A case of imatinib-resistant GIST treated by sunitinib

Yasuo Sakamoto, Hisafumi Akimoto, Miyako Kojo, Hiroyuki Kawano, Yoshiki Chinen, Kazutoyo Morita, Masahiko Sugiyama, Hiroshi Saeki, Kazuhito Minami, Yuji Soejima, Yoshihisa Sakaguchi, Yasushi Toh, Takeshi Okamura

Research output: Contribution to journalArticlepeer-review

Abstract

We report a case of imatinib-resistant GIST, successfully treated by sunitinib. A 62-year-old man with high-grade fever and a huge abdominal tumor was diagnosed with malignant GIST and multiple liver metastases. We performed total gastrectomy combined with distal pancreatectomy, and splenectomy for palliation. Imatinib at a dose of 300 mg/day was administered postoperatively, and the liver metastases was well controlled. After nine months, abdominal dissemination increased, and we raised the dose of imatinib to 400 mg/day for the progressive state. Subsequently, we had to discontinue imatinib due to its adverse effects. Because the tumors progressed greatly while imatinib was discontinued, we changed to sunitinib. After wards, tumors reduced and his general condition improved remarkably. Although tumors progressed after five months, he was able to obtain good QOL during the administration of sunitinib. Sunitinib is useful for imatinib-resistant GIST, and may be a promising treatment even for patients with poor PS.

Original languageEnglish
Pages (from-to)827-830
Number of pages4
JournalJapanese Journal of Cancer and Chemotherapy
Volume38
Issue number5
Publication statusPublished - May 15 2011

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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