A case of IgG4-related sclerosing cholangitis associated with anti-GAD antibody-positive diabetes mellitus

Mika Fujihira, Taiki Higashi, Maiko Yokomizo, Keiichirou Takase, Yasuhiro Idewaki, Atsushi Fukunaga, Kunitoshi Sakurai, Hiroshi Toyoshima, Hiroshi Ohtani, Udai Nakamura, Takanari Kitazono, Masanori Iwase

Research output: Contribution to journalArticlepeer-review

Abstract

An 80-year-old woman was admitted due to liver dysfunction. She had been treated for type 2 diabetes mellitus by oral anti-diabetic medications. Laboratory examinations findings were as follows: AST 96 IU/L, ALT 134 IU/L, γ -GTP 823 IU/L, fasting serum glucose 204 mg/dL, HbA1c 8.3 %, C-peptide 2.46 ng/mL, anti-GAD antibody 55.8 U/mL, and IgG4 704 mg/dL. Imaging showed marked dilation of bile ducts without swelling of the pancreas or narrowing of the pancreatic ducts. The histological findings of a liver biopsy were compatible with IgG4-related sclerosing cholangitis. Both steroid therapy and insulin therapy were started and led to the amelioration of the liver function and insulin secretion as well as a reduction in anti-GAD antibody. We herein report a case of IgG4-related sclerosing cholangitis associated with diabetes mellitus with positivity for anti-GAD antibody, a situation that is rare to our knowledge.

Original languageEnglish
Pages (from-to)17-23
Number of pages7
JournalJournal of the Japan Diabetes Society
Volume62
Issue number1
DOIs
Publication statusPublished - 2019

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Fingerprint Dive into the research topics of 'A case of IgG4-related sclerosing cholangitis associated with anti-GAD antibody-positive diabetes mellitus'. Together they form a unique fingerprint.

Cite this