A case of insulin allergy: the crystalline human insulin may mask its antigenicity

Hiroshi Takatsuki, Hidehiro Ishii, Teruaki Yamauchi, Naoki Nakashima, Shouji Nagase, Akitaka Hisatomi, Fumio Umeda, Hajime Nawata

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

We report an unusual case of insulin allergy. A 48-year-old man with non-insulin-dependent diabetes mellitus receiving biosynthetic isophane human insulin (Humulin N) developed itchy wheal-and-flare reactions at the sites of injection. When Humulin N was changed to a semi-synthetic crystalline human insulin zine (Novolin U), the allergic reactions completely disappeared. Evaluation of his serum showed a high level of insulin-specific IgE. Skin testing with all commercially available insulins showed immediate local reactions to all agents tested except for Novolin U. In addition, decrystallized Novolin U prepared by lowering the pH with acetic acid also induced a positive reaction. These observations suggest that the crystallized structure of human insulin may mask its antigenicity for allergic reactions.

Original languageEnglish
Pages (from-to)137-139
Number of pages3
JournalDiabetes Research and Clinical Practice
Volume12
Issue number2
DOIs
Publication statusPublished - Jan 1 1991

Fingerprint

Masks
Hypersensitivity
Insulin
Insulins
Acetic Acid
Type 2 Diabetes Mellitus
Immunoglobulin E
Skin
Injections
Serum
Human Isophane Insulin

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

A case of insulin allergy : the crystalline human insulin may mask its antigenicity. / Takatsuki, Hiroshi; Ishii, Hidehiro; Yamauchi, Teruaki; Nakashima, Naoki; Nagase, Shouji; Hisatomi, Akitaka; Umeda, Fumio; Nawata, Hajime.

In: Diabetes Research and Clinical Practice, Vol. 12, No. 2, 01.01.1991, p. 137-139.

Research output: Contribution to journalArticle

Takatsuki, H, Ishii, H, Yamauchi, T, Nakashima, N, Nagase, S, Hisatomi, A, Umeda, F & Nawata, H 1991, 'A case of insulin allergy: the crystalline human insulin may mask its antigenicity', Diabetes Research and Clinical Practice, vol. 12, no. 2, pp. 137-139. https://doi.org/10.1016/0168-8227(91)90091-Q
Takatsuki, Hiroshi ; Ishii, Hidehiro ; Yamauchi, Teruaki ; Nakashima, Naoki ; Nagase, Shouji ; Hisatomi, Akitaka ; Umeda, Fumio ; Nawata, Hajime. / A case of insulin allergy : the crystalline human insulin may mask its antigenicity. In: Diabetes Research and Clinical Practice. 1991 ; Vol. 12, No. 2. pp. 137-139.
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