrium tumor thrombus and multiple intrahepatic metastases that remarkably responded to combination therapy including surgery

Toru Otsuru, Shogo Kobayashi, Hidetoshi Eguchi, Hiroshi Wada, Yoshifumi Iwagami, Daisaku Yamada, Tadafumi Asaoka, Takehiro Noda, Kunihito Gotoh, Koji Umeshita, Yuichiro Doki, Masaki Mori

Research output: Contribution to journalReview article


The prognosis for hepatocellular carcinoma (HCC) with right atrium tumor thrombus (RATT) is dismal and necessary to be treated on as oncologic emergency. We report a case of HCC with RATT which was treated with multidisciplinary therapy including surgery. After repeated transarterial chemoembolization (TACE) and radiofrequency ablation (RFA),a 71-year-old man consulted to our hospital with multiple HCC, lung metastasis, and RATT. Left hemihepatectomy, thrombectomy of RATT, and 3 months of hepatic arterial infusion chemotherapy (HAIC) was performed, and intrahepatic HCCs were controlled. However, during treatment of lung metastasis by sorafenib, the patient died of brain metastasis, 3 years after the first treatment. Although surgery and HAIC may give a chance of further treatment by control of intrahepatic HCCs, stronger regimen for systemic HCC would be necessary.

Original languageEnglish
Pages (from-to)187-189
Number of pages3
JournalJapanese Journal of Cancer and Chemotherapy
Issue number1
Publication statusPublished - Jan 2018


All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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