Abstract
IgG4-related disease (Mikulicz disease) was first reported by Mikulicz in 1892 in a case of a man with bilateral swelling of the lachrymal, parotid, and submandibular glands. However, since Morgan and Castleman examined the pathological features of what they called Mikulicz disease in the 1950s, Mikulicz disease's been considered as a part of Sjogren's syndrome. In 2000, Tsubota et al. reported the difference in salivary gland destruction patterns between Mikulicz disease and Sjogren's syndrome, and explained the clinical differences of each disease. In 2004, Yamamoto et al. reported that the serum IgG4 level is extremely elevated in Mikulicz disease patients. The concept of a systemic IgG4-related syndrome came with the recognition of autoimmune pancreatitis, in which Hamano et al. reported in 2001 that the serum IgG4 level was elevated. Since that time, Mikulicz disease has been considered as a part of a systemic IgG4-related syndrome. We report herein on the case of a man who came to our institute in 2001 with bilateral swelling of the submandibular glands. We initially suspected malignant lymphoma and some other diseases, but during the long course of more investigations and follow-up, we finally diagnosed the condition as IgG4-related disease (Mikulicz disease).
| Original language | English |
|---|---|
| Pages (from-to) | 131-137 |
| Number of pages | 7 |
| Journal | Practica Otologica |
| Volume | 106 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2013 |
| Externally published | Yes |
Fingerprint
All Science Journal Classification (ASJC) codes
- Otorhinolaryngology
Cite this
A case of IgG4-related Disease (Mikulicz Disease) that Took long time to make a diagnosis. / Kubota, Marie; Chujo, Kyoko; Yasumatsu, Ryuji.
In: Practica Otologica, Vol. 106, No. 2, 02.2013, p. 131-137.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A case of IgG4-related Disease (Mikulicz Disease) that Took long time to make a diagnosis
AU - Kubota, Marie
AU - Chujo, Kyoko
AU - Yasumatsu, Ryuji
PY - 2013/2
Y1 - 2013/2
N2 - IgG4-related disease (Mikulicz disease) was first reported by Mikulicz in 1892 in a case of a man with bilateral swelling of the lachrymal, parotid, and submandibular glands. However, since Morgan and Castleman examined the pathological features of what they called Mikulicz disease in the 1950s, Mikulicz disease's been considered as a part of Sjogren's syndrome. In 2000, Tsubota et al. reported the difference in salivary gland destruction patterns between Mikulicz disease and Sjogren's syndrome, and explained the clinical differences of each disease. In 2004, Yamamoto et al. reported that the serum IgG4 level is extremely elevated in Mikulicz disease patients. The concept of a systemic IgG4-related syndrome came with the recognition of autoimmune pancreatitis, in which Hamano et al. reported in 2001 that the serum IgG4 level was elevated. Since that time, Mikulicz disease has been considered as a part of a systemic IgG4-related syndrome. We report herein on the case of a man who came to our institute in 2001 with bilateral swelling of the submandibular glands. We initially suspected malignant lymphoma and some other diseases, but during the long course of more investigations and follow-up, we finally diagnosed the condition as IgG4-related disease (Mikulicz disease).
AB - IgG4-related disease (Mikulicz disease) was first reported by Mikulicz in 1892 in a case of a man with bilateral swelling of the lachrymal, parotid, and submandibular glands. However, since Morgan and Castleman examined the pathological features of what they called Mikulicz disease in the 1950s, Mikulicz disease's been considered as a part of Sjogren's syndrome. In 2000, Tsubota et al. reported the difference in salivary gland destruction patterns between Mikulicz disease and Sjogren's syndrome, and explained the clinical differences of each disease. In 2004, Yamamoto et al. reported that the serum IgG4 level is extremely elevated in Mikulicz disease patients. The concept of a systemic IgG4-related syndrome came with the recognition of autoimmune pancreatitis, in which Hamano et al. reported in 2001 that the serum IgG4 level was elevated. Since that time, Mikulicz disease has been considered as a part of a systemic IgG4-related syndrome. We report herein on the case of a man who came to our institute in 2001 with bilateral swelling of the submandibular glands. We initially suspected malignant lymphoma and some other diseases, but during the long course of more investigations and follow-up, we finally diagnosed the condition as IgG4-related disease (Mikulicz disease).
UR - http://www.scopus.com/inward/record.url?scp=84874243723&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84874243723&partnerID=8YFLogxK
U2 - 10.5631/jibirin.106.131
DO - 10.5631/jibirin.106.131
M3 - Article
VL - 106
SP - 131
EP - 137
JO - Practica Otologica
JF - Practica Otologica
SN - 0032-6313
IS - 2
ER -