A case of IgG4-related disease diagnosed by a skin biopsy

Rieko Nakagawa, Futoshi Kouda, Akari Shigyou, Masutaka Furue

Research output: Contribution to journalArticle

Abstract

A 64-year-old man presented with a 3-year history of non-pruritic multiple brown papules on his face and trunk. Histopathological examination of a skin biopsy revealed a moderate dermal infiltration of lymphocytes and plasma cells around the vessels and adnexal structures with hyalinization. Immunostaining showed that a large proportion (>40%) of the infiltrating plasma cells were IgG4-positive. Laboratory investigations revealed raised levels of serum IgG and IgG4. A CT scan revealed a ground-glass pattern and lymphadenopathy in the lung, together with parotid swelling. Based on the clinical and histological findings, the skin disease was diagnosed as a cutaneous presentation of IgG4-related disease. After the systemic administration of 30 mg/day of prednisolone, a rapid response was obtained and the pulmonary symptoms and skin lesion were improved. However, tapering of prednisolone to 8 mg/day resulted in recurrence. IgG4-related disease is a newly recognized condition that affects multiple organs. Cutaneous features could be the first presentation of IgG4-related disease. Therefore, it is important for dermatologists to be aware of this disease.

Original languageEnglish
Pages (from-to)130-134
Number of pages5
JournalNishinihon Journal of Dermatology
Volume78
Issue number2
DOIs
Publication statusPublished - Jan 1 2016

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Immunoglobulin G
Biopsy
Skin
Prednisolone
Plasma Cells
Lung
Skin Diseases
Glass
Lymphocytes
Recurrence
Serum

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

A case of IgG4-related disease diagnosed by a skin biopsy. / Nakagawa, Rieko; Kouda, Futoshi; Shigyou, Akari; Furue, Masutaka.

In: Nishinihon Journal of Dermatology, Vol. 78, No. 2, 01.01.2016, p. 130-134.

Research output: Contribution to journalArticle

Nakagawa, Rieko ; Kouda, Futoshi ; Shigyou, Akari ; Furue, Masutaka. / A case of IgG4-related disease diagnosed by a skin biopsy. In: Nishinihon Journal of Dermatology. 2016 ; Vol. 78, No. 2. pp. 130-134.
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