A case of hereditary angioedema

Makoto Hanaguri, Kei Imazato, Shoko Mukumoto, Takahiko Horiuchi, Hideaki Suzuki

Research output: Contribution to journalArticle

Abstract

We reported a rare case of hereditary angioedema complicated by laryngeal edema. A 35-year-old man with history of repetitive paroxysmal facial edema complained of acute dyspnea. The patient manifested pronounced facial and laryngeal edema. He underwent urgent tracheostomy with corticosteroid administration, and the edema promptly subsided. A diagnosis of hereditary angioedmea was made from low levels of serum C4 and C1 inhibitor activity, and confirmed by the detection of a point mutation of the SERPING1 gene, which encodes CI inhibitor. He has been receiving prophylactic administration of tranexamic acid, and free from disease during a 24-month follow-up period. Etiology, clinical characteristics, diagnosis and treatment of hereditary angioedema were reviewed bibliographically.

Original languageEnglish
Pages (from-to)1109-1113
Number of pages5
JournalOtolaryngology - Head and Neck Surgery (Japan)
Volume86
Issue number13
Publication statusPublished - Dec 1 2014
Externally publishedYes

Fingerprint

Laryngeal Edema
Hereditary Angioedemas
Edema
Tranexamic Acid
Tracheostomy
Point Mutation
Dyspnea
Adrenal Cortex Hormones
Serum
Genes
Therapeutics

All Science Journal Classification (ASJC) codes

  • Surgery
  • Otorhinolaryngology

Cite this

Hanaguri, M., Imazato, K., Mukumoto, S., Horiuchi, T., & Suzuki, H. (2014). A case of hereditary angioedema. Otolaryngology - Head and Neck Surgery (Japan), 86(13), 1109-1113.

A case of hereditary angioedema. / Hanaguri, Makoto; Imazato, Kei; Mukumoto, Shoko; Horiuchi, Takahiko; Suzuki, Hideaki.

In: Otolaryngology - Head and Neck Surgery (Japan), Vol. 86, No. 13, 01.12.2014, p. 1109-1113.

Research output: Contribution to journalArticle

Hanaguri, M, Imazato, K, Mukumoto, S, Horiuchi, T & Suzuki, H 2014, 'A case of hereditary angioedema', Otolaryngology - Head and Neck Surgery (Japan), vol. 86, no. 13, pp. 1109-1113.
Hanaguri M, Imazato K, Mukumoto S, Horiuchi T, Suzuki H. A case of hereditary angioedema. Otolaryngology - Head and Neck Surgery (Japan). 2014 Dec 1;86(13):1109-1113.
Hanaguri, Makoto ; Imazato, Kei ; Mukumoto, Shoko ; Horiuchi, Takahiko ; Suzuki, Hideaki. / A case of hereditary angioedema. In: Otolaryngology - Head and Neck Surgery (Japan). 2014 ; Vol. 86, No. 13. pp. 1109-1113.
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